Journal of Cancer Research and Clinical Oncology

, Volume 132, Issue 2, pp 121–128

Effects of doxorubicin-containing chemotherapy and a combination with l-carnitine on oxidative metabolism in patients with non-Hodgkin lymphoma

  • Raimund Waldner
  • Claudia Laschan
  • Alfred Lohninger
  • Martin Gessner
  • Heinz Tüchler
  • Marlies Huemer
  • Wolfgang Spiegel
  • Heidrun Karlic
Original Paper

DOI: 10.1007/s00432-005-0054-8

Cite this article as:
Waldner, R., Laschan, C., Lohninger, A. et al. J Cancer Res Clin Oncol (2006) 132: 121. doi:10.1007/s00432-005-0054-8
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Abstract

Purpose: Chemotherapy regimens based on anthracycline (doxorubicin) are well established in lymphoma therapy. The purpose of this study was to examine the effects of l-carnitine with a view to reducing cytotoxic side-effects. Methods: 20 patients were scheduled to receive 3 g l-carnitine before each chemotherapy cycle, followed by 1 g l-carnitine/day during the following 21 days, while 20 patients received a placebo (randomized controlled trial). The plasma lipid profile and relative mRNA levels of key enzymes of oxidative metabolism (carnitine acyltransferases) were measured at three points of time. In addition to the clinical parameters we used the mRNA of white blood cells to evaluate the toxic effects on cardiomyocytes. Results: In the present study no cardiotoxicity of anthracycline therapy was detected. Carnitine treated patients showed a rise in plasma carnitine which led to an increase of relative mRNA levels from CPT1A (liver isoform of carnitine palmitoyltransferase) and OCTN2 (carnitine transporter). Following chemotherapy, an activation of carnitine acyltransferases was associated with a stimulation of OCTN2 in both groups. Conclusion: Biochemical and molecular analyses indicated a stimulation of oxidative metabolism in white blood cells through carnitine uptake.

Keywords

Anthracyclinel-CarnitineOxidative metabolism

Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • Raimund Waldner
    • 1
  • Claudia Laschan
    • 1
  • Alfred Lohninger
    • 3
  • Martin Gessner
    • 2
  • Heinz Tüchler
    • 6
  • Marlies Huemer
    • 4
  • Wolfgang Spiegel
    • 5
  • Heidrun Karlic
    • 6
  1. 1.3rd Department of MedicineHanusch HospitalViennaAustria
  2. 2.2nd Department of MedicineHanusch HospitalViennaAustria
  3. 3.Department of Medical ChemistryMedical University of Vienna ViennaAustria
  4. 4.Ludwig Boltzmann Institute for OsteologyHanusch HospitalViennaAustria
  5. 5.Department of General Practice, Center of Public HealthMedical University of ViennaViennaAustria
  6. 6.Ludwig Boltzmann Institute for Leukemia Research and HematologyHanusch HospitalViennaAustria