Abstract
Ureteropelvic junction obstruction (UPJO) and vesicoureteral reflux (VUR) are the most common uropathies. The co-occurrence of both anomalies has led to the practice of screening for VUR in children with UPJO to prevent deterioration of kidney function due to renal scarring following urinary tract infections (UTIs). We determined the prevalence of VUR in children with UPJO for a critical assessment of VUR screening by voiding cystourethrography (VCUG). A systematic search strategy in MEDLINE, EMBASE, and CENTRAL was carried out for all articles that included VCUG, and renal scintigraphy or any other appropriate imaging technique for the diagnosis of UPJO. Twenty studies were eligible for inclusion. We found a pooled prevalence for VUR of 8.2 % (95 % CI = 3.6–12.7), about a threefold increase compared to the general pediatric population. VUR occurred bilateral or contralateral to the kidney with UPJO in 5.7 % (95 % CI = 3.0–8.5), equivalent to 75 % of all children with VUR. Considering the effect size of VUR treatment with antibiotics, about 207 and 278 children would need to undergo VCUG to prevent one febrile UTI and one case of renal scarring by 1–2 years, respectively.
Conclusion: Against this background, screening for VUR needs to be scrutinized and restricted to selected risk groups.
What is known: • Screening of patients with ureteropelvic junction obstruction (UPJO) for vesicoureteral reflux (VUR) is recommended based on a small number of repeatedly cited studies. • The lack of conclusive evidence results in different treatment strategies and leads to difficulties when communicating diagnoses and treatment options to parents. |
What is new: • A robust prevalence for VUR in children with UPJO based on all published evidence and the resulting number needed to screen are given for decision-making in daily clinical practice. • The results may be a precursor for implementation into guidelines. |
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Abbreviations
- CI:
-
95 % confidence interval
- ESRD:
-
End-stage renal disease
- UPJO:
-
Ureteropelvic junction obstruction
- VUR:
-
Vesicoureteral reflux
- VCUG:
-
Voiding cystourethrography
References
Ahmed S, Savage JP (1985) Surgery of pelviureteric obstruction in the first year of life. Aust N Z J Surg 55(3):253–261
Ahmed S, Sparnon AL, Savage JP, Boucaut HA, Smith AJ (1986) Surgery of pelviureteric obstruction in 101 children over one year of age. Aust N Z J Surg 56(9):675–680
Aliabadi H, Ami Sidi A, Gonzalez R (1988) Management of ureteropelvic junction obstruction in infants and neonates. Eur Urol 15(1–2):103–107
Armada Maresca M, Rivilla Parra F, Vina Simon E, Garcia Casillas J (1997) Diagnosis and treatment of neonatal hydronephrosis. Influence of prenatal diagnosis. An Esp Pediatr 46(5):483–486
AWMF (2013) Leitlinie der Gesellschaft für Pädiatrische Radiologie (GPR). Harntransportstörung - Bildgebende Diagnostik. AWMF Register 064/006
Beetz R, Bokenkamp A, Brandis M, Hoyer P, John U, Kemper MJ, Kirschstein M, Kuwertz-Broking E, Misselwitz J, Muller-Wiefel DE, Rascher W (2001) Diagnosis of congenital dilatation of the urinary tract. Consensus Group of the Pediatric Nephrology Working Society in cooperation with the pediatric urology working Group of the German Society of urology and with the pediatric urology working Society in the Germany Society of pediatric surgery. Urologe A 40(6):495–507 quiz 508-499
Bejjani B, Belman AB (1982) Ureteropelvic junction obstruction in newborns and infants. J Urol 128(4):770–773
Belman AB (1995) A perspective on vesicoureteral reflux. Urol Clin North Am 22(1):139–150
Bernstein GT, Mandell J, Lebowitz RL, Bauer SB, Colodny AH, Retik AB (1988) Ureteropelvic junction obstruction in the neonate. J Urol 140(5 Pt 2):1216–1221
Blachar A, Blachar Y, Livne PM, Zurkowski L, Pelet D, Mogilner B (1994) Clinical outcome and follow-up of prenatal hydronephrosis. Pediatr Nephrol 8(1):30–35
Braga LH, Lorenzo AJ, Bagli DJ, Keays M, Farhat WA, Khoury AE, Salle JL (2008) Risk factors for recurrent ureteropelvic junction obstruction after open pyeloplasty in a large pediatric cohort. J Urol 180(4 Suppl):1684–1687 . doi:10.1016/j.juro.2008.03.086discussion 1687-1688
Core Team R (2014) R: a language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria https://www.R-project.org
Crabbe DC, Thomas DF, Gordon AC, Irving HC, Arthur RJ, Smith SE (1992) Use of 99mtechnetium-dimercaptosuccinic acid to study patterns of renal damage associated with prenatally detected vesicoureteral reflux. J Urol 148(4):1229–1231
Craig JC, Williams GJ (2011) Denominators do matter: it’s a myth--urinary tract infection does not cause chronic kidney disease. Pediatrics 128(5):984–985. doi:10.1542/peds.2011-2631
Craig JC, Irwig LM, Knight JF, Roy LP (2000) Does treatment of vesicoureteric reflux in childhood prevent end-stage renal disease attributable to reflux nephropathy? Pediatrics 105(6):1236–1241
Csaicsich D, Muller T, Arbeiter K, Balzar E, Thereska L, Aufricht C (2004) Management of congenital hydronephrosis with ureteropelvic junction obstruction: the Vienna-AKH experience 1986-2001. Wien Klin Wochenschr 116(21–22):725–729
Farhat W, McLorie G, Geary D, Capolicchio G, Bagli D, Merguerian P, Khoury A (2000) The natural history of neonatal vesicoureteral reflux associated with antenatal hydronephrosis. J Urol 164(3 Pt 2):1057–1060
Faust WC, Diaz M, Pohl HG (2009) Incidence of post-pyelonephritic renal scarring: a meta-analysis of the dimercapto-succinic acid literature. J Urol 181(1):290–297 . doi:10.1016/j.juro.2008.09.039discussion 297-298
Fazel R, Krumholz HM, Wang YF, Ross JS, Chen J, Ting HH, Shah ND, Nasir K, Einstein AJ, Nallamothu BK (2009) Exposure to low-dose ionizing radiation from medical imaging procedures. New Engl J Med 361(9):849–857. doi:10.1056/NEJMoa0901249
Furlow B (2011) Radiation protection in pediatric imaging. Radiol Technol 82(5):421–439
Harambat J, van Stralen KJ, Kim JJ, Tizard EJ (2012) Epidemiology of chronic kidney disease in children. Pediatr Nephrol 27(3):363–373. doi:10.1007/s00467-011-1939-1
Hegde S, Coulthard MG (2009) Renal agenesis and unilateral nephrectomy: what are the risks of living with a single kidney? Pediatr Nephrol 24(3):439–446. doi:10.1007/s00467-008-0924-9
Hellstrom A, Hanson E, Hansson S, Hjalmas K, Jodal U (1991) Association between urinary symptoms at 7 years old and previous urinary tract infection. Arch Dis Child 66(2):232–234
Higgins JPT, Thompson SG (2002) Quantifying heterogeneity in a meta-analysis. Stat Med 21(11):1539–1558. doi:10.1002/sim.1186
Higgins JP, Thompson SG, Deeks JJ, Altman DG (2003) Measuring inconsistency in meta-analyses. BMJ 327(7414):557–560. doi:10.1136/bmj.327.7414.557
Hoberman A, Charron M, Hickey RW, Baskin M, Kearney DH, Wald ER (2003) Imaging studies after a first febrile urinary tract infection in young children. N Engl J Med 348(3):195–202. doi:10.1056/NEJMoa021698
Hogdall C, Jorgensen BA, Hojensgard JC (1986) Hydronephrosis in childhood caused by ureteropelvic obstruction. Ugeskr Laeger 148(27):1676–1678
Hollowell JG, Altman HG, Snyder HM 3rd, Duckett JW (1989) Coexisting ureteropelvic junction obstruction and vesicoureteral reflux: diagnostic and therapeutic implications. J Urol 142(2 Pt 2):490–493 discussion 501
Hubertus J, Plieninger S, Martinovic V, Heinrich M, Schuster T, Burst M, Schroder A, Beetz R, Dietz HG, Stehr M (2013) Children and adolescents with ureteropelvic junction obstruction: is an additional voiding cystourethrogram necessary? Results of a multicenter study. World J Urol 31(3):683–687. doi:10.1007/s00345-012-0918-x
ICRP (2013) Radiological protection in paediatric diagnostic and interventional radiology. ICRP Publication 121. Ann ICRP 42 (2)
Ingraham SE, McHugh KM (2011) Current perspectives on congenital obstructive nephropathy. Pediatr Nephrol 26(9):1453–1461. doi:10.1007/s00467-011-1799-8
Karnak I, Woo LL, Shah SN, Sirajuddin A, Kay R, Ross JH (2008) Prenatally detected ureteropelvic junction obstruction: clinical features and associated urologic abnormalities. Pediatr Surg Int 24(4):395–402. doi:10.1007/s00383-008-2112-1
Kim YS, Do SH, Hong CH, Kim MJ, Choi SK, Han SW (2001) Does every patient with ureteropelvic junction obstruction need voiding cystourethrography? J Urol 165(6 Pt 2):2305–2307
Koff SAMK (ed) (2002) Anomalies of the kidney. Adult and pediatric urology, 4th edn. Philadelphia, Lippincott Williams and Wilkins
Lee YJ, Lee JH, Park YS (2012) Risk factors for renal scar formation in infants with first episode of acute pyelonephritis: a prospective clinical study. J Urol 187(3):1032–1036. doi:10.1016/j.juro.2011.10.164
Madden NP, Thomas DF, Gordon AC, Arthur RJ, Irving HC, Smith SE (1991) Antenatally detected pelviureteric junction obstruction. Is non-operation safe? Br J Urol 68(3):305–310
McIlroy PJ, Abbott GD, Anderson NG, Turner JG, Mogridge N, Wells JE (2000) Outcome of primary vesicoureteric reflux detected following fetal renal pelvic dilatation. J Paediatr Child Health 36(6):569–573
Nagler EV, Williams G, Hodson EM, Craig JC (2011) Interventions for primary vesicoureteric reflux. Cochrane Database Syst Rev 6:CD001532. doi:10.1002/14651858.CD001532.pub4
Nicolaou N, Renkema KY, Bongers EM, Giles RH, Knoers NV (2015) Genetic, environmental, and epigenetic factors involved in CAKUT. Nat Rev Nephrol 11(12):720–731. doi:10.1038/nrneph.2015.140
North American Pediatric Renal Trials and Collaborative Studies at http://web.emmes.com/study/ped/annlrept/annlrept.html (last accessed 10 August 2016).
O’Neil BB, Cartwright PC, Maves C, Hoeg K, Presson AP, Wallis MC (2014) Reliability of voiding cystourethrogram for the grading of vesicoureteral reflux. J Pediatr Urol 10(1):107–111. doi:10.1016/j.jpurol.2013.06.014
O’Reilly PH, Testa HJ, Lawson RS, Farrar DJ, Edwards EC (1978) Diuresis renography in equivocal urinary tract obstruction. Br J Urol 50(2):76–80
Oswald J (2012) Leitlinien Kinderurologie. J Urol Urogynaekol 19(1):40 Available: http://www.kup.at/kup/pdf/10440.pdf
Perisinakis K, Raissaki M, Damilakis J, Stratakis J, Neratzoulakis J, Gourtsoyiannis N (2006) Fluoroscopy-controlled voiding cystourethrography in infants and children: are the radiation risks trivial? Eur Radiol 16(4):846–851. doi:10.1007/s00330-005-0072-6
Perrelli L, Calisti A, Pintus C, D’Errico G (1985) Management of pelvi-ureteric junction obstruction in the first six months of life. Z Kinderchir 40(3):158–162. doi:10.1055/s-2008-1059736
Riedmiller H, Androulakakis P, Beurton D, Kocvara R, Gerharz E, European Association of U (2001) EAU guidelines on paediatric urology. Eur Urol 40(5):589–599
Rushton HG, Salem Y, Belman AB, Majd M (1994) Pediatric pyeloplasty: is routine retrograde pyelography necessary? J Urol 152(2 Pt 2):604–606
Schwarzer G (2015) meta: General Package for Meta-Analysis. http://CRAN.R-project.org/package=meta.
Shaikh N, Ewing AL, Bhatnagar S, Hoberman A (2010) Risk of renal scarring in children with a first urinary tract infection: a systematic review. Pediatrics 126(6):1084–1091. doi:10.1542/peds.2010-0685
Smellie JM, Normand IC, Katz G (1981) Children with urinary infection: a comparison of those with and those without vesicoureteric reflux. Kidney Int 20(6):717–722
Snodgrass WT, Shah A, Yang M, Kwon J, Villanueva C, Traylor J, Pritzker K, Nakonezny PA, Haley RW, Bush NC (2013) Prevalence and risk factors for renal scars in children with febrile UTI and/or VUR: a cross-sectional observational study of 565 consecutive patients. J Pediatr Urol 9(6 Pt A):856–863. doi:10.1016/j.jpurol.2012.11.019
Somogyi R, Oberritter Z, Juhasz Z, Vajda P, Pinter AB (2009) Combination of vesicoureteric reflux and vesicoureteric junction obstruction. Scand J Urol Nephrol 43(6):501–505. doi:10.3109/00365590903286671
Stratton KL, Pope JC, Adams MC, Brock JW 3rd, Thomas JC (2010) Implications of ionizing radiation in the pediatric urology patient. J Urol 183(6):2137–2142. doi:10.1016/j.juro.2010.02.2384
Tam JC, Hodson EM, Choong KK, Cass DT, Cohen RC, Gruenewald SM, Hayden LJ (1994) Postnatal diagnosis and outcome of urinary tract abnormalities detected by antenatal ultrasound. Med J Aust 160(10):633–637
Tekgül S, Dogan HS, Hoebeke P, Kocvara R, Nijman JM, Radmayr C, Stein R, Erdem E, Nambiar AK, Silay MS, Undre S (2016) Guidelines on paediatric urology, available at http://uroweb.org/guideline/paediatric-urology/. European Association of Urology
Toffolo A, Ammenti A, Montini G (2012) Long-term clinical consequences of urinary tract infections during childhood: a review. Acta Paediatr 101(10):1018–1031. doi:10.1111/j.1651-2227.2012.02785.x
Tsai JD, Huang FY, Tsai TC (1998) Asymptomatic vesicoureteral reflux detected by neonatal ultrasonographic screening. Pediatr Nephrol 12(3):206–209
Vihma Y, Parkkulainen KV (1983) Pelviureteric obstruction in children. Z Kinderchir 38(1):43–47. doi:10.1055/s-2008-1059939
Wennerstrom M, Hansson S, Jodal U, Sixt R, Stokland E (2000) Renal function 16 to 26 years after the first urinary tract infection in childhood. Arch Pediatr Adolesc Med 154(4):339–345
Wheeler D, Vimalachandra D, Hodson EM, Roy LP, Smith G, Craig JC (2003) Antibiotics and surgery for vesicoureteric reflux: a meta-analysis of randomised controlled trials. Arch Dis Child 88(8):688–694
Williams G, Fletcher JT, Alexander SI, Craig JC (2008) Vesicoureteral reflux. J Am Soc Nephrol 19(5):847–862. doi:10.1681/ASN.2007020245
Woo HH, Farnsworth RH (1996) Vesico-ureteric reflux and surgically treated pelvi-ureteric junction obstruction in infants under the age of 12 months. Aust N Z J Surg 66(12):824–825
Woodward M, Frank D (2002) Postnatal management of antenatal hydronephrosis. BJU Int 89(2):149–156
Yap HK, Lee BW, Joseph VT, Yeo CL (1984) Pelvi-ureteric junction obstruction in Singapore children--a retrospective study. Ann Acad Med Singap 13(4):590–592
Yeung CK, Godley ML, Dhillon HK, Gordon I, Duffy PG, Ransley PG (1997) The characteristics of primary vesico-ureteric reflux in male and female infants with pre-natal hydronephrosis. Brit J Urol 80(2):319–327. doi:10.1046/j.1464-410X.1997.00309.x
Acknowledgements
We would like to thank Gail Higgins, the Trials Search Co-ordinator of the Cochrane Renal Group and Christina Walter, the Search Co-ordinator at the University Hospital Tuebingen (Germany) for developing and running the search strategy used in this review.
Authors’ contributions
M. Weitz (MW) and M. Schmidt (MS) contributed equally to the manuscript. MW participated in design of the review, analysis, and interpretation of the data and writing of the review. MS participated in extraction and analysis of the data and writing of the review. Both authors have read and approved the final version of the manuscript.
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Weitz, M., Schmidt, M. To screen or not to screen for vesicoureteral reflux in children with ureteropelvic junction obstruction: a systematic review. Eur J Pediatr 176, 1–9 (2017). https://doi.org/10.1007/s00431-016-2818-3
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DOI: https://doi.org/10.1007/s00431-016-2818-3