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Perinatal and early postnatal reorganization of the subplate and related cellular compartments in the human cerebral wall as revealed by histological and MRI approaches

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Abstract

We analyzed the developmental history of the subplate and related cellular compartments of the prenatal and early postnatal human cerebrum by combining postmortem histological analysis with in vivo MRI. Histological analysis was performed on 21 postmortem brains (age range: 26 postconceptional weeks to 6.5 years) using Nissl staining, AChE-histochemistry, PAS–Alcian blue histochemistry, Gallyas’ silver impregnation, and immunocytochemistry for MAP2, synaptophysin, neurofilament, chondroitin sulfate, fibronectin, and myelin basic protein. The histological findings were correlated with in vivo MRI findings obtained in 30 age-matched fetuses, infants, and children. We analyzed developmental reorganization of major cellular (cell bodies, growing axons) and extracellular (extracellular matrix) components of the subplate and the developing cortex/white matter interface. We found that perinatal and postnatal reorganization of these tissue components is protracted (extending into the second year of life) and characterized by well-delineated, transient and previously undescribed structural and molecular changes at the cortex/white matter interface. The findings of this study are clinically relevant because they may inform and guide a proper interpretation of highly dynamic and hitherto puzzling changes of cortical thickness and cortical/white matter interface as described in current in vivo MRI studies.

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Acknowledgments

This work has been supported by Croatian Ministry of Science, Education and Sport Grants No. 108-1081870-1876 (to I.K.), No. 108-1081870-1878 (to M.J.), and Unity Through Knowledge Fund (UKF) grant (Director: I. Kostović). Authors gratefully acknowledge the technical assistance of Zdenka Cmuk, Danica Budinšćak, Božica Popović and Maja Horvat.

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Authors and Affiliations

  1. Croatian Institute for Brain Research, University of Zagreb School of Medicine, Šalata 12, 10000, Zagreb, Croatia

    Ivica Kostović, Nataša Jovanov-Milošević, Milan Radoš, Goran Sedmak, Lana Vasung, Marko Čuljat, Marko Radoš & Miloš Judaš

  2. Department of Paediatrics, Clinical Hospital Center Zagreb, University of Zagreb School of Medicine, Kišpatićeva 12, 10000, Zagreb, Croatia

    Vesna Benjak & Marko Čuljat

  3. Department of Health Psychology, University of Applied Health Sciences, 10000, Zagreb, Croatia

    Mirna Kostović-Srzentić

  4. Department of Clinical and Interventional Radiology, Clinical Hospital Center Zagreb, University of Zagreb School of Medicine, Kišpatićeva 12, 10000, Zagreb, Croatia

    Marko Radoš

  5. Division of Development and Growth, Department of Pediatrics, Geneva University Hospitals, Geneva, Switzerland

    Lana Vasung & Petra Hüppi

Authors
  1. Ivica Kostović
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  2. Nataša Jovanov-Milošević
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  3. Milan Radoš
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  4. Goran Sedmak
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  5. Vesna Benjak
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  6. Mirna Kostović-Srzentić
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  7. Lana Vasung
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  8. Marko Čuljat
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  9. Marko Radoš
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  10. Petra Hüppi
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  11. Miloš Judaš
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Corresponding authors

Correspondence to Ivica Kostović or Nataša Jovanov-Milošević.

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Kostović, I., Jovanov-Milošević, N., Radoš, M. et al. Perinatal and early postnatal reorganization of the subplate and related cellular compartments in the human cerebral wall as revealed by histological and MRI approaches. Brain Struct Funct 219, 231–253 (2014). https://doi.org/10.1007/s00429-012-0496-0

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  • DOI: https://doi.org/10.1007/s00429-012-0496-0

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