Skip to main content

Advertisement

SpringerLink
Log in

Infrequent mismatch repair protein loss in gallbladder cancer patients in Japan

  • Brief Report
  • Published:
Virchows Archiv Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

References

  1. Hundal R, Shaffer EA (2014) Gallbladder cancer: epidemiology and outcome. Clin Epidemiol 6:99–109. doi:10.2147/CLEP.S37357

    PubMed  PubMed Central  Google Scholar 

  2. Le DT, Uram JN, Wang H, Bartlett BR, Kemberling H, Eyring AD, Skora AD, Luber BS, Azad NS, Laheru D, Biedrzycki B, Donehower RC, Zaheer A, Fisher GA, Crocenzi TS, Lee JJ, Duffy SM, Goldberg RM, de la Chapelle A, Koshiji M, Bhaijee F, Huebner T, Hruban RH, Wood LD, Cuka N, Pardoll DM, Papadopoulos N, Kinzler KW, Zhou S, Cornish TC, Taube JM, Anders RA, Eshleman JR, Vogelstein B, Diaz LA Jr (2015) PD-1 blockade in tumors with mismatch-repair deficiency. N Engl J Med 372(26):2509–2520. doi:10.1056/NEJMoa1500596

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Dudley JC, Lin MT, Le DT, Eshleman JR (2016) Microsatellite instability as a biomarker for PD-1 blockade. Clin Cancer Res: Off J Am Assoc Cancer Res 22(4):813–820. doi:10.1158/1078-0432.CCR-15-1678

    Article  CAS  Google Scholar 

  4. Yoshida T, Sugai T, Habano W, Nakamura S, Uesugi N, Funato O, Saito K (2000) Microsatellite instability in gallbladder carcinoma: two independent genetic pathways of gallbladder carcinogenesis. J Gastroenterol 35(10):768–774

    Article  CAS  PubMed  Google Scholar 

  5. Kim YT, Kim J, Jang YH, Lee WJ, Ryu JK, Park YK, Kim SW, Kim WH, Yoon YB, Kim CY (2001) Genetic alterations in gallbladder adenoma, dysplasia and carcinoma. Cancer Lett 169(1):59–68

    Article  CAS  PubMed  Google Scholar 

  6. Nagai M, Watanabe M, Iwase T, Yamao K, Isaji S (2002) Clinical and genetic analysis of noncancerous and cancerous biliary epithelium in patients with pancreaticobiliary maljunction. World J Surg 26(1):91–98. doi:10.1007/s00268-001-0187-0

    Article  PubMed  Google Scholar 

  7. Rashid A, Ueki T, Gao YT, Houlihan PS, Wallace C, Wang BS, Shen MC, Deng J, Hsing AW (2002) K-ras mutation, p53 overexpression, and microsatellite instability in biliary tract cancers: a population-based study in China. Clin Cancer Res: Off J Am Assoc Cancer Res 8(10):3156–3163

    CAS  Google Scholar 

  8. Yanagisawa N, Mikami T, Yamashita K, Okayasu I (2003) Microsatellite instability in chronic cholecystitis is indicative of an early stage in gallbladder carcinogenesis. Am J Clin Pathol 120(3):413–417. doi:10.1309/BYRN-ALP8-GN63-DHAJ

    Article  CAS  PubMed  Google Scholar 

  9. Saetta AA, Papanastasiou P, Michalopoulos NV, Gigelou F, Korkolopoulou P, Bei T, Patsouris E (2004) Mutational analysis of BRAF in gallbladder carcinomas in association with K-ras and p53 mutations and microsatellite instability. Virchows Archiv : Int J Pathol 445(2):179–182. doi:10.1007/s00428-004-1046-9

    Article  CAS  Google Scholar 

  10. Roa JC, Roa I, Correa P, Vo Q, Araya JC, Villaseca M, Guzman P, Schneider BG (2005) Microsatellite instability in preneoplastic and neoplastic lesions of the gallbladder. J Gastroenterol 40(1):79–86. doi:10.1007/s00535-004-1497-4

    Article  CAS  PubMed  Google Scholar 

  11. Nagahashi M, Ajioka Y, Lang I, Szentirmay Z, Kasler M, Nakadaira H, Yokoyama N, Watanabe G, Nishikura K, Wakai T, Shirai Y, Hatakeyama K, Yamamoto M (2008) Genetic changes of p53, K-ras, and microsatellite instability in gallbladder carcinoma in high-incidence areas of Japan and Hungary. World J Gastroenterol 14(1):70–75

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Priya TP, Kapoor VK, Krishnani N, Agrawal V, Agrawal S (2010) Role of E-cadherin gene in gall bladder cancer and its precursor lesions. Virchows Archiv : Int J Pathol 456(5):507–514. doi:10.1007/s00428-010-0908-6

    Article  CAS  Google Scholar 

  13. Moy AP, Shahid M, Ferrone CR, Borger DR, Zhu AX, Ting D, Deshpande V (2015) Microsatellite instability in gallbladder carcinoma. Virchows Archiv : Int J Pathol 466(4):393–402. doi:10.1007/s00428-015-1720-0

    Article  CAS  Google Scholar 

  14. Hampel H, Frankel WL, Martin E, Arnold M, Khanduja K, Kuebler P, Clendenning M, Sotamaa K, Prior T, Westman JA, Panescu J, Fix D, Lockman J, LaJeunesse J, Comeras I, de la Chapelle A (2008) Feasibility of screening for Lynch syndrome among patients with colorectal cancer. J Clin Oncol: Off J Am Soc Clin Oncol 26(35):5783–5788. doi:10.1200/JCO.2008.17.5950

    Article  Google Scholar 

  15. Oguro S, Ino Y, Shimada K, Hatanaka Y, Matsuno Y, Esaki M, Nara S, Kishi Y, Kosuge T, Hiraoka N (2015) Clinical significance of tumor-infiltrating immune cells focusing on BTLA and Cbl-b in patients with gallbladder cancer. Cancer Sci 106(12):1750–1760. doi:10.1111/cas.12825

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Togo G, Toda N, Kanai F, Kato N, Shiratori Y, Kishi K, Imazeki F, Makuuchi M, Omata M (1996) A transforming growth factor beta type II receptor gene mutation common in sporadic cecum cancer with microsatellite instability. Cancer Res 56(24):5620–5623

    CAS  PubMed  Google Scholar 

  17. Chang HJ, Kim SW, Kim YT, Kim WH (1999) Loss of heterozygosity in dysplasia and carcinoma of the gallbladder. Mod Pathol: Off J U S Can Acad Pathol, Inc 12(8):763–769

    CAS  Google Scholar 

  18. Rashid A (2002) Cellular and molecular biology of biliary tract cancers. Surg Oncol Clin N Am 11(4):995–1009

    Article  PubMed  Google Scholar 

  19. Saetta AA, Gigelou F, Papanastasiou PI, Koilakou SV, Kalekou-Greca H, Miliaras D, Michalopoulos NV, Patsouris E (2006) High-level microsatellite instability is not involved in gallbladder carcinogenesis. Exp Mol Pathol 80(1):67–71. doi:10.1016/j.yexmp.2005.04.001

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgments

This study was supported by the National Cancer Center Research and Development Fund.

We thank Sachiko Miura, M.T. and Toshiko Sakaguchi, M. T. for the technical assistance.

Author information

Authors and Affiliations

  1. Division of Pathology and Clinical Laboratory, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan

    Hiroshi Yoshida & Nobuyoshi Hiraoka

  2. Hepatobiliary and Pancreatic Surgery Division, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan

    Kazuaki Shimada

Authors
  1. Hiroshi Yoshida
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Kazuaki Shimada
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Nobuyoshi Hiraoka
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Nobuyoshi Hiraoka.

Ethics declarations

All study participants provided informed consent, and the study was conducted in accordance with the Declaration of Helsinki and with approval of the Institutional Review Board of the National Cancer Center, Tokyo, Japan.

Conflict of interest

The authors declare that they have no conflict of interest.

Electronic supplementary material

Supplementary table 1.

Patient characteristics (DOCX 14 kb)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Yoshida, H., Shimada, K. & Hiraoka, N. Infrequent mismatch repair protein loss in gallbladder cancer patients in Japan. Virchows Arch 470, 109–112 (2017). https://doi.org/10.1007/s00428-016-2043-5

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00428-016-2043-5

Keywords

Search

Navigation