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Low-grade fibromyxoid sarcoma mimicking solitary fibrous tumor: a report of two cases

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Abstract

Low-grade fibromyxoid sarcoma (LGFMS) is an uncommon fibroblastic neoplasm with many morphologic mimics. Solitary fibrous tumor is a more common fibroblastic neoplasm, but the two rarely enter the same differential diagnosis. However, here, we report two unusual cases of LGFMS, containing dilated, hemangiopericytoma-like blood vessels, which prompted diagnostic considerations of solitary fibrous tumor. Both cases presented were confirmed to harbor FUS gene rearrangement, thereby confirming a diagnosis of LGFMS. One case is that of an 18-year-old male with a left forearm mass, and the other a 50-year-old man with a left popliteal mass. While both cases show some histologic features of LGFMS, the non-classical, dilated blood vessel pattern seen here may serve as a diagnostic pitfall, as LGFMS normally exhibits fine, curvilinear blood vessels. To our knowledge, there is only one other report of LGFMS displaying such hemangiopericytoma-like blood vessels. In summary, when encountering a bland spindle cell neoplasm with classic hemangiopericytoma-like blood vessels, it is prudent to consider a diagnosis of LGFMS besides solitary fibrous tumor—particularly in the absence of CD34 immunoreactivity as it may be a rare, mimicking variant of LGFMS.

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We declare that we have no conflict of interest.

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Authors and Affiliations

  1. Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada

    Sylvia Papp

  2. Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, ON, Canada

    Brendan C. Dickson

  3. Laboratory Medicine Program, University Health Network – Toronto General Hospital, Toronto, ON, Canada

    Runjan Chetty

  4. Department of Pathology, University Health Network – Toronto General Hospital, 200 Elizabeth Street, 11th Floor, Room 449, Toronto, ON, M5G 2C4, Canada

    Runjan Chetty

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  1. Sylvia Papp
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  2. Brendan C. Dickson
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Correspondence to Runjan Chetty.

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Papp, S., Dickson, B.C. & Chetty, R. Low-grade fibromyxoid sarcoma mimicking solitary fibrous tumor: a report of two cases. Virchows Arch 466, 223–228 (2015). https://doi.org/10.1007/s00428-014-1684-5

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  • DOI: https://doi.org/10.1007/s00428-014-1684-5

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