Virchows Archiv

, Volume 464, Issue 2, pp 197–202

Expression of angiogenic factors is increased in metastasised renal cell carcinomas

  • Mahmoud Abbas
  • Johannes Salem
  • Angelika Stucki-Koch
  • Mareike Rickmann
  • Viktor Grünwald
  • Thomas Herrmann
  • Danny Jonigk
  • Hans Kreipe
  • Kais Hussein
Original Article

DOI: 10.1007/s00428-013-1529-7

Cite this article as:
Abbas, M., Salem, J., Stucki-Koch, A. et al. Virchows Arch (2014) 464: 197. doi:10.1007/s00428-013-1529-7

Abstract

Clear cell renal cell carcinomas (ccRCC) have aberrant signalling pathways which affect vascular endothelial growth factor and are related to increased tumour angiogenesis. Little is known about other angiogenesis-associated genes in primary tumours and metastases. Quantitative PCR of 45 angiogenesis-associated gene transcripts was performed on formalin-fixed and paraffin-embedded tissues from primary ccRCC (n = 18) and their metastases (n = 17; in 8/17 cases the corresponding primary tumour could be analysed). In metastases, a significant increase was found in the expression of 15 pro-angiogenic (such as prostaglandin-endoperoxide synthase 1) and also anti-angiogenic (such as TIMP metallopeptidase inhibitor 2) factors. Comparison of a primary with its metastasis performed on eight cases showed that even without preceding anti-angiogenic therapy in metastases expression of angiogenic factors is increased. In ccRCC, the effects of anti-angiogenic factors are superimposed by pro-angiogenic factors. Increased expression of angiogenic factors in metastases might be related to development of resistance after anti-angiogenic therapy but might also be an inherent biological characteristic.

Keywords

Pathology Kidney disease Molecular biology Cancer 

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Mahmoud Abbas
    • 1
  • Johannes Salem
    • 1
  • Angelika Stucki-Koch
    • 1
  • Mareike Rickmann
    • 2
  • Viktor Grünwald
    • 2
  • Thomas Herrmann
    • 3
  • Danny Jonigk
    • 1
  • Hans Kreipe
    • 1
  • Kais Hussein
    • 1
  1. 1.Institut für PathologieMedizinische Hochschule HannoverHannoverGermany
  2. 2.Klinik für Hämatologie, Hämostaseologie, Onkologie und StammzelltransplantationMedizinische Hochschule HannoverHannoverGermany
  3. 3.Klinik für Urologie und Urologische OnkologieMedizinische Hochschule HannoverHannoverGermany