Abstract
Tight junctions are critically important for many physiological functions, including the maintenance of cell polarity, regulation of paracellular permeability, and involvement in signal transduction pathways to regulate integral cellular processes. Furthermore, tight junctions enable epithelial cells to form physical barriers, which act as an innate immune mechanism that can impede viral infection. Viruses, in turn, have evolved mechanisms to exploit tight junction proteins to gain access to cells or spread through tissues in an infected host. Claudin family proteins are integral components of tight junctions and are thought to play crucial roles in regulating their permeability. Claudins have been implicated in the infection process of several medically important human pathogens, including hepatitis C virus, dengue virus, West Nile virus, and human immunodeficiency virus, among others. In this review, we summarize the role of claudins in viral infections and discuss their potential as novel antiviral targets. A better understanding of claudins during viral infection may provide insight into physiological roles of claudins and uncover novel therapeutic antiviral strategies.
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Acknowledgements
TFB acknowledges support through funding from the European Union (ERC-2014-AdG-HEPCIR, FP7 HepaMAb, H2020 HEPCAR, and Interreg IV FEDER-Hepato-Regio-Net 2012), the US National Institutes of Health (1 U19 AI23862 01), the Agence Nationale de Recherches sur le SIDA (ANRS), the Direction Générale de l’Offre de Soins (A12027MS), Inserm, and the University of Strasbourg Foundation. This work has been published under the framework of the LABEX ANR-10-LABX-0028_HEPSYS and benefits from funding from the state managed by the French National Research Agency as part of the investments for the future program. CCC is supported by fellowships from the Canadian Institutes of Health Research (201411MFE- 338606-245517) and the Canadian Network on Hepatitis C.
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The authors declare no conflict of interest. Thomas F. Baumert is a co-inventor on patent applications for claudin-1-targeting antibodies for prevention and treatment of HCV infection and liver disease.
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This article is published as part of the Special Issue on Physiology, Pathophysiology, and Clinical Impact of Claudins
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Colpitts, C.C., Baumert, T.F. Claudins in viral infection: from entry to spread. Pflugers Arch - Eur J Physiol 469, 27–34 (2017). https://doi.org/10.1007/s00424-016-1908-4
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DOI: https://doi.org/10.1007/s00424-016-1908-4