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The sodium/calcium exchanger family—SLC8

  • The ABC of Solute Carriers
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Abstract

The Na+/Ca2+ exchanger gene family encompasses three distinct proteins, NCX1, NCX2, and NCX3, which mediate cellular Ca2+ efflux and thus contribute to intracellular Ca2+ homeostasis. NCX1 is expressed ubiquitously while NCX2 and NCX3 are limited to brain and skeletal muscle. NCX1 exchanges 3 extracellular Na+ for 1 intracellular Ca2+. In addition to transporting Na+ and Ca2+, NCX1 activity is also regulated by these cations. NCX1 is especially important in regulating cardiac contractility.

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  1. Department of Physiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095-1760, USA

    Beate D. Quednau, Debora A. Nicoll & Kenneth D. Philipson

  2. Cardiovascular Research Laboratories, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095-1760, USA

    Beate D. Quednau, Debora A. Nicoll & Kenneth D. Philipson

  3. Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095-1760, USA

    Kenneth D. Philipson

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  1. Beate D. Quednau
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Quednau, B.D., Nicoll, D.A. & Philipson, K.D. The sodium/calcium exchanger family—SLC8. Pflugers Arch - Eur J Physiol 447, 543–548 (2004). https://doi.org/10.1007/s00424-003-1065-4

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