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Variability in pulmonary function following rapid altitude ascent to the Amundsen–Scott South Pole station

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Abstract

The impact of acute altitude exposure on pulmonary function is variable. A large inter-individual variability in the changes in forced expiratory flows (FEFs) is reported with acute exposure to altitude, which is suggested to represent an interaction between several factors influencing bronchial tone such as changes in gas density, catecholamine stimulation, and mild interstitial edema. This study examined the association between FEF variability, acute mountain sickness (AMS) and various blood markers affecting bronchial tone (endothelin-1, vascular endothelial growth factor (VEGF), catecholamines, angiotensin II) in 102 individuals rapidly transported to the South Pole (2835 m). The mean FEF between 25 and 75% (FEF25–75) and blood markers were recorded at sea level and after the second night at altitude. AMS was assessed using Lake Louise questionnaires. FEF25–75 increased by an average of 12% with changes ranging from −26 to +59% from sea level to altitude. On the second day, AMS incidence was 36% and was higher in individuals with increases in FEF25–75 (41 vs. 22%, P = 0.05). Ascent to altitude induced an increase in endothelin-1 levels, with greater levels observed in individuals with decreased FEF25–75. Epinephrine levels increased with ascent to altitude and the response was six times larger in individuals with decreased FEF25–75. Greater levels of endothelin-1 in individuals with decreased FEF25–75 suggest a response consistent with pulmonary hypertension and/or mild interstitial edema, while epinephrine may be upregulated in these individuals to clear lung fluid through stimulation of β2-adrenergic receptors.

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Acknowledgments

This study was supported by a grant from the National Science Foundation (B-179-M). We would like to thank the medical staff at McMurdo and Amundsen–Scott South Pole stations for their help as well as the personnel who volunteered for the study.

Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Human Integrative and Environmental Physiology Laboratory, Division of Cardiovascular Diseases, Mayo Clinic, Joseph 4-221, 200 First Street SW, Rochester, MN, 55905, USA

    S. Lalande, P. J. Anderson, A. D. Miller, M. L. Ceridon, K. C. Beck, K. A. O’Malley, J. B. Johnson & B. D. Johnson

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  1. S. Lalande
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  2. P. J. Anderson
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  3. A. D. Miller
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  4. M. L. Ceridon
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  5. K. C. Beck
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  6. K. A. O’Malley
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  7. J. B. Johnson
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  8. B. D. Johnson
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Correspondence to S. Lalande.

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Communicated by Susan A. Ward.

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Lalande, S., Anderson, P.J., Miller, A.D. et al. Variability in pulmonary function following rapid altitude ascent to the Amundsen–Scott South Pole station. Eur J Appl Physiol 111, 2221–2228 (2011). https://doi.org/10.1007/s00421-011-1864-9

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  • DOI: https://doi.org/10.1007/s00421-011-1864-9

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