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Contact allergy to preservatives in patients with occupational contact dermatitis and exposure analysis of preservatives in registered chemical products for occupational use

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Abstract

Purpose

The aim of the study is to investigate risk factors for sensitization to preservatives and to examine to which extent different preservatives are registered in chemical products for occupational use in Denmark.

Methods

A retrospective epidemiological observational analysis of data from a university hospital was conducted. All patients had occupational contact dermatitis and were consecutively patch tested with 11 preservatives from the European baseline series and extended patch test series during a 5-year period: 2009–2013. Information regarding the same preservatives in chemical products for occupational use (‘substances and materials’) registered in the Danish Product Register Database (PROBAS) was obtained.

Results

The frequency of preservative contact allergy was 14.2% (n = 141) in 995 patients with occupational contact dermatitis. Patients with preservative contact allergy had significantly more frequently facial dermatitis (19.9 versus 13.1%) and age > 40 years (71.6 versus 45.8%) than patients without preservative contact allergy, whereas atopic dermatitis was less frequently observed (12.1 versus 19.8%). Preservative contact allergy was more frequent in painters with occupational contact dermatitis as compared to non-painters with occupational contact dermatitis (p < 0.001). This was mainly caused by contact allergy to methylisothiazolinone and contact allergy to formaldehyde. Analysis of the registered substances and materials in PROBAS revealed that preservatives occurred in several product categories, e.g., ‘paints and varnishes’, ‘cleaning agents’, ‘cooling agents’, and ‘polishing agents’. Formaldehyde and isothiazolinones were extensively registered in PROBAS.

Conclusions

The extensive use of formaldehyde and isothiazolinones in chemical products for occupational use may be problematic for the worker. Appropriate legislation, substitution, and employee education should be prioritized.

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References

  • Aalto-Korte K, Kuuliala O, Suuronen K, Alanko K (2008) Occupational contact allergy to formaldehyde and formaldehyde releasers. Contact Dermat 59:280–289. doi:10.1111/j.1600-0536.2008.01422.x

    Article  CAS  Google Scholar 

  • Aerts O, Baeck M, Constandt L, Dezfoulian B, Jacobs MC, Kerre S, Lapeere H, Pierret L, Wouters K, Goossens A (2014) The dramatic increase in the rate of methylisothiazolinone contact allergy in Belgium: a multicentre study. Contact Dermat 71:41–48. doi:10.1111/cod.12249

    Article  CAS  Google Scholar 

  • Bauer A, Geier J, Mahler V, Uter W. [Contact allergies in the German workforce: Data of the IVDL network 2003–2013] (2015). Hautarzt;66:652–664

  • Danish Working Environment Authority (2016) Product Registry:’Substances and materials that must be notified to the Product Registry’. http://engelsk.arbejdstilsynet.dk/en/produktregistret/substances-and-materials-that-must-be-notified. Accessed 22 April 2016.

  • de Groot A, Herxheimer A. Isothiazolinone preservative: cause of a continuining epidemic of cosmetic dermatitis (1989). Lancet 1:314–316

    Article  Google Scholar 

  • European Chemicals Agency (ECHA) 2016a). Guidance on labelling and packaging in accordance with regulation (EC) No. 1272/2008. Reference ECHA-11-G-04-EN. https://echa.europa.eu/documents/10162/13562/clp_labelling_en.pdf. Accessed 4 May 2016.

  • European Chemicals Agency (ECHA) (2016b) C&L inventory database. http://echa.europa.eu/information-on-chemicals/cl-inventory-database. Accessed 22 April 2016.

  • Flyvholm MA (2005) Preservatives in registered chemical products. Contact Dermat 53:27–32. doi:10.1111/j.01051873.2005.00629.x

    Article  CAS  Google Scholar 

  • Flyvholm MA, Andersen P (1993) Identification of formaldehyde releasers and occurrence of formaldehyde and formaldehyde releasers in registered chemical products. Am J Ind Med 24:533–552

    Article  CAS  Google Scholar 

  • Friis UF, Menné T, Flyvholm MA, Bonde JP, Johansen JD (2013a) Occupational allergic contact dermatitis diagnosed by a systematic stepwise exposure assessment of allergens in the work environment. Contact Dermat 69:153–163. doi:10.1111/cod.12102

    Article  CAS  Google Scholar 

  • Friis UF, Menné T, Flyvholm MA, Bonde JP, Johansen JD (2013b) Occupational allergic contact dermatitis diagnosed by a systematic stepwise exposure assessment of allergens in the work environment. Contact Dermat 69:153–163

    Article  CAS  Google Scholar 

  • Friis UF, Menné T, Flyvholm MA, Bonde JP, Lepoittevin JP, Le Coz CJ, Johansen JD (2014a) Isothiazolinones in commercial products at Danish workplaces. Contact Dermat 71:65–74. doi:10.1111/cod.12235

    Article  CAS  Google Scholar 

  • Friis UF, Dahlin J, Bruze M, Menné T, Johansen JD (2014b) Hidden exposure to formaldehyde in a swab caused allergic contact dermatitis. Contact Dermat 70:258–260. doi:10.1111/cod.12172

    Article  Google Scholar 

  • Gonçalo M, Goossens A. (2013) While Rome burns: the epidemic of contact allergy to methylisothiazolinone. Contact Dermatiits 68:257–258 doi:10.1111/cod.12098.

    Article  Google Scholar 

  • Johansen JD, Aalto-Korte K, Agner T, Andersen KE, Bircher A, Bruze M, Cannavó A, Giménez-Arnau A, Gonçalo M, Goossens A, John SM, Lidén C, Lindberg M, Mahler V, Matura M, Rustemeyer T, Serup J, Spiewak R, Thyssen JP, Vigan M, White IR, Wilkinson M, Uter W (2015) European society of contact Dermatitis guideline for diagnostic patch testing—recommendations on best practice. Contact Dermat 73:195–221. doi:10.1111/cod.12432.

    Article  Google Scholar 

  • Lundov MD, Kolarik B, Bossi R, Gunnarsen L, Johansen JD (2014) Emission of isothiazolinones from water-based paints. Environ Sci Technol. 2014 Jun 17;48(12):6989–6994 doi:10.1021/es500236m.

    Article  CAS  Google Scholar 

  • Mose AP, Lundov MD, Zachariae C, Menné T, Veien NK, Laurberg G, Kaaber K, Avnstorp C, Andernsen KE, Paulsen E, Mørtz CG, Sommerlund M, DaNielsen A, Thormann J, Kristensen O, Kristensen B, Andersen BL, Vissing S, Nielsen NH, Johansen JD (2012) Occupational contact dermatitis in painters: an analysis of patch test data from the Danish Contact Dermatitis Group. Contact Dermat 67:293–297. doi:10.1111/j.1600-0536.2012.02074.x

    Article  CAS  Google Scholar 

  • Schnuch A, Lessmann H, Geier J, Uter W (2011) Contact allergy to preservatives. Analysis of IVDK data 1996–2009. Br J Dermatol 164:1316–1325. doi:10.1111/j.1365-2133.2011.10253.x

    Article  CAS  Google Scholar 

  • Schwensen JF, Friis UF, Menne T, Johansen JD (2013) One thousand cases of severe occupational contact dermatitis. Contact Dermat 68:259–268. doi:10.1111/cod.12045

    Article  Google Scholar 

  • Schwensen JF, Menne T, Andersen KE, Sommerlund M, Johansen JD (2014a) Occupations at risk of developing contact allergy to isothiazolinones in Danish contact dermatitis patients: results from a Danish multicentre study (2009–2012). Contact Dermat 71:295–302. doi:10.1111/cod.12286

    Article  Google Scholar 

  • Schwensen JF et al (2014b) Occupational contact dermatitis in blue-collar workers: results from a multicentre study from the Danish Contact Dermatitis Group (2003–2012). Contact Dermat 71:348–355. doi:10.1111/cod.12277

    Article  CAS  Google Scholar 

  • Schwensen JF, White IR, Thyssen JP, Menné T, Johansen JD (2015b) Failures in risk assessment and risk management for cosmetic preservatives in Europe and the impact on public health. Contact Dermat 133:41. doi:10.1111/cod.12446

    Google Scholar 

  • Schwensen JF, Lundov MD, Bossi R, Banerjee P, Giménez-Arnau E, Lepoittevin JP, Lidén C, Uter W, Yazar K, White IR, Johansen JD (2015b) Contact Dermat 72:127–138. doi:10.1111/cod.12322

    Article  CAS  Google Scholar 

  • Swedman C, Andersen KE, Brandão FM, Bruynzeel DP, Diepgen TL, Frosch PJ, Rustemeyer T, Giménez-Arnau A, Gonçalo M, Goossens A, Johansen JD, Lahti A, Menné T, Seidenari S, Tosti A, Wahlberg JE, White IR, Wilkinson JD, Mowitz M, Bruze M (2012) Follow-up of the monitored levels of preservative sensitivity in Europe: a overview of the years 2001–2008. Contact Dermat 67:312–314. doi:10.1111/j.1600-0536.2012.02140.x

    Article  Google Scholar 

  • Thorud S, Gjolstad M, Ellingsen DG, Molander P (2005) Air formaldehyde and solvent concentrations during surface coating with acid-curing lacquers and paints in the woodworking and furniture industry. J Environ Menit 6:586–591

    Article  Google Scholar 

  • Thyssen JP, Engkilde K, Lundov MD, Carlsen BC, Menné T, Johansen JD (2010) Temporal trends of preservative allergy in Denmark (1985–2008). Contact Dermat 62:102–108. doi:10.1111/j.1600-0536.2009.01668.x

    Article  Google Scholar 

  • Uter W, Geier J, Bauer A, Schnuch A (2013) Risk factors associated with methylisothiazolinone contact sensitization. Contact Dermatitis 69:231–238. doi:10.1111/cod.12123

    Article  CAS  Google Scholar 

  • Vauhkala A-R, Pesonen M, Suomela S, Kuuliala O, Suuronen K, Aalto-Korte K (2015) Occupational contact allergy to methylchloroisothiazolinone/methylisothiazolinone and methylisothiazolinone. Contact Dermat 73:150–156. doi:10.1111/cod.12413

    Article  CAS  Google Scholar 

  • Wilkinson JD, Shaw S, Andersen KE, Brandao FM, Bruynzeel DP, Bruze M, Camarasa JM, Diepgen TL, Ducombs G, Frosch PJ, Goossens A, Lachappelle JM, Lahti A, Menné T, Seidenari S, Tosti A, Wahlberg JE (2002) Monitoring levels of preservative sensitivity in Europe. A 10-year overview (1991–2000). Contact Dermat 46(4):207–210

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Dermato-Allergology, National Allergy Research Centre, Copenhagen University Hospital Gentofte, Kildegårdsvej 28, 2900, Hellerup, Denmark

    Jakob Ferløv Schwensen, Ulrik Fischer Friis, Torkil Menné & Jeanne Duus Johansen

  2. National Research Centre for the Working Environment, Lersø Parkallé 105, 2100, Copenhagen, Denmark

    Mari-Ann Flyvholm

Authors
  1. Jakob Ferløv Schwensen
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  2. Ulrik Fischer Friis
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  3. Torkil Menné
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  4. Mari-Ann Flyvholm
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  5. Jeanne Duus Johansen
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Correspondence to Jakob Ferløv Schwensen.

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Schwensen, J.F., Friis, U.F., Menné, T. et al. Contact allergy to preservatives in patients with occupational contact dermatitis and exposure analysis of preservatives in registered chemical products for occupational use. Int Arch Occup Environ Health 90, 319–333 (2017). https://doi.org/10.1007/s00420-017-1203-5

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  • DOI: https://doi.org/10.1007/s00420-017-1203-5

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