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Genetic variation in APE1 gene promoter is associated with noise-induced hearing loss in a Chinese population

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Abstract

Objective

To investigate whether the apurinic/apyrimidinic endonuclease 1 (APE1) 1349 T>G and -656 T>G polymorphisms were associated with the risk of noise-induced hearing loss (NIHL) in a Chinese population.

Methods

The two APE1 polymorphisms were analyzed among 613 NIHL workers and 613 normal hearing workers using the minor groove binder TaqMan probe assay.

Results

We found that the APE1 -656 TT genotype was associated with a increased risk of NIHL [adjusted odds ratio (OR) 1.46, 95 % confidence interval (CI) 1.05–2.06]. This increased risk was more pronounced in the stratification analysis. Furthermore, we found that subjects with two risk genotypes (hOGG1 Cys/Cys, APE1 -656 TT) had a significantly increased risk of NIHL (adjusted OR 1.91, 95 % CI 1.27–2.88).

Conclusion

Our study identified that the APE1 -656 T>G polymorphism may contribute to the susceptibility of NIHL.

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Acknowledgments

This study was mainly supported by Jiangsu Province’s Outstanding Medical Academic Leader program (LJ201130) and Projects of Jiangsu Society Development (BS2005661), and was partly supported by the Kunshan Municipal Society Development (KS1354).

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    Authors and Affiliations

    1. Kunshan Municipal Center for Disease Prevention and Control, Kunshan, China

      Huanxi Shen, Jian Shi, Cheng Du & Zhimin Tong

    2. Department of Environmental Genomics, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Nanjing Medical University, Nanjing, China

      Huanxi Shen, Lei Han & Baoli Zhu

    3. Yangzhou Center for Disease Prevention and Control, Yangzhou, China

      Jianrui Dou

    4. Institute of Occupational Disease Prevention, Jiangsu Provincial Center for Disease Prevention and Control, 172 Jiangsu Road, Nanjing, 210009, China

      Lei Han, Ying Bai, Zhiqiang Hong, Hengdong Zhang, Feng Zhang & Baoli Zhu

    5. The First People’s Hospital of Kunshan, Kunshan, China

      Qian Li

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    1. Huanxi Shen
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    Correspondence to Baoli Zhu.

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    Huanxi Shen, Jianrui Dou, and Lei Han have contributed equally to this work.

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    Shen, H., Dou, J., Han, L. et al. Genetic variation in APE1 gene promoter is associated with noise-induced hearing loss in a Chinese population. Int Arch Occup Environ Health 89, 621–628 (2016). https://doi.org/10.1007/s00420-015-1100-8

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    • DOI: https://doi.org/10.1007/s00420-015-1100-8

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