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Clinical outcomes and antibiotic susceptibilities of Staphylococcus aureus endophthalmitis

  • Retinal Disorders
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Abstract

Purpose

To compare the antibiotic susceptibilities and visual acuity (VA) outcomes in endophthalmitis caused by methicillin-resistant (MRSA) versus methicillin-sensitive S. aureus (MSSA).

Methods

The records of 34 cases of S. aureus endophthalmitis at The New York Eye and Ear Infirmary from Jan 1997 to June 2011 were reviewed. Antibiotic susceptibility profiles over time and VA at presentation and at 3, 6, and ≥12 months were recorded. S. aureus isolates were grouped based on oxacillin resistance.

Results

Of the 34 cases, 15 (44 %) were MRSA and 19 (56 %) MSSA. Median presenting VA was hand motions (logMAR 4.0) in both the MRSA and MSSA groups. There was no statistically significant difference in VA between the MRSA and MSSA groups at 3, 6, or ≥12 months. No MRSA isolates were resistant to vancomycin or gentamicin. While over 85 % of MRSA isolates tested for fourth-generation fluoroquinolones were resistant, just 10 % MSSA isolates tested were resistant. There was a trend suggesting an increase in the proportion of MRSA isolates compared to MSSA isolates over the course of the study period.

Conclusions

There was no statistical difference in short- or long-term VA outcomes between the MRSA and MSSA groups at any time point. Resistance to fourth-generation fluoroquinolones was present in over 85 % of MRSA isolates, but just 10 % of MSSA isolates. An increasing proportion of MRSA amongst S. aureus isolates was noted over the course of the study period.

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Authors and Affiliations

  1. Institute of Ophthalmology and Visual Science, Rutgers-New Jersey Medical School, Newark, NJ, USA

    Jonathan I. Huz

  2. New York University School of Medicine, New York, NY, USA

    Jonathan I. Huz, Ivelisse Rodriguez Pagan & Michael Engelbert

  3. Vitreous Retina Macula Consultants of New York, 460 Park Avenue, New York, NY, 10022, USA

    Krishna Mukkamala & Michael Engelbert

  4. New York Eye and Ear Infirmary of Mount Sinai, New York, NY, USA

    David Ritterband, Mahendra Shah & Ronald C. Gentile

Authors
  1. Jonathan I. Huz
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  2. Krishna Mukkamala
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  3. Ivelisse Rodriguez Pagan
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  4. David Ritterband
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  5. Mahendra Shah
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  6. Ronald C. Gentile
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  7. Michael Engelbert
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Corresponding author

Correspondence to Michael Engelbert.

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Funding

This research was supported by The Macula Foundation, Inc.

Conflict of interest

All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge, or beliefs) in the subject matter or materials discussed in this manuscript.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. For this type of study, formal consent is not required.

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Huz, J.I., Mukkamala, K., Pagan, I.R. et al. Clinical outcomes and antibiotic susceptibilities of Staphylococcus aureus endophthalmitis. Graefes Arch Clin Exp Ophthalmol 255, 651–656 (2017). https://doi.org/10.1007/s00417-016-3504-x

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  • DOI: https://doi.org/10.1007/s00417-016-3504-x

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