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Quantitative comparison of disc rim color in optic nerve atrophy of compressive optic neuropathy and glaucomatous optic neuropathy

  • Neurophthalmology
  • Published:
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Abstract

Purpose

The purpose was to investigate an objective and quantitative method to estimate the redness of the optic disc neuroretinal rim, and to determine the usefulness of this method to differentiate compressive optic neuropathy (CON) from glaucomatous optic neuropathy (GON).

Methods

In our study there were 126 eyes: 40 with CON, 40 with normal tension glaucoma (NTG), and 46 normal eyes (NOR). Digital color fundus photographs were assessed for the redness of disc rim color using ImageJ software. We separately measured the intensity of red, green, and blue pixels from RGB images. Three disc color indices (DCIs), which indicate the redness intensity, were calculated through existing formulas.

Results

All three DCIs of CON were significantly smaller than those of NOR (P < 0.001). In addition, when compared with NTG, DCIs were also significantly smaller in CON (P < 0.05). A comparison of mild CON and mild NTG (mean deviation (MD) > -6 dB), in which the extent of retinal nerve fiber layer thinning is comparable, the DCIs of mild CON were significantly smaller than those of mild NTG (P < 0.05). In contrast, DCIs did not differ between moderate-to-severe stages of CON and NTG (MD ≤ -6 dB), though the retinal nerve fibers of CON were more severely damaged than those of NTG. To differentiate between mild CON and mild NTG, all AUROCs for the three DCIs were above 0.700.

Conclusions

A quantitative and objective assessment of optic disc color was useful in differentiating early-stage CON from GON and NOR.

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Authors and Affiliations

  1. Department of Ophthalmology and Visual Sciences, Kyoto University, 54 Shougoin Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan

    Eri Nakano, Masayuki Hata, Akio Oishi, Kazuaki Miyamoto, Akihito Uji, Masahiro Fujimoto, Manabu Miyata & Nagahisa Yoshimura

Authors
  1. Eri Nakano
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  2. Masayuki Hata
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  3. Akio Oishi
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  4. Kazuaki Miyamoto
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  5. Akihito Uji
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  6. Masahiro Fujimoto
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  7. Manabu Miyata
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  8. Nagahisa Yoshimura
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Corresponding author

Correspondence to Masayuki Hata.

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Funding

The Japan Society for the Promotion of Science (JSPS), Tokyo, Japan (Grant-in-Aid for Scientific Research, No. 21592256), the Japan National Society for the Prevention of Blindness, Tokyo, Japan, and the Innovative Techno-Hub for Integrated Medical Bio-Imaging of the Project for Developing Innovation Systems, from the Ministry of Education, Culture, Sports, Science and Technology (MEXT) in Japan provided financial support. The sponsor had no role in the design or the conduct of this research.

Conflict of interest

M. Hata, E. Nakano, K. Miyamoto, A. Uji, M. Fujimoto, and M. Miyata have no conflicts of interest. A. Oishi received lecture fees from several companies including Novartis (Basel, Switzerland) and Bayer (Leverkusen, Germany). N. Yoshimura received grants and personal fees, not related to the submitted work, from Nidek, Canon, Novartis Japan, Bayer, Santen, Senju, Ohtsuka, Wakamoto, and Alcon Japan and grants from Topcon and the Japan Society for the Promotion of Science.

Ethical approval

For this type of study, formal consent is not required.

The authors have full control of all primary data and they agree to allow Graefe’s Archive for Clinical and Experimental Ophthalmology to review their data upon request.

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Nakano, E., Hata, M., Oishi, A. et al. Quantitative comparison of disc rim color in optic nerve atrophy of compressive optic neuropathy and glaucomatous optic neuropathy. Graefes Arch Clin Exp Ophthalmol 254, 1609–1616 (2016). https://doi.org/10.1007/s00417-016-3366-2

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  • DOI: https://doi.org/10.1007/s00417-016-3366-2

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