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Monthly microperimetry (MP1) measurement of macular sensitivity after dexamethasone implantation (Ozurdex) in retinal vein occlusions

  • Retinal Disorders
  • Published:
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Abstract

Purpose

To evaluate changes in macular sensitivity as measured via microperimetry (MP) in patients with macular edema (ME) secondary to retinal vein occlusion (RVO) after dexamethasone implantation (DEX implantation, Ozurdex), in comparison to distance visual acuity, reading ability, and spectral domain optical coherence tomography (SD-OCT).

Methods

Twenty-three patients with ME secondary to RVO were treated with a DEX implantation in this prospective, observational case study. Patients were controlled at baseline and then monthly with microperimetry and assessment of distance visual acuity, reading ability, and SD- OCT. Side effects of the DEX implant were monitored by measuring the intraocular pressure (IOP) and lens grading with Lens Opacities Classification System (LOCS) charts.

Results

The 23 patients with RVO included 16 patients with branch retinal vein occlusion (BRVO) and 7 patients with central retinal vein occlusion (CRVO). Improvement in distance visual acuity, reading ability, and in central 8-points microperimetry showed statistical significance from month 1 to 3, whereas the 40-points microperimetry improved with statistical significance from month 1 to 2. The reduction of central retinal thickness measured with SD-OCT remained statistically significant until month 4. Subgroup analysis of patients with BRVO and CRVO confirmed the best test results observed at month two after DEX implantation.

Conclusions

The highest macular sensitivity was measured two months after DEX implantation. This corresponds to the best test results for distance visual acuity, reading ability, and SD-OCT observed two months after treatment.

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References

  1. Feltgen N, Pielen A, Hansen L, Bertram B, Agostini H, Jaissle GB, Hoerauf H, Stahl A (2010) Intravitreal drug therapy for retinal vein occlusion-pathophysiological mechanisms and routinely used drugs. Klin Monatsbl Augenheilkd 227:681–93

  2. Hansen L, Feltgen N (2012) Central retinal vein occlusion, Branch retinal vein occlusion. In: Joussen AM (ed) Retinal vascular disease, 1st edn Springer Verlag Berlin Heidelberg pp 189–224

  3. Haller JA, Bandello F, Belfort R, Study Group OZURDEX GENEVA STUDY GROUP et al (2010) Randomized, sham- controlled trail of dexamethasone intravitreal implant in patients with macular edema due to retinal vein occlusion. Ophthalmology 117(6):1134–46

  4. Haller JA, Bandello F, Belfort R, Blumenkranz MS, Gillies M, Heier J, Loewenstein A, Hee Yoon Y, Jiao J et al (2011) For the Ozurdex GENEVA Study Group Dexamethasone Intravitreal Implant in Patients with Macular Edema Related to Branch or Central Retinal vein Occlusion. Ophthalmology 118(12):2453–60

    Article  PubMed  Google Scholar 

  5. Chang Lin JE, Attar M, Acheampong AA, Robinson MR, Whitcup SM, Kuppermann BD, Welty D (2011) Pharmacokinetics and pharmacodynamics of a sustained- release dexamethasone intravitreal implant. Invest Ophthalmol Vis Sci 52(1):80–6

    Article  CAS  PubMed  Google Scholar 

  6. Mathew R, Pearce E, Muniraju R, Abdul-HeyA Sivaparasad S (2014) Monthly OCT monitoring of Ozurdex for macular oedema related to retinal vascular diseases: re-treatment strategy (OCTOME Report 1). Eye 28(3):318–26

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  7. Parodi MB, Iacono P, De Benedetto U et al (2012) Rebound effect after intravitreal dexamethasone implant for the treatment of macular edema secondary to central retinal vein occlusion. J Ocul Pharmacol Ther 28:566–8

    CAS  PubMed  Google Scholar 

  8. Querques L, Querques G, Lattanzio R, Gigante SR, Del Turco C, Corradetti G, Cascavilla ML, Bandello F (2013) Repeated intravitreal dexamethasone implant (Ozurdex) for retinal vein occlusion. Ophthalmologica 229(1):21–5

  9. Ferris FL, Kassoff A, Bresmick GH, Bailey I (1982) New visual acuity charts for clinical research. Am J Ophthalmol 94:91–96

    Article  PubMed  Google Scholar 

  10. Markowitz SN, Reyes SV (2013) Microperimetry and clinical practive: an evidence- based review. Can J Ophthalmol 48(5):350–7

    Article  PubMed  Google Scholar 

  11. Winterhalter S, Lux A, Maier AK, Scholz C, Heußen FMA, Huber KK, Joussen AM (2012) Microperimetry as a routine diagnostic test in the follow- up of retinal vein occlusion? Graefes Arch Clin Exp Ophthalmol 250:175–83

    Article  PubMed  Google Scholar 

  12. Du Prel JB, Hommel G, Röhrig B, Blettner M (2009) Confidence interval or p-value?: part 4 of a series on evaluation of scientific publications. Dtsch Aerztebl Int 106(19):335–9

    Google Scholar 

  13. Morwood SL (2000) Research strategies for advanced practice nurses. Prentice Hall Health, New Jersey

    Google Scholar 

  14. Kriechbaum K, Prager F, Geizenauer W, Benesch T, Schütze C, Simader C, Schmidt-Erfurth U (2009) Association of retinal sensitivity and morphology during antiangiogenic treatment of retinal vein occlusion over one year. Ophthalmology 116(12):2415–21

    Article  PubMed  Google Scholar 

  15. Mylonas G, Sacu S, Duna Völgyi R, Matt G, Blum R, Bühl W, Prünte C, Schmidt-Erfurth U (2013) Response of retinal sensitivity to ranibizumab treatment of macular edema after acute branch retinal vein occlusion. Retina 33:1220–6

    Article  CAS  PubMed  Google Scholar 

  16. Noma H, Funatsu H, Mimura T, Shimada K (2012) Macular sensitivity and morphology after intravitreal injection of triamcinolone acetonide for macular edema with branch retinal vein occlusion. Retina 32(9):1844–52

    CAS  PubMed  Google Scholar 

  17. Noma H, Shimada K, Mimura T (2012) Foveal sensitivity and morphology in major and macular branch retinal vein occlusion. Open Ophthalmol J 6:104–9

    Article  PubMed Central  PubMed  Google Scholar 

  18. Parravano M, Oddone F, Bocassini B, Giorno P, Chiaravalloti A, Tedeschi M, Scarinci F, Varano M (2014) Exploring the morphological and functional retinal changes after dexamethasone intravitreal implant (ozurdex) in macular edema due to retinal vein occlusion. Ophthalmic Res 51:153–6

  19. Querques G, Lattanzio R, Querques L, Triolo G, Cascavilla M, Cavallero E, del Turco C, Casalino G, Bandello F (2014) Impact of intravitreal dexamethasone implant (Ozurdex) on macular morphology and function. Retina 34:330–41

    Article  CAS  PubMed  Google Scholar 

  20. Senturk F, Ozdemir H, Karacorlu M, Karacorlu SA, Uysal O (2010) Microperimetric changes after intravitreal triamcinolone acetonide injection for macular edema due to central retinal vein occlusion. Retina 30(8):1254–61

    Article  PubMed  Google Scholar 

  21. Comyn O, Sivaparasad S, Pet T, Neyeu MM, Holder GE, Xing W, Bunce CV, Patel PJ, Egan CA, Bainbridge JW, Hykin PG (2014) A randomized trial to assess functional and structural effects of ranibizumab versus laser in diabetic macular edema (the LUCIDATE study). Am J Ophthalmol 157(5):960–70

    Article  CAS  PubMed  Google Scholar 

  22. Lupo St, Grenga PL, Vingolo EM (2011) Fourier-domain optical coherence tomography and microperimetry findings in retinitis pigmentosa. Am J Ophthalmol 151(1):106–11

    Article  Google Scholar 

  23. Midena E, Vujosevic St, Convento E, Manfré A, Cavarzeran F, Pilotto E (2007) Microperimetry and fundus autofluorescence in patients with early age-related macular degeneration. BrJ Ophthalmol 91(11):1499–503

    Article  Google Scholar 

  24. Reznicek L, Cserhati S, Seidensticker F, Liegl R, Kampik A, Ulbig M, Neubauer AS, Kernt M (2013) Functional and morphological changes in diabetic macular edema over the course of anti-vascular endothelial growth factor treatment. Acta Ophthalmol 91(7):e529–36. doi:10.1111/aos.12153

    Article  CAS  PubMed  Google Scholar 

  25. Seidensticker F, Reznicek L, Cserhati S, Liegl RG, Langer J, Wolf A, Kampik A, Ulbig M, Haritoglou C, Kernt M (2013) Improvement of fixation in diabetic macular oedema patients under intravitreal ranibizumab treatment. Klin Monbl Augenheilkd 230(5):524–9

    CAS  PubMed  Google Scholar 

  26. Wu Z, Ayton LN, Luu CD, Guymer RH (2014) Relationship between retinal microstructures on optical coherence tomography and microperimetry in age-related macular degeneration. Ophthalmology 121(7):1445–52

    Article  PubMed  Google Scholar 

  27. Munk MR, Kiss CG, Steiner I et al (2013) Systemic correlation of morphologic alterations and retinal function in eyes with uveitis- associated cystoid macular oedema during development, resolution and relapse. BrJ Ophthalmol 97:1289–96

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Authors and Affiliations

  1. Department of Ophthalmology Charité Virchowklinikum, University of Berlin, Augustenburger Platz 1, 13353, Berlin, Germany

    Sibylle Winterhalter, Gerrit Alexander vom Brocke, Matthias K. Klamann, Bert Müller & Antonia M. Joussen

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  1. Sibylle Winterhalter
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  2. Gerrit Alexander vom Brocke
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  3. Matthias K. Klamann
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  4. Bert Müller
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  5. Antonia M. Joussen
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Correspondence to Sibylle Winterhalter.

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Winterhalter, S., vom Brocke, G.A., Klamann, M.K. et al. Monthly microperimetry (MP1) measurement of macular sensitivity after dexamethasone implantation (Ozurdex) in retinal vein occlusions. Graefes Arch Clin Exp Ophthalmol 253, 1873–1882 (2015). https://doi.org/10.1007/s00417-014-2897-7

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  • DOI: https://doi.org/10.1007/s00417-014-2897-7

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