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Femtosecond laser treatment of the crystalline lens: a 1-year study of possible cataractogenesis in minipigs

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Abstract

Background

To investigate the long-term stability and possible cataractogenesis after femtosecond laser treatment of the crystalline lens.

Methods

The crystalline lenses of ten Göttingen minipigs® underwent femtosecond laser treatment. During a subsequent 1-year follow-up, the pigs were monitored by means of slit-lamp examination of the anterior segment and Scheimpflug imaging of the lens.

Results

No laser-induced cataractogenesis was observed during the 1-year follow-up. The laser pattern showed a stable appearance under all examination devices.

Conclusion

Femtosecond laser treatment seems to be no trigger for cataract formation. Moreover, the long-term stability of the laser pattern makes it suitable for applications such as presbyopia treatment.

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Acknowledgement

This work is supported by the German Federal Ministry of Education and Research (Grant-IDs: 13 N8831, 13 N8835). We are also grateful to Dr. Matthias Reich for his assistance during the preparation of this study.

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Authors and Affiliations

  1. Institute of Applied Physics, Friedrich-Schiller-Universität Jena, Max-Wien-Platz 1, 07743, Jena, Germany

    Roland Ackermann, Robert Kammel, Stephanie C. Bühren & Stefan Nolte

  2. Department of Ophthalmology, HELIOS Klinikum Erfurt GmbH, Nordhäuser Str. 74, 99089, Erfurt, Germany

    Kathleen S. Kunert & Marcus Blum

  3. Institute of Laboratory Animal Science, Friedrich-Schiller-Universität Jena, Dornburger Str. 23, 07743, Jena, Germany

    Sabine Bischoff & Harald Schubert

Authors
  1. Roland Ackermann
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  2. Kathleen S. Kunert
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  3. Robert Kammel
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  4. Sabine Bischoff
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  5. Stephanie C. Bühren
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  6. Harald Schubert
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  7. Marcus Blum
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  8. Stefan Nolte
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Corresponding author

Correspondence to Roland Ackermann.

Additional information

None of the authors have any financial or proprietary interest in any material or method mentioned. The authors declare that they have full control of all primary data. They agree to allow Graefe’s Archive for Clinical and Experimental Ophthalmology to review their data upon request.

Parts of the content were presented as posters at the Annual Meeting 2010 of the Association for Research in Vision and Ophthalmology (ARVO) and the 5th European Meeting on Visual and Physiological Optics (EMVPO) 2010.

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Ackermann, R., Kunert, K.S., Kammel, R. et al. Femtosecond laser treatment of the crystalline lens: a 1-year study of possible cataractogenesis in minipigs. Graefes Arch Clin Exp Ophthalmol 249, 1567–1573 (2011). https://doi.org/10.1007/s00417-011-1772-z

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  • DOI: https://doi.org/10.1007/s00417-011-1772-z

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