Journal of Neurology

, Volume 263, Issue 4, pp 677–688

Taste dysfunction in multiple sclerosis

  • Richard L. Doty
  • Isabelle A. Tourbier
  • Dzung L. Pham
  • Jennifer L. Cuzzocreo
  • Jayaram K. Udupa
  • Bilge Karacali
  • Evan Beals
  • Laura Fabius
  • Fidias E. Leon-Sarmiento
  • Gul Moonis
  • Taehoon Kim
  • Toru Mihama
  • Rena J. Geckle
  • David M. Yousem
Original Communication

DOI: 10.1007/s00415-016-8030-6

Cite this article as:
Doty, R.L., Tourbier, I.A., Pham, D.L. et al. J Neurol (2016) 263: 677. doi:10.1007/s00415-016-8030-6

Abstract

Empirical studies of taste function in multiple sclerosis (MS) are rare. Moreover, a detailed assessment of whether quantitative measures of taste function correlate with the punctate and patchy myelin-related lesions found throughout the CNS of MS patients has not been made. We administered a 96-trial test of sweet (sucrose), sour (citric acid), bitter (caffeine) and salty (NaCl) taste perception to the left and right anterior (CN VII) and posterior (CN IX) tongue regions of 73 MS patients and 73 matched controls. The number and volume of lesions were assessed using quantitative MRI in 52 brain regions of 63 of the MS patients. Taste identification scores were significantly lower in the MS patients for sucrose (p = 0.0002), citric acid (p = 0.0001), caffeine (p = 0.0372) and NaCl (p = 0.0004) and were present in both anterior and posterior tongue regions. The percent of MS patients with identification scores falling below the 5th percentile of controls was 15.07 % for caffeine, 21.9 % for citric acid, 24.66 % for sucrose, and 31.50 % for NaCl. Such scores were inversely correlated with lesion volumes in the temporal, medial frontal, and superior frontal lobes, and with the number of lesions in the left and right superior frontal lobes, right anterior cingulate gyrus, and left parietal operculum. Regardless of the subject group, women outperformed men on the taste measures. These findings indicate that a sizable number of MS patients exhibit taste deficits that are associated with MS-related lesions throughout the brain.

Keywords

Multiple sclerosisMagnetic resonance imagingTasteChemosensory transductionTaste disordersSex differences

Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  • Richard L. Doty
    • 1
    • 2
  • Isabelle A. Tourbier
    • 1
    • 2
  • Dzung L. Pham
    • 3
  • Jennifer L. Cuzzocreo
    • 4
  • Jayaram K. Udupa
    • 5
  • Bilge Karacali
    • 6
  • Evan Beals
    • 1
    • 7
  • Laura Fabius
    • 1
    • 2
  • Fidias E. Leon-Sarmiento
    • 1
    • 2
  • Gul Moonis
    • 8
  • Taehoon Kim
    • 1
    • 2
  • Toru Mihama
    • 1
    • 2
  • Rena J. Geckle
    • 9
  • David M. Yousem
    • 9
  1. 1.Smell and Taste Center, Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaUSA
  2. 2.Department of Otorhinolarynology: Head and Neck Surgery, Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaUSA
  3. 3.Center for Neuroscience and Regenerative MedicineHenry Jackson FoundationBethesdaUSA
  4. 4.Department of NeurologyJohns Hopkins School of MedicineBaltimoreUSA
  5. 5.Medical Imaging Section, Department of RadiologyPerelman School of Medicine, University of PennsylvlaniaPhiladelphiaUSA
  6. 6.Electrical and Electronics Engineering Departmentİzmir Institute of TechnologyUrla, IzmirTurkey
  7. 7.Department of PsychologyMichigan State UniversityEast LansingUSA
  8. 8.Department of RadiologyColumbia University Medical CenterNew YorkUSA
  9. 9.Department of RadiologyThe Johns Hopkins HospitalBaltimoreUSA