Skip to main content

Advertisement

Log in

Retrograde degeneration of visual pathway: hemimacular thinning of retinal ganglion cell layer in progressive and active multiple sclerosis

  • Letter to the Editors
  • Published:
Journal of Neurology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2

References

  1. Gupta N, Greenberg G, Noël de Tilly L, Gray B, Polemidiotis M, Yücel YH (2009) Atrophy of the lateral geniculate nucleus in human glaucoma detected by magnetic resonance imaging. Br J Ophthalmol 93:56–60

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  2. Audoin B, Fernando KT, Swanton JK, Thompson AJ, Plant GT, Miller DH (2006) Selective magnetization transfer ratio decrease in the visual cortex following optic neuritis. Brain 129(Pt 4):1031–1039

    Article  PubMed  Google Scholar 

  3. Rocca MA, Mesaros S, Preziosa P, Pagani E, Stosic-Opincal T, Dujmovic-Basuroski I, Drulovic J, Filippi M (2013) Wallerian and trans-synaptic degeneration contribute to optic radiation damage in multiple sclerosis: a diffusion tensor MRI study. Mult Scler 19:1610–1617

    Article  PubMed  Google Scholar 

  4. Pfueller CF, Brandt AU, Schubert F, Bock M, Walaszek B, Waiczies H, Schwenteck T, Dörr J, Bellmann-Strobl J, Mohr C, Weinges-Evers N, Ittermann B, Wuerfel JT, Paul F (2011) Metabolic changes in the visual cortex are linked to retinal nerve fiber layer thinning in multiple sclerosis. PLoS One 6(4):e18019. doi:10.1371/journal.pone.0018019

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  5. Balk LJ, Twisk JW, Steenwijk MD, Daams M, Tewarie P, Killestein J, Uitdehaag BM, Polman CH, Petzold A (2014) A dam for retrograde axonal degeneration in multiple sclerosis? J Neurol Neurosurg Psychiatry 85:782–789

    Article  CAS  PubMed  Google Scholar 

  6. Gabilondo I, Martínez-Lapiscina EH, Martínez-Heras E, Fraga-Pumar E, Llufriu S, Ortiz S, Bullich S, Sepulveda M, Falcon C, Berenguer J, Saiz A, Sanchez-Dalmau B, Villoslada P (2014) Trans-synaptic axonal degeneration in the visual pathway in multiple sclerosis. Ann Neurol 75:98–107

    Article  CAS  PubMed  Google Scholar 

  7. Klistorner A, Sriram P, Vootakuru N, Wang C, Barnett MH, Garrick R, Parratt J, Levin N, Raz N, Van der Walt A, Masters L, Graham SL, Yiannikas C (2014) Axonal loss of retinal neurons in multiple sclerosis associated with optic radiation lesions. Neurology 82:2165–2172

    Article  PubMed Central  PubMed  Google Scholar 

  8. Sinnecker T, Oberwahrenbrock T, Metz I, Zimmermann H, Pfueller CF, Harms L, Ruprecht K, Ramien C, Hahn K, Brück W, Niendorf T, Paul F, Brandt AU, Dörr J, Wuerfel J (2014) Optic radiation damage in multiple sclerosis is associated with visual dysfunction and retinal thinning––an ultrahigh-field MR pilot study. Eur Radiol. doi:10.1007/s00330-014-3358-8

    PubMed  Google Scholar 

  9. Romero RS, Gutierrez I, Wang E, Reder AT, Bhatti MT, Bernard JT, Javed A (2012) Homonymous hemimacular thinning: a unique presentation of optic tract injury in neuromyelitis optica. J Neuroophthalmol 32:150–153

    Article  PubMed  Google Scholar 

  10. Bermel RA, Villoslada P (2014) Retrograde trans-synaptic degeneration in MS: a missing link? Neurology 82:2152–2153

    Article  PubMed  Google Scholar 

  11. Plant GT, Kermode AG, Turano G, Moseley IF, Miller DH, MacManus DG, Halliday AM, McDonald WI (1992) Symptomatic retrochiasmal lesions in multiple sclerosis: clinical features, visual evoked potentials, and magnetic resonance imaging. Neurology 42:68–76

    Article  CAS  PubMed  Google Scholar 

  12. Millington RS, Yasuda CL, Jindahra P, Jenkinson M, Barbur JL, Kennard C, Cendes F, Plant GT, Bridge H (2014) Quantifying the pattern of optic tract degeneration in human hemianopia. J Neurol Neurosurg Psychiatry 85:379–386

    Article  PubMed  Google Scholar 

Download references

Acknowledgement

The authors gratefully acknowledge financial support from Linköping University and County Council of Östergötland, Sweden.

Conflicts of interest

The authors declare no conflict of interests.

Ethical standard

The study was approved by the Ethical Committee of the Linköping University, Sweden, study number is 2013/141-31.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Yu-Min Huang-Link.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Huang-Link, YM., Al-Hawasi, A. & Eveman, I. Retrograde degeneration of visual pathway: hemimacular thinning of retinal ganglion cell layer in progressive and active multiple sclerosis. J Neurol 261, 2453–2456 (2014). https://doi.org/10.1007/s00415-014-7538-x

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00415-014-7538-x

Keywords

Navigation