Abstract
Critical illness may affect the autonomic nervous system. Decreased cardiovascular autonomic function measured by heart rate variability (HRV) has been reported in critically ill patients but limited information exists about other autonomic functions. The cold face test (CFT) and skin wrinkle test (SWT) have never been investigated in critically ill patients. Feasibility and safety of the CFT and SWT were investigated in critically ill patients. Exclusion criteria: polyneuropathy, autonomic neuropathy, admission after stroke, spinal cord injury or cardiac arrest. For the CFT, a cold pack was applied to the forehead to measure the maximal increase in RR interval. The simulated SWT was used and wrinkling was assessed on a five-point scale. HRV was investigated using power spectral analysis of continuous 5-min ECG recordings. Twelve critically ill patients were included (mean age 54). No adverse effects for the CFT and SWT were noted. The CFT could be performed in 10 patients and showed an abnormal response in 9. The SWT could be performed in 11 patients; results were abnormal in 6. HRV analysis showed decreased HRV in all patients. CFT and HRV responses were correlated with each other, no correlation was found between SWT and CFT or HRV results. The CFT and SWT are feasible and safe in critically ill patients. Cardiovascular dysfunction may be more prevalent in critical illness than peripheral sympathetic dysfunction. Influence of confounders and further validation of these tests needs to be investigated.
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Ebersoldt M, Sharshar T, Annane D (2007) Sepsis-associated delirium. Intensive Care Med 33:941–950
Stevens RD, Dowdy DW, Michaels RK, Mendez-Tellez PA, Pronovost PJ, Needham DM (2007) Neuromuscular dysfunction acquired in critical illness: a systematic review. Intensive Care Med 33:1876–1891
Schmidt H, Hoyer D, Wilhelm J, Söffker G, Heinroth K, Hottenrott K, Said SM, Buerke M, Müller-Werdan U, Werdan K (2008) The alteration of autonomic function in multiple organ dysfunction syndrome. Crit Care Clin 24:149–163
Godin PJ, Buchman TG (1996) Uncoupling of biological oscillators: a complementary hypothesis concerning the pathogenesis of multiple organ dysfunction syndrome. Crit Care Med 24:1107–1116
Schmidt H, Mller-Werdan U, Hoffmann T, Francis DP, Piepoli MF, Rauchhaus M, Prondzinsky R, Loppnow H, Buerke M, Hoyer D, Werdan K (2005) Autonomic dysfunction predicts mortality in patients with multiple organ dysfunction syndrome of different age groups. Crit Care Med 33:1994–2002
Pontet J, Contreras P, Curbelo A, Medina J, Noveri S, Bentancourt S, Migliaro ER (2003) Heart rate variability as early marker of multiple organ dysfunction syndrome in septic patients. J Crit Care 18:156–163
Buchman TG, Stein PK, Goldstein B (2002) Heart rate variability in critical illness and critical care. Curr Opin Crit Care 8:311–315
Malik M, Camm AJ (1993) Components of heart rate variability–what they really mean and what we really measure. Am J Cardiol 72:821–822
Annane D, Trabold F, Sharshar T, Jarrin I, Blanc AS, Raphael JC, Gajdos P (1999) Inappropriate sympathetic activation at onset of septic shock: a spectral analysis approach. Am J Respir Crit Care Med 160:458–465
Hilz MJ, Dütsch M (2005) Quantitative studies of autonomic function. Muscle Nerve 33:6–20
Khurana RK, Wu R (2006) The cold face test: a non-baroreflex mediated test of cardiac vagal function. Clin Auton Res 16:202–207
Wilder-Smith EPV (2004) Water immersion wrinkling. Clin Auton Res 14:125–131
Teoh HL, Chow A, Wilder-Smith EP (2008) Skin wrinkling for diagnosing small fibre neuropathy: comparison with epidermal nerve density and sympathetic skin response. J Neurol Neurosurg Psychiatry 79:835–837
Niskanen J-P, Tarvainen MP, Ranta-aho PO, Karjalainen PA (2004) Software for advanced HRV analysis. Comput Methods Programs Biomed 76:73–81
Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology (1996) Heart rate variability. Standards of measurement, physiological interpretation, and clinical use. Eur Heart J 17:354–381
Ziegler D, Piolot R, Strassburger K, Lambeck H, Dannehl K (1999) Normal ranges and reproducibility of statistical, geometric, frequency domain, and non-linear measures of 24-hour heart rate variability. Horm Metab Res 31:672–679
Khurana RK (2007) Cold face test: adrenergic phase. Clin Auton Res 17:211–216
Reyners AKL, Tio RA, Vlutters FG, van der Woude GF, Reitsma WD, Smit AJ (2000) Re-evaluation of the cold face test in humans. Eur J Appl Physiol 82:487–492
Hilz MJ, Stemper B, Sauer P, Haertl U, Singer W, Axelrod FB (1999) Cold face test demonstrates parasympathetic cardiac dysfunction in familial dysautonomia. Am J Physiol 276:R1833–R1839
Heath ME, Downey JA (1990) The cold face test (diving reflex) in clinical autonomic assessment: methodological considerations and repeatability of responses. Clin Sci 78:139–147
Wilder-Smith E, Chow A (2003) Water immersion and EMLA cause similar digit skin wrinkling and vasoconstriction. Microvasc Res 66:68–72
Wilder-Smith EP, Guo Y, Chow A (2009) Stimulated skin wrinkling for predicting intraepidermal nerve fibre density. Clin Neurophysiol 120:953–958
Lippman N, Stein KM, Lerman BB (1994) Comparison of methods for removal of ectopy in measurement of heart rate variability. Am J Physiol 267:H411–H418
Salo MA, Huikuri HV, Seppänen T (2001) Ectopic beats in heart rate variability analysis: effects of editing on time and frequency domain measures. Ann Noninvasive Electrocardiol 6:5–17
Kox M, Ramakers BP, Pompe JC, van der Hoeven JG, Hoedemaekers CW, Pickkers P (2011) Interplay between the acute inflammatory response and heart rate variability in healthy human volunteers. Shock 36:115–120
Bolton C, Thompson J, Bernardi L, Voll C, Young B (2007) The cardiac R-R variation and sympathetic skin response in the intensive care unit. Can J Neurol Sci 34:313–315
Zochodne DW, Bolton CF, Wells GA, Gilbert JJ, Hahn AF, Brown JD, Sibbald WA (1987) Critical illness polyneuropathy. A complication of sepsis and multiple organ failure. Brain 110:819–841
Sharshar T, Gray F, Lorin de la Grandmaison G, Hopkinson NS, Ross E, Dorandeu A, Orlikowski D, Raphael JC, Gajdos P, Annane D (2003) Apoptosis of neurons in cardiovascular autonomic centres triggered by inducible nitric oxide synthase after death from septic shock. Lancet 362:1799–1805
Zorn-Pauly K, Pelzmann B, Lang P, Mchler H, Schmidt H, Ebelt H, Werdan K, Koidl B, Mller-Werdan U (2007) Endotoxin impairs the human pacemaker current IF. Shock 28:655–661
Eisenhut M (2012) Inflammation-induced desensitization of β-receptors in acute lung injury. Am J Respir Crit Care Med 185:894–895
Acknowledgments
The authors thank G. Sussenbach for his work on development of the HRV recording equipment and software. This research was performed within the framework of CTMM, the Center for Translational Molecular Medicine (http://www.ctmm.nl), project MARS (grant 04I-201). Dr. L. Wieske is supported by a personal grant from the Netherlands Organization for Health Research and Development (ZonMw–AGIKO grant [project number 40-00703-98-11636]).
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The authors declare that they have no conflict of interest.
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This study has been approved by the appropriate ethics committee and has therefore been performed in accordance with the 2008 Declaration of Helsinki.
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Wieske, L., Kiszer, E.R., Schultz, M.J. et al. Examination of cardiovascular and peripheral autonomic function in the ICU: a pilot study. J Neurol 260, 1511–1517 (2013). https://doi.org/10.1007/s00415-012-6818-6
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DOI: https://doi.org/10.1007/s00415-012-6818-6