References
Confavreux C, Hutchinson M, Hours MM, Cortinovis-Tourniaire P, Moreau T (1998) Rate of pregnancy-related relapse in multiple sclerosis. Pregnancy in Multiple Sclerosis Group. N Engl J Med 339:285–291
Iorio R, Nociti V, Frisullo G, Patanella AK, Tonali PA, Batocchi AP (2009) Breastfeeding and multiple sclerosis. Arch Neurol 66:1580 (author reply 1581)
Langer-Gould A, Huang SM, Gupta R et al (2009) Exclusive breastfeeding and the risk of postpartum relapses in women with multiple sclerosis. Arch Neurol 66:958–963
Nelson LM, Franklin GM, Jones MC (1988) Risk of multiple sclerosis exacerbation during pregnancy and breast-feeding. JAMA 259:3441–3443
Neuteboom RF, Hintzen RQ (2011) Breast-feeding, postpartum and prepregnancy disease activity in multiple sclerosis. Neurology 76:1532 (author reply 1532–1533)
Portaccio E, Ghezzi A, Hakiki B et al (2011) Breastfeeding is not related to postpartum relapses in multiple sclerosis. Neurology 77:145–150
Worthington J, Jones R, Crawford M, Forti A (1994) Pregnancy and multiple sclerosis—a 3-year prospective study. J Neurol 241:228–233
Gulick EE, Halper J (2002) Influence of infant feeding method on postpartum relapse of mothers with MS. Int J MS Care 4:4
Airas L, Jalkanen A, Alanen A, Pirttila T, Marttila RJ (2010) Breast-feeding, postpartum and prepregnancy disease activity in multiple sclerosis. Neurology 75:474–476
Fernandez Liguori N, Klajn D, Acion L et al (2009) Epidemiological characteristics of pregnancy, delivery, and birth outcome in women with multiple sclerosis in Argentina (EMEMAR study). Mult Scler 15:555–562
Vukusic S, Hutchinson M, Hours M et al (2004) Pregnancy and multiple sclerosis (the PRIMS study): clinical predictors of post-partum relapse. Brain J Neurol 127:1353–1360
Acknowledgments
The authors would like to thank Prof. Christian Confavreux (Lyon, France), Prof. Sandra Vukusic (Lyon, France), Dr. Michael Hutchinson (Dublin, Ireland), Dr. Laura Airas (Turku, Finland) and Dr. Nora Fernández Liguori (Buenos Aires, Argentina) for kindly providing us with raw data from their studies. This work was funded by the Medical Research Council [grant no. G0801976]. No funding bodies had any role in the design and conduct of the study; collection, management, analysis and interpretation of the data; and preparation, review or approval of the manuscript.
Conflicts of interest
Ms. Pakpoor reports no disclosures. Dr. Disanto is funded by a research fellowship FISM-Fondazione Italiana Sclerosi Multipla-Cod.: 2010/B/5. Ms. Lacey reports no disclosures. Dr. Hellwig has received speaker honoraria and research support from Bayer Schering Pharma, Merck Serono, Biogen Idec, Pfizer Inc., Teva Pharmaceutical Industries Ltd.-Sanofi-Aventis. Prof. Giovannoni serves on scientific advisory boards for Merck Serono, Biogen Idec and Vertex Pharmaceuticals; served on the editorial board of Multiple Sclerosis; has received speaker honoraria from Bayer Schering Pharma, Merck Serono, Biogen Idec, Pfizer Inc., Teva Pharmaceutical Industries Ltd.–Sanofi-Aventis, Vertex Pharmaceuticals, Genzyme Corp., Ironwood and Novartis; has served as a consultant for Bayer Schering Pharma, Biogen Idec, GlaxoSmithKline, Merck Serono, Protein Discovery Laboratories, Teva Pharmaceutical Industries Ltd.–Sanofi-Aventis, UCB, Vertex Pharmaceuticals, GW Pharma, Novartis and FivePrime; serves on the speakers bureau for Merck Serono; and has received research support from Bayer Schering Pharma, Biogen Idec, Merck Serono, Novartis, UCB, Merz Pharmaceuticals, LLC, Teva Pharmaceutical Industries Ltd.–Sanofi-Aventis, GW Pharma and Ironwood. Dr. Ramagopalan receives research support from the Multiple Sclerosis Society of the UK.
Author information
Authors and Affiliations
Corresponding author
Electronic supplementary material
Below is the link to the electronic supplementary material.
Rights and permissions
About this article
Cite this article
Pakpoor, J., Disanto, G., Lacey, M.V. et al. Breastfeeding and multiple sclerosis relapses: a meta-analysis. J Neurol 259, 2246–2248 (2012). https://doi.org/10.1007/s00415-012-6553-z
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00415-012-6553-z