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Impact of Radiation Therapy in Surgically Resected Limited-Stage Small Cell Lung Carcinoma

  • Lung Cancer
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Abstract

Purpose

To elucidate the role of radiation therapy (RT) in the treatment of surgically resected limited-stage small cell lung carcinoma (LSCLC).

Methods

We queried the SEER database from 1998 to 2012 to identify patients who were diagnosed with LSCLC as their only primary tumor. Kaplan–Meier analysis was utilized to determine disease-specific survival (DSS) and overall survival (OS), while multivariate analysis was used to compare survival in terms of patients and treatment characteristics.

Results

Eight hundred twenty-three LSCLC patients were identified for inclusion within the study. 12-month DSS for patients who did not receive surgery or RT was 31.9% (95% CI 27.7–36.3), 93.3% (95% CI 71.6–90.5) for surgery alone, and 81.0% (95% CI 69.3–88.6) for surgery + RT. 12-month OS was 27.2% (95% CI 23.4–31.1), 74.7% (95% CI 62.6–83.4), and 78.3% (95% CI 66.4–86.4) for no surgery or RT, for surgery alone, and for surgery + RT, respectively. In terms of multivariate analysis, patients receiving surgery alone and patients receiving surgery + RT had a better DSS and OS than those who received neither treatment. However, OS (HR 1.60; 95% CI 0.93–2.75, p = 0.09) and DSS (HR 1.34; 95% CI 0.72–2.51, p = 0.37) were not significantly associated with patients receiving surgery alone compared to surgery + RT.

Conclusions

Surgery alone and surgery + RT were positively associated with DSS and OS compared to patients who did not receive surgery or RT. However, the addition of RT to surgery did not significantly predict DSS or OS compared to surgery alone.

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Funding

Dr. Paul Christos was partially supported by the following grant: Clinical and Translational Science Center at Weill Cornell Medical College (UL1-TR000457-06).

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Authors and Affiliations

  1. Department of Radiation Oncology, Stitch Radiation Center, Weill Cornell Medical Center, New York, NY, 10065, USA

    Samuel K. Kim, Julia Manzerova, A. Gabriella Wernicke & Bhupesh Parashar

  2. Department of Biostatistics and Epidemiology, Weill Cornell Medical Center, New York, NY, 10065, USA

    Paul Christos

  3. New York Presbyterian Hospital, Weill Cornell Medical Center, 525 E 68th St, New York, NY, 10021, USA

    Bhupesh Parashar

Authors
  1. Samuel K. Kim
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  2. Julia Manzerova
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  3. Paul Christos
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  4. A. Gabriella Wernicke
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  5. Bhupesh Parashar
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Corresponding author

Correspondence to Bhupesh Parashar.

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Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed Consent

This is a retrospective database study and informed consent was not required for this study.

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Kim, S.K., Manzerova, J., Christos, P. et al. Impact of Radiation Therapy in Surgically Resected Limited-Stage Small Cell Lung Carcinoma. Lung 195, 341–346 (2017). https://doi.org/10.1007/s00408-017-9992-6

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  • DOI: https://doi.org/10.1007/s00408-017-9992-6

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