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Clinical Outcomes in Patients with Acute Eosinophilic Pneumonia Not Treated with Corticosteroids

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Abstract

Purpose

The objective of this study was to evaluate the course of clinical stability in patients with acute eosinophilic pneumonia (AEP) who did not receive corticosteroid treatment.

Methods

Secondary analysis included 19 consecutive patients with AEP who did not receive corticosteroid treatment from a cohort of 310 patients newly diagnosed with AEP between October 2007 and December 2013.

Results

All patients presented with dyspnea, fever, or cough with diffuse pulmonary infiltration. All but one patient (95 %) had elevated C-reactive protein (CRP), and 11 (58 %) patients had peripheral eosinophilia at the time of diagnosis. During the follow-up period, the dyspnea improved within a median of 4 (3–6) days and defervescence occurred within a median of 5 (4–7) days. Median time to clinical stability (defined as disappearance of all initial presenting symptoms) was 9 (7–12) days. In addition, the majority of pulmonary infiltrates on chest radiographs completely disappeared within 14 days after diagnosis. However, the peripheral eosinophil count and the frequency of peripheral eosinophilia increased up to 10 days and then decreased during the follow-up period. All patients experienced peripheral eosinophilia during hospitalisation.

Conclusion

AEP-associated symptoms and radiographic abnormalities were resolved completely within 2 weeks after diagnosis even when corticosteroid treatment was not initiated. However, these findings might be limited to relatively mild cases of AEP.

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References

  1. Allen JN, Pacht ER, Gadek JE et al (1989) Acute eosinophilic pneumonia as a reversible cause of noninfectious respiratory failure. N Engl J Med 321:569–574. doi:10.1056/nejm198908313210903

    Article  CAS  PubMed  Google Scholar 

  2. Hayakawa H, Sato A, Toyoshima M et al (1994) A clinical study of idiopathic eosinophilic pneumonia. Chest 105:1462–1466

    Article  CAS  PubMed  Google Scholar 

  3. Philit F, Etienne-Mastroianni B, Parrot A et al (2002) Idiopathic acute eosinophilic pneumonia: a study of 22 patients. Am J Respir Crit Care Med 166:1235–1239. doi:10.1164/rccm.2112056

    Article  PubMed  Google Scholar 

  4. Kawayama T, Fujiki R, Morimitsu Y et al (2002) Fatal idiopathic acute eosinophilic pneumonia with acute lung injury. Respirology 7:373–375

    Article  PubMed  Google Scholar 

  5. Lim SY, Suh GY, Jeon K (2012) Acute eosinophilic pneumonia presenting as life-threatening hypoxaemia necessitating extracorporeal membrane oxygenation. Int J Tuberc Lung Dis 16:1711–1712. doi:10.5588/ijtld.12.0555

    Article  PubMed  Google Scholar 

  6. Allen J (2006) Acute eosinophilic pneumonia. Semin Respir Crit Care Med 27:142–147. doi:10.1055/s-2006-939517

    Article  PubMed  Google Scholar 

  7. Umeki S, Soejima R (1992) Acute and chronic eosinophilic pneumonia: clinical evaluation and the criteria. Intern Med 31:847–856

    Article  CAS  PubMed  Google Scholar 

  8. Pope-Harman AL, Davis WB, Allen ED et al (1996) Acute eosinophilic pneumonia. A summary of 15 cases and review of the literature. Medicine (Baltimore) 75:334–342

    Article  CAS  Google Scholar 

  9. Uchiyama H, Suda T, Nakamura Y et al (2008) Alterations in smoking habits are associated with acute eosinophilic pneumonia. Chest 133:1174–1180. doi:10.1378/chest.07-2669

    Article  PubMed  Google Scholar 

  10. Rhee CK, Min KH, Yim NY et al (2013) Clinical characteristics and corticosteroid treatment of acute eosinophilic pneumonia. Eur Respir J 41:402–409. doi:10.1183/09031936.00221811

    Article  CAS  PubMed  Google Scholar 

  11. Halm EA, Fine MJ, Marrie TJ et al (1998) Time to clinical stability in patients hospitalized with community-acquired pneumonia: implications for practice guidelines. JAMA 279:1452–1457

    Article  CAS  PubMed  Google Scholar 

  12. Daimon T, Johkoh T, Sumikawa H et al (2008) Acute eosinophilic pneumonia: thin-section CT findings in 29 patients. Eur J Radiol 65:462–467. doi:10.1016/j.ejrad.2007.04.012

    Article  PubMed  Google Scholar 

  13. Shorr AF, Scoville SL, Cersovsky SB et al (2004) Acute eosinophilic pneumonia among US Military personnel deployed in or near Iraq. JAMA 292:2997–3005. doi:10.1001/jama.292.24.2997

    Article  CAS  PubMed  Google Scholar 

  14. Shiota Y, Kawai T, Matsumoto H et al (2000) Acute eosinophilic pneumonia following cigarette smoking. Intern Med 39:830–833

    Article  CAS  PubMed  Google Scholar 

  15. Watanabe K, Fujimura M, Kasahara K et al (2002) Acute eosinophilic pneumonia following cigarette smoking: a case report including cigarette-smoking challenge test. Intern Med 41:1016–1020

    Article  PubMed  Google Scholar 

  16. Kitahara Y, Matsumoto K, Taooka Y et al (2003) Cigarette smoking-induced acute eosinophilic pneumonia showing tolerance in broncho-alveolar lavage findings. Intern Med 42:1016–1021

    Article  PubMed  Google Scholar 

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Conflict of interest

On behalf of all authors, the corresponding author states that there is no conflict of interest.

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Authors and Affiliations

  1. Division of Pulmonary and Critical Care Medicine, Department of Medicine and Critical Care Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 135-710, Republic of Korea

    Byung Woo Jhun, Hongseok Yoo, Byeong-Ho Jeong, Man Pyo Chung & Kyeongman Jeon

  2. Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, The Armed Forces Capital Hospital, Seongnam, Republic of Korea

    Byung Woo Jhun & Se Jin Kim

  3. Department of Radiology, The Armed Forces Capital Hospital, Seongnam, Republic of Korea

    Rak Chae Son

  4. Department of Critical Care Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea

    Kyeongman Jeon

Authors
  1. Byung Woo Jhun
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  2. Se Jin Kim
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  3. Rak Chae Son
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  4. Hongseok Yoo
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  5. Byeong-Ho Jeong
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  6. Man Pyo Chung
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  7. Kyeongman Jeon
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Corresponding author

Correspondence to Kyeongman Jeon.

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Jhun, B.W., Kim, S.J., Son, R.C. et al. Clinical Outcomes in Patients with Acute Eosinophilic Pneumonia Not Treated with Corticosteroids. Lung 193, 361–367 (2015). https://doi.org/10.1007/s00408-015-9722-x

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  • DOI: https://doi.org/10.1007/s00408-015-9722-x

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