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Association Between Vitamin D Status and COPD Phenotypes

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Abstract

Background

It has been suggested that identifying phenotypes in chronic obstructive pulmonary disease (COPD) might improve treatment outcome and the accuracy of prediction of prognosis. In observational studies vitamin D deficiency has been associated with decreased pulmonary function, presence of emphysema and osteoporosis, upper respiratory tract infections, and systemic inflammation. This could indicate a relationship between vitamin D status and COPD phenotypes. The aim of this study was to assess the association between vitamin D levels and COPD phenotypes. In addition, seasonality of vitamin D levels was examined.

Methods

A total of 91 patients from a Danish subpopulation of the “Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points” cohort took part in a biomarker substudy. Vitamin D concentration was measured from blood samples taken at two visits, approximately 6 months apart. The participants were 40–75-year-old patients with COPD and had a smoking history of >10 pack-years.

Results

Fifty-six patients had 25-hydroxyvitamin D measured from blood samples from both visits. In the final model of the multivariate analyses, the factors that were associated with vitamin D deficiency at the first visit were age (OR: 0.89, p = 0.02) and summer season (OR: 3.3, p = 0.03). Factors associated with vitamin D level also at the first visit were age (B: 0.9, p = 0.02) and 6 min walking distance (B: 0.05, p = 0.01).

Conclusion

Vitamin D was not associated with COPD phenotypes and season did not seem to be a determinant of vitamin D levels in patients with moderate to severe COPD.

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Acknowledgments

Mia Moberg was funded by TrygFonden.

Conflict of interest

The authors have no conflict of interest to declare.

Ethical standards

The study complies with the currents laws of Denmark.

Author information

Authors and Affiliations

  1. Section of Respiratory Medicine, Hvidovre University Hospital, Kettegaard Allé 30, 2650, Hvidovre, Denmark

    Mia Moberg, Thomas Ringbaek & Nassim Bazeghi Roberts

  2. Department of Respiratory Medicine, Odense University Hospital, Sdr. Boulevard 29, 5000, Odense C, Denmark

    Jørgen Vestbo

  3. Manchester Academic Health Science Centre, University Hospital South Manchester NHS Foundation Trust, The University of Manchester, Manchester, UK

    Jørgen Vestbo

  4. NIHR South Manchester Respiratory and Allergy Clinical Research Facility, Southmoor Road, Manchester, M23 9LT, UK

    Jørgen Vestbo

Authors
  1. Mia Moberg
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  2. Thomas Ringbaek
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  3. Nassim Bazeghi Roberts
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  4. Jørgen Vestbo
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Corresponding author

Correspondence to Mia Moberg.

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Moberg, M., Ringbaek, T., Roberts, N.B. et al. Association Between Vitamin D Status and COPD Phenotypes. Lung 192, 493–497 (2014). https://doi.org/10.1007/s00408-014-9582-9

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  • DOI: https://doi.org/10.1007/s00408-014-9582-9

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