European Archives of Psychiatry and Clinical Neuroscience

, Volume 264, Issue 3, pp 225–233

Brain structural imaging correlates of olfactory dysfunction in obsessive–compulsive disorder

Authors

    • OCD Clinical and Research Unit, Department of Psychiatry, Hospital de BellvitgeBellvitge University Hospital
    • Neuroscience GroupBellvitge Biomedical Research Institute-IDIBELL
    • Carlos III Health InstituteCentro de Investigación Biomédica en Red de Salud Mental (CIBERSAM)
  • Pino Alonso
    • OCD Clinical and Research Unit, Department of Psychiatry, Hospital de BellvitgeBellvitge University Hospital
    • Neuroscience GroupBellvitge Biomedical Research Institute-IDIBELL
    • Carlos III Health InstituteCentro de Investigación Biomédica en Red de Salud Mental (CIBERSAM)
    • Department of Clinical Sciences, Bellvitge CampusUniversity of Barcelona
  • Arantxa Orbegozo
    • Neuroscience GroupBellvitge Biomedical Research Institute-IDIBELL
  • Eva Real
    • OCD Clinical and Research Unit, Department of Psychiatry, Hospital de BellvitgeBellvitge University Hospital
    • Neuroscience GroupBellvitge Biomedical Research Institute-IDIBELL
    • Carlos III Health InstituteCentro de Investigación Biomédica en Red de Salud Mental (CIBERSAM)
  • Marta Subirà
    • Neuroscience GroupBellvitge Biomedical Research Institute-IDIBELL
  • Clara López-Solà
    • OCD Clinical and Research Unit, Department of Psychiatry, Hospital de BellvitgeBellvitge University Hospital
    • Neuroscience GroupBellvitge Biomedical Research Institute-IDIBELL
    • Carlos III Health InstituteCentro de Investigación Biomédica en Red de Salud Mental (CIBERSAM)
    • Department of Clinical Sciences, Bellvitge CampusUniversity of Barcelona
  • Ignacio Martínez-Zalacaín
    • Neuroscience GroupBellvitge Biomedical Research Institute-IDIBELL
  • Javier Labad
    • Hospital Psiquiàtric Universitari Institut Pere MataIISPV Universitat Rovira I Virgili
  • Ben J. Harrison
    • Department of Psychiatry, Melbourne Neuropsychiatry CentreThe University of Melbourne
  • Jesús Pujol
    • Magnetic Resonance UnitCRC-Hospital del Mar
  • José M. Menchón
    • OCD Clinical and Research Unit, Department of Psychiatry, Hospital de BellvitgeBellvitge University Hospital
    • Neuroscience GroupBellvitge Biomedical Research Institute-IDIBELL
    • Carlos III Health InstituteCentro de Investigación Biomédica en Red de Salud Mental (CIBERSAM)
    • Department of Clinical Sciences, Bellvitge CampusUniversity of Barcelona
  • Narcís Cardoner
    • Neuroscience GroupBellvitge Biomedical Research Institute-IDIBELL
    • Carlos III Health InstituteCentro de Investigación Biomédica en Red de Salud Mental (CIBERSAM)
    • Department of Clinical Sciences, Bellvitge CampusUniversity of Barcelona
  • Carles Soriano-Mas
    • Neuroscience GroupBellvitge Biomedical Research Institute-IDIBELL
    • Carlos III Health InstituteCentro de Investigación Biomédica en Red de Salud Mental (CIBERSAM)
Original Paper

DOI: 10.1007/s00406-013-0439-7

Cite this article as:
Segalàs, C., Alonso, P., Orbegozo, A. et al. Eur Arch Psychiatry Clin Neurosci (2014) 264: 225. doi:10.1007/s00406-013-0439-7

Abstract

Olfactory dysfunction has been described in obsessive–compulsive disorder (OCD). Brain regions involved in smell processing partially overlap with structures included in the neurobiological models of OCD, although no previous studies have analyzed the neuroanatomical correlates of olfactory dysfunction in this disorder. The aim of our study was to examine the association between regional gray matter volume, as assessed by a voxel-based morphometry analysis of magnetic resonance images (MRI), and olfactory function, as assessed by the Sniffin’ Sticks test (SST). Olfactory function was assessed in 19 OCD patients and 19 healthy volunteers. All participants were also scanned in a 1.5-T magnet to obtain T1-weighted anatomical MRIs, which were pre-processed and analyzed with SPM8. Three different correlation models were used to study the association between regional gray matter volumes and olfactory function in the domains assessed by the SST: detection threshold, discrimination, and identification. OCD patients showed a significant impairment in all the domains assessed by the SST. Voxel-based mapping revealed a positive association in healthy controls between detection threshold and the gray matter content of a left anterior cingulate cortex cluster. In OCD patients, a positive correlation was observed between identification errors and the gray matter volume of the left medial orbital gyrus. In a post hoc analysis, these two gray matter regions were shown to be enlarged in OCD patients. Our findings support the idea that olfactory dysfunction in OCD is associated with volumetric changes in brain areas typically implicated in the neurobiology of the disorder.

Keywords

Obsessive–compulsive disorderOlfactory functionOlfactory identificationOlfactory thresholdBrain morphometryNeuroimagingAnterior cingulate cortexMedial orbital gyrus

Copyright information

© Springer-Verlag Berlin Heidelberg 2013