Abstract
Familial Mediterranean Fever (FMF) is a progressive disease characterized by chronic inflammation, which also has negative effects on cochlear functions and hearing levels. We investigated whether the cochlear functions and hearing levels of FMF patients were different than healthy controls and also evaluated the relationship of hearing levels with the age at diagnosis, duration without treatment, and inflammation and lipid parameters in this study. A total of 60 patients diagnosed with FMF and 48 age, gender and body mass index (BMI)-matched healthy controls were included in the study. The hemogram, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and lipid parameters of the subjects were studied and they all underwent pure tone audiometry and Transient evoked otoacoustic emission tests after an otologic examination. The hearing levels of the FMF group were significantly higher than those of the control group. The TEOAE signal/noise (S/N) ratios were similar in both groups. A positive relationship was present between the audiometric test results and the age, BMI, low-density lipoprotein and triglyceride levels and a negative relationship with the high-density lipoprotein levels. A negative relationship was present between the TEOAE S/N ratios and the age of the patients, duration without treatment, lipid parameters, inflammation markers and the creatinine level. FMF patients are exposed to chronic inflammation and this can influence their hearing levels. The age at diagnosis, duration without treatment, chronic inflammation, unfavorable lipid parameters, and obesity can affect hearing tests negatively.
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References
Onen F, Sumer H, Turkay S, Akyurek O, Tunca M, Ozdogan H (2004) Increased frequency of familial Mediterranean fever in Central Anatolia, Turkey. Clin Exp Rheumatol 22:31–33
Kucuk A, Gezer IA, Ucar R, Karahan AY (2014) Familial Mediterranean Fever. Acta medica 57:97–104
Orbach H, Ben-Chetrit E (2001) Familial mediterranean fever—a review and update. Minerva Med 92:421–430
Uysal IO, Gurbuzler L, Kaya A, Koc S, Gulturk S, Cevit O, Muderris S (2012) Evaluation of cochlear function using transient evoked otoacoustic emission in children with Familial Mediterranean Fever. Int J Pediatr Otorhinolaryngol 76:379–381
Koybasi S, Atasoy HI, Bicer YO, Tug E (2012) Cochlear involvement in Familial Mediterranean Fever: a new feature of an old disease. Int J Pediatr Otorhinolaryngol 76:244–247
Thakur JS, Chauhan I, Mohindroo NK, Sharma DR, Azad RK, Vasanthalakshmi MS (2013) Otoacoustic emissions in otitis media with effusion: do they carry any clinical significance? Indian J Otolaryngol Head Neck Surg 65:29–33
Ulu Sahin, Abdulkadir Bucak M, Ulu Sena, Yilmaz Filiz, Yucedag Fatih, Ayċicek Abdullah, Solak Mustafa (2013) The relationship between arterial stiffness and cochlear functions in adult Familial Mediterranean Fever patients. Int Adv Otol 9:186–192
Rynne M, Maclean C, Bybee A, McDermott MF, Emery P (2006) Hearing improvement in a patient with variant Muckle–Wells syndrome in response to interleukin 1 receptor antagonism. Ann Rheum Dis 65:533–534
Cevik C, Silfeler I, Arica V, Yengil E, Akbay E, Sarac T, Basarslan F, Akoglu E (2013) Determination of hearing levels in patients with Familial Mediterranean Fever. Int J Pediatr Otorhinolaryngol 77:2040–2043
Keskindemirci G, Ayaz NA, Batıoğlu-Karaaltın A, Dönmez Z, Yiğit Ö, Aydoğan G, Özen S (2015) Cochlear functions in children with familial Mediterranean fever: any role of the severity of the disease? Int J Pediatr Otorhinolaryngol 79:1566–1570
Polat K, Uysal IO, Senel S, Güler C, Durmuş K, Müderris S (2013) Evaluation of hearing in patients with Familial Mediterranean Fever. Eur Arch Otorhinolaryngol 270:2871–2874
Ichimiya I, Yoshida K, Hirano T, Suzuki M, Mogi G (2000) Significance of spiral ligament fibrocytes with cochlear inflammation. Int J Pediatr Otorhinolaryngol 56:45–51
Ihler F, Strieth S, Pieri N, Göhring P, Canis M (2012). Acute hyperfibrinogenemia impairs cochlear blood flow and hearing function in guinea pigs in vivo. Int J Audiol 51:210–215
Domingos CR, Sousa RF, Becker HM, Crosara PF, Guimarães RE (2013) Ear injury as the only manifestation of amyloidosis. Braz J Otorhinolaryngol 79:119
Takumida M, Bagger-Sjöbäck D, Rask-Andersen H (1989) The endolymphatic sac and inner ear homeostasis. II: effect of glycerol on the sensory end organs with or without colchicine pretreatment. Hear Res 40:17–28
Haim G, Ephraim E, Ronen P, Haim S (2011) Colchicine prolongs patency of myringotomy in an animal model. Int J Pediatr Otorhinolaryngol 75:554–557
Jakić M, Mihaljević D, Zibar L, Jakić M, Kotromanović Z, Roguljić H (2010) Sensorineural hearing loss in hemodialysis patients. Coll Antropol 34:165–171
Kang SH, da Jung J, Choi EW, Park JW, Cho KH, Lee KY, Do JY (2015) Visceral fat area determined using bioimpedance analysis is associated with hearing loss. Int J Med Sci 12:946–951
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The study was approved by the local Ethics Committee of the University and all procedures of our study were in accordance with the revised form of the Helsinki Declaration 2013.
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Eryilmaz, M.A., Yucel, A., Cure, E. et al. The evaluation of cochlear functions in Familial Mediterranean Fever. Eur Arch Otorhinolaryngol 273, 4119–4126 (2016). https://doi.org/10.1007/s00405-016-4067-5
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DOI: https://doi.org/10.1007/s00405-016-4067-5