Abstract
Persistent rhinitis (PR) is a chronic disease that affects millions of people. However, it lacks of a useful method, which can indicate the actual severity of the inflammation in PR patients. This study was designed to seek an examination which could reflect the actual severity of PR disease. The serum Phadiatop test, ECP level, four-phase rhinomanometry, and acoustic rhinometry were assessed in 91 adult patients with PR and 10 healthy controls. The serum total IgE was determined in some of the patients and all of the controls. The patients were divided into four groups: ARWO, ARWTO, NARWO and NARWTO. 40 % (22/55) of AR and 33.3 % (13/36) of NAR patients never complained of persistent nasal obstruction. Serum ECP levels were increased in the ARWO group. Serum total IgE was significantly elevated in the AR groups. MCA1-Min and MCA1-T were significantly reduced in the ARWO, ARWTO, and NARWO groups. NV6-Min and NV6-T were decreased in all PR groups, but only some of these differences were significant. In the ARWO group, MCA2-Min (r = −0.252), MCA2-T (r = −0.377), NV6-Min (r = −0.32), and NV6-T (r = −0.311) had significant relationships with serum ECP. We recommend acoustic rhinometry as a useful routine tool for the diagnosis of PR, even among patients without persistent subjective nasal obstruction. This technique might reveal the actual status of nasal congestion. An elevated serum ECP level might indicate severe AR and is negatively correlated with the results of acoustic rhinometry.
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Acknowledgments
We thank Long Wang for performing the objective assessments, including four-phase rhinomanometry and acoustic rhinometry in this study. This work was funded by Zhejiang province health department of scientific research funds (Grant No. 2013KYB112).
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Cheng, KJ., Wang, SQ., Lin, S. et al. Objective assessment of persistent rhinitis in Chinese and its relationship with serum indicators. Eur Arch Otorhinolaryngol 272, 1679–1685 (2015). https://doi.org/10.1007/s00405-014-3241-x
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DOI: https://doi.org/10.1007/s00405-014-3241-x