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Site of infections associated with human papillomavirus

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Abstract

Introduction

Human papillomavirus (HPV) is the most clinically common sexually transmitted infection due to its carcinogenic power and the high number of lesions that it causes at different sites of the human body.

Material and methods

Genital tract organs are the most common sites where the virus can be found, but by increasing the sensitivity of diagnostic technique, it is possible to identify viral presence in different regions of the body such as the stomach, the lung, and the urinary tract. These findings break with the traditional HPV skin/genital tropic profile and demonstrate that the virus is capable of infecting a wide variety of cells, tissues, and organs or can, at least, survive in these areas. The widespread presence of the HPV in the human body, often in latent form, led us to consider the hypothesis that HPV latency may be associated with no disease.

Conclusion

This observation raises further questions about the possibility of the virus not causing disease in specific sites of the human body, but rather, behaving like a commensal/opportunistic microorganism.

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References

  1. Bernard H-U, Burk RD, Chen Z, van Doorslaer K, Hausen HZ, de Villiers E-M (2010) Classification of papillomaviruses (PVs) based on 189 PV types and proposal of taxonomic amendments. Virology 401:70–79

    CAS  PubMed Central  PubMed  Google Scholar 

  2. De Villiers E-M (2013) Cross-roads in the classification of papillomaviruses. Virology 445:2–10

    PubMed  Google Scholar 

  3. Stanley M (2001) Human papillomavirus and cervical carcinogenesis. Best Pract Res Clin Obstet Gynaecol 15:663–676

    CAS  PubMed  Google Scholar 

  4. Bzhalava D, Guan P, Franceschi S, Dillner J, Clifford G (2013) A systematic review of the prevalence of mucosal and cutaneous human papillomavirus types. Virology 445:1–8

    Google Scholar 

  5. Burkhart CG, Burkhart CN (2009) If papillomavirus found universally in epidermal tissues, what does that mean if a pcr pap test is positive ? Open Dermatol J 3:52–53

    CAS  Google Scholar 

  6. Hausen H (1976) Condylomata acuminata and human genital cancer condylomata acuminata and human genital cancer. Cancer Res 36(2 pt 2):794

    PubMed  Google Scholar 

  7. Peitsaro P, Johansson B, Syrjänen S (2002) Integrated human papillomavirus type 16 is frequently found in cervical cancer precursors as demonstrated by a novel quantitative real-time PCR technique. J Clin Microbiol 40:886–891

    CAS  PubMed Central  PubMed  Google Scholar 

  8. Zur Hausen H (2002) Papillomaviruses and cancer: from basic studies to clinical application. Nat Rev Cancer 2:342–350

    CAS  PubMed  Google Scholar 

  9. Carcopino X, Henry M, Mancini J, Giusiano S, Boubli L, Olive DTC (2012) Significance of HPV 16 and 18 viral load quantitation in women referred for colposcopy. J Med Virol 84:306–313

    PubMed  Google Scholar 

  10. Swan DC, Tucker RA, Tortolero-Luna G, Mitchell MF, Wideroff L, Unger ER, Nisenbaum RA, Reeves WC, Icenogle JP (1999) Human papillomavirus (HPV) DNA copy number is dependent on grade of cervical disease and HPV type. J Clin Microbiol 37:1030–1034

    CAS  PubMed Central  PubMed  Google Scholar 

  11. Stanley M (2010) Pathology and epidemiology of HPV infection in females. Gynecol Oncol 117(2 Suppl):S5–S10

    PubMed  Google Scholar 

  12. Zur Hausen H (2009) Papillomaviruses in the causation of human cancers: a brief historical account. Virology 384:260–265

    CAS  PubMed  Google Scholar 

  13. Oakeshott P, Beddows S, Hay PE, Reid F, Sadiq ST, Howell-Jones R, Lacey CJ, Aghaizu A, Soldan K (2012) Frequency and risk factors for prevalent, incident, and persistent genital carcinogenic human papillomavirus infection in sexually active women: community based cohort study. BMJ 344:e4168

    PubMed Central  PubMed  Google Scholar 

  14. Figueiredo Alves RR, Turchi MD, Santos LE, Guimarães EM, Garcia MM, Seixas MS, Villa LL, Costa MC, Moreira MA, De Alves M (2013) Prevalence, genotype profile and risk factors for multiple human papillomavirus cervical infection in unimmunized female adolescents in Goiania, Brazil: a community-based study. BMC Public Health 13:1041

    PubMed Central  PubMed  Google Scholar 

  15. Singh P, Oehler MK (2010) Hormone replacement after gynaecological cancer. Maturitas 65:190–197

    CAS  PubMed  Google Scholar 

  16. Franco EL, Duarte-franco E, Ferenczy A (2001) Cervical cancer: epidemiology, prevention and the role of human papillomavirus infection. CMAJ 164:1017–1025

    CAS  PubMed Central  PubMed  Google Scholar 

  17. Ripabelli G, Grasso GM, Del Riccio I, Tamburro M, Sammarco ML (2010) Prevalence and genotype identification of human papillomavirus in women undergoing voluntary cervical cancer screening in Molise, central Italy. Cancer Epidemiol 34:162–167

    PubMed  Google Scholar 

  18. Rahkola-Soisalo P, Mikkola TS, Vuorento S, Ylikorkala O, Väisänen-Tommiska M (2013) Smoking is accompanied by a suppressed cervical nitric oxide release in women with high-risk human papillomavirus infection. Acta Obstet Gynecol Scand 92:711–715

    PubMed  Google Scholar 

  19. Brotherton JM (2014) Human papillomavirus vaccination: where are we now? J Paediatr Child Health. doi:10.1111/jpc.12627

  20. Joura EA, Garland SM, Paavonen J, Ferris DG, Perez G, Ault KA, Huh WK, Sings HL, James MK, Haupt RM (2012) Effect of the human papillomavirus (HPV) quadrivalent vaccine in a subgroup of women with cervical and vulvar disease: retrospective pooled analysis of trial data. BMJ 344:e1401

    PubMed Central  PubMed  Google Scholar 

  21. Barroso LF (2013) The role of human papilloma virus (HPV) vaccination in the prevention of anal cancer in individuals with human immunodeficiency virus-1 (HIV-1) infection. Ther Adv vaccines 1:81–92

    PubMed Central  PubMed  Google Scholar 

  22. Wierzbicka M, Józefiak A, Jackowska J, Szydłowski J, Goździcka-Józefiak A (2014) HPV vaccination in head and neck HPV-related pathologies. Otolaryngol Pol 68:157–173

    PubMed  Google Scholar 

  23. Bosch FX, Broker TR, Forman D, Moscicki A-B, Gillison ML, Doorbar J, Stern PL, Stanley M, Arbyn M, Poljak M, Cuzick J, Castle PE, Schiller JT, Markowitz LE, Fisher WA, Canfell K, Denny LA, Franco EL, Steben M, Kane MA, Schiffman M, Meijer CJLM, Sankaranarayanan R, Castellsagué X, Kim JJ, Brotons M, Alemany L, Albero G, Diaz M, de Sanjosé S (2013) Comprehensive control of human papillomavirus infections and related diseases. Vaccine 31(Suppl 8):I1–I31

    PubMed Central  PubMed  Google Scholar 

  24. Burger EA, Sy S, Nygård M, Kristiansen IS, Kim JJ (2014) Prevention of HPV-related cancers in norway: cost-effectiveness of expanding the hpv vaccination program to include pre-adolescent boys. PLoS One 9:e89974

    PubMed Central  PubMed  Google Scholar 

  25. Schwarz E, Freese UK, Gissmann L, Mayer W, Roggenbuck B, Stremlau A, ZurHausen H (1985) Structure and transcription of human papillomavirus sequences in cervical carcinoma cells. Nature 314:111–114

    CAS  PubMed  Google Scholar 

  26. Nindl I, Rindfleisch K, Lotz B, Schneider A, Dürst M (1999) Uniform distribution of HPV 16 E6 and E7 variants in patients with normal histology, cervical intra-epithelial neoplasia and cervical cancer. Int J Cancer 82:203–207

    CAS  PubMed  Google Scholar 

  27. Daling JR, Madeleine MM, Schwartz SM, Shera KA, Carter JJ, McKnight B, Porter PL, Galloway DA, McDougall JK, Tamimi H (2002) A population-based study of squamous cell vaginal cancer: HPV and cofactors. Gynecol Oncol 84:263–270

    CAS  PubMed  Google Scholar 

  28. Chaturvedi AK (2010) Beyond cervical cancer: burden of other HPV-related cancers among men and women. J Adolesc Health 46(4 Suppl):S20–S26

    PubMed  Google Scholar 

  29. Medeiros do Amaral CM, Freitas AC, Crovella S, Silva MAR, Guimarães V, Stocco RC, Beçak W, da Silva Baldez MFPT (2012) Frequency of human papillomavirus types 16, 18, 31, and 33 and sites of cervical lesions in gynecological patients from Recife, Brazil. Genet Mol Res 11:462–466

    PubMed  Google Scholar 

  30. Sugase M, Matsukura T (1997) Distinct manifestations of human papillomaviruses in the vagina. Int J Cancer 72:412–415

    CAS  PubMed  Google Scholar 

  31. Shew ML, Weaver B, Tu W, Tong Y, Fortenberry JD, Brown DR (2013) High frequency of human papillomavirus detection in the vagina before first vaginal intercourse among females enrolled in a longitudinal cohort study. J Infect Dis 207:1–4

    Google Scholar 

  32. Horn L-C, Klostermann K, Hautmann S, Höhn AK, Beckmann MW, Mehlhorn G (2011) HPV-associated alterations of the vulva and vagina. Pathologe 32(6):467–475

  33. Sinno AK, Saraiya M, Thompson TD, Hernandez BY, Goodman MT, Steinau M, Lynch CF, Cozen W, Saber MS, Peters ES, Wilkinson EJ, Copeland G, Hopenhayn C, Watson M, Lyu C, Unger ER (2014) Human papillomavirus genotype prevalence in invasive vaginal cancer from a registry-based population. Obstet Gynecol 123:817–821

    PubMed  Google Scholar 

  34. Stroup AM, Harlan LC, Trimble EL (2008) Demographic, clinical, and treatment trends among women diagnosed with vulvar cancer in the United States. Gynecol Oncol 108:577–583

    CAS  PubMed  Google Scholar 

  35. Schuurman, van den Einden LCG, Massuger LFAG, Kiemeney LA, van der Aa MA, de Hullu JA (2013) Trends in incidence and survival of Dutch women with vulvar squamous cell carcinoma. Eur J Cancer 49:3872–3880

    CAS  PubMed  Google Scholar 

  36. Del Pino M, Rodriguez-Carunchio L, Ordi J (2013) Pathways of vulvar intraepithelial neoplasia and squamous cell carcinoma. Histopathology 62:161–175

    PubMed  Google Scholar 

  37. Maniar KP, Ronnett BM, Vang R, Yemelyanova A (2012) Coexisting High-grade Vulvar Intraepithelial Neoplasia (VIN) and Condyloma Acuminatum. Am J Surg Pathol 37(1):53–60

  38. Hampl M, Deckers-Figiel S, Hampl JA, Rein D, Bender HG (2008) New aspects of vulvar cancer: changes in localization and age of onset. Gynecol Oncol 109:340–345

    PubMed  Google Scholar 

  39. Zhou J, Xiao S, Deng X, Cui C (2013) Expression of HPV16 E6 protein in nonneoplastic epithelial disorder of the vulva and squamous cell carcinoma of the vulva. Zhong Nan Da Xue Xue Bao Yi Xue Ban 38:225–230

    CAS  PubMed  Google Scholar 

  40. Preti M, Scurry J, Marchitelli CE (2014) Vulvar intraepithelial neoplasia. Best Pr Res Clin Obs Gynaecol S1521–6934:134–135

    Google Scholar 

  41. Ferlay J, Soerjomataram I, Ervik M, Dikshit R, Eser S, Mathers C, Rebelo M PD, Forman D, Bray F (2013) GLOBOCAN 2012 v1.0, Cancer Incidence and Mortality Worldwide: IARC CancerBase. No. 11 [Internet]. Lyon, Fr Int Agency Res Cancer. http://globocan.iarc.f

  42. Anttila M, Syrjänen S, Ji H, Saarikoski S, Syrjänen K (1999) Failure to demonstrate human papillomavirus DNA in epithelial ovarian cancer by general primer PCR. Gynecol Oncol 72:337–341

    CAS  PubMed  Google Scholar 

  43. Wu Q-J, Guo M, Lu Z-M, Li T, Qiao H-Z, Ke Y (2003) Detection of human papillomavirus-16 in ovarian malignancy. Br J Cancer 89:672–675

    PubMed Central  PubMed  Google Scholar 

  44. Lai C-H, Wang C-Y, Lin C-Y (1994) No detection of human papillomavirus rna in ovarian and endometrial carcinomas by reverse transcription/polymerase chain reaction. Gynecol Obs Invest 38:276–280

    CAS  Google Scholar 

  45. Manolitsas TP, Lanham SA, Hitchcock A, Watson RH (1998) Synchronous ovarian and cervical squamous intraepithelial neoplasia: an analysis of HPV status. Gynecol Oncol 70:428–431

    CAS  PubMed  Google Scholar 

  46. Svahn MF, Faber MT, Christensen J, Norrild B, Kjaer SK (2013) Prevalence of human papillomavirus in epithelial ovarian cancer tissue. A meta-analysis of observational studies. Acta Obstet Gynecol Scand 93:6–19

    PubMed  Google Scholar 

  47. GLOBOCAN (2012) Estimated Cancer Incidence, Mortality and Prevalence Worldwide in 2012. http://globocan.iarc.fr/Pages/fact_sheets_cancer.aspx

  48. Ha PK, Califano JA (2004) The role of human papillomavirus in oral carcinogenesis. Crit Rev Oral Biol Med 15:188–196

    PubMed  Google Scholar 

  49. Cândido AC, de Lima Filho JL, Martins DB, Mendes CM, Vieira JR (2013) Association of human papillomavirus genomic sequences by polymerase chain reaction in gastric carcinomas in Brazil. Anal Quant Cytol Histol 35:1–6

    Google Scholar 

  50. Beniston RG, Campo MS (2003) Quercetin elevates p27(Kip1) and arrests both primary and HPV16 E6/E7 transformed human keratinocytes in G1. Oncogene 22:5504–5514

    CAS  PubMed  Google Scholar 

  51. dos Santos Stocco RC, Lindsey CJ, Ferraz OP, Pinto JR, Mirandola RS, Benesi FJ, Birgel EH, Pereira CA, Beçak W (1998) Bovine papillomavirus transmission and chromosomal aberrations: an experimental model. J Gen Virol 79(Pt 9):2127–2135

    Google Scholar 

  52. Xu WG, Zhang LJ, Lu ZM, Li JY, Ke YXG (2003) Detection of human papillomavirus type 16 E6 mRNA in carcinomas of upper digestive tract. Zhonghua Yi Xue Za Zhi 83:1910–1914

    CAS  PubMed  Google Scholar 

  53. Snietura M, Waniczek D, Piglowski W, Kopec A, Nowakowska-Zajdel E, Lorenc Z, Muc-Wierzgon M (2014) Potential role of human papilloma virus in the pathogenesis of gastric cancer. World J Gastroenterol 20:6632–6637

    PubMed Central  PubMed  Google Scholar 

  54. Mavrogianni P, Alexandrakis G, Stefanaki C, Hadzivassiliou M, Karameris A, Mela A, Bethimoutis G, Apostolopoulos P, Tsibouris P, Katsambas A, Kalantzis N (2011) The role of cytology and HPV typing as a screening tool in patients with intraanal warts. J Clin Gastroenterol 45:e39–e43

    PubMed  Google Scholar 

  55. Castor MDGFC, Da Silva HJ, Gondim Martins DB, Vieira De Mello RJ (2012) HPV and precancerous lesions of anal canal in women: systematic review. Int J Colorectal Dis 27(3):271–276

  56. Hu Y, Qian HZ, Sun J, Gao L, Yin L, Li X, Xiao D, Li D, Sun X, Ruan Y, Milam DF, Pan SW, Shao Y, Vermund SH (2013) Anal human papillomavirus infection among HIV-infected and uninfected men who have sex with men in Beijing, China. J Acquir Immune Defic Syndr 64:103–114

    PubMed Central  PubMed  Google Scholar 

  57. Darwich L, Cañadas M, Videla S, Coll J, Piñol M, Cobarsi P, Molina-López R, Vela S, García-Cuyás F, Llatjos M, Sirera G, Clotet B (2012) Condylomata, cytological abnormalities and human papillomavirus infection in the anal canal in HIV-infected men. HIV Med 13:549–557

    CAS  PubMed  Google Scholar 

  58. Koppe DC, Bandeira CB, Rosa MRD, Cambruzzi E, Meurer L, Fagundes RB (2011) Prevalence of anal intraepithelial neoplasia in women with genital neoplasia. Dis Colon Rectum 54:442–445

    PubMed  Google Scholar 

  59. Edgren G, Sparén P (2007) Risk of anogenital cancer after diagnosis of cervical intraepithelial neoplasia: a prospective population-based study. Lancet Oncol 8:311–316

    PubMed  Google Scholar 

  60. Jacyntho CMA, Giraldo PC, Horta AA, Grandelle R, Gonalves AK, Fonseca T, Eleutério J (2011) Association between genital intraepithelial lesions and anal squamous intraepithelial lesions in HIV-negative women. Am J Obstet Gynecol 205(2):115.e1–115.e5

  61. Tatti S, Suzuki V, Fleider L, Maldonado V, Caruso R, Tinnirello M, de los A (2012) Anal intraepithelial lesions in women with human papillomavirus–related disease. J Low Genit Tract Dis 16(4):454–459

  62. Scholefield JH, Hickson WGE, Smith JHF, Rogers K, Sharp F (1992) Anal intraepithelial neoplasia: part of a multifocal disease process. Lancet 340:1271–1273

    CAS  PubMed  Google Scholar 

  63. Salit IE, Tinmouth J, Chong S, Raboud J, Diong C, Su D, Sano M, Lytwyn A, Chapman W, Mahony J (2009) Screening for HIV-associated anal cancer: correlation of HPV genotypes, p16, and E6 transcripts with anal pathology. Cancer Epidemiol Biomarkers Prev 18:1986–1992

    CAS  PubMed  Google Scholar 

  64. Schwartz LM, Castle PE, Follansbee S, Borgonovo S, Fetterman B, Tokugawa D, Lorey TS, Sahasrabuddhe VV, Luhn P, Gage JC, Darragh TM, Wentzensen N (2013) Risk factors for anal HPV infection and anal precancer in hiv-infected men who have sex with men. J Infect Dis 208:1768–1775

    CAS  PubMed Central  PubMed  Google Scholar 

  65. Machalek DA, Poynten M, Jin F, Fairley CK, Farnsworth A, Garland SM, Hillman RJ, Petoumenos K, Roberts J, Tabrizi SN, Templeton DJ, Grulich AE (2012) Anal human papillomavirus infection and associated neoplastic lesions in men who have sex with men: a systematic review and meta-analysis. Lancet Oncol 13:487–500

    PubMed  Google Scholar 

  66. Park IU, Ogilvie JW, Anderson KE, Li ZZ, Darrah L, Madoff R, Downs L (2009) Anal human papillomavirus infection and abnormal anal cytology in women with genital neoplasia. Gynecol Oncol 114:399–403

    PubMed  Google Scholar 

  67. Stanley M, Winder D, Sterling J, Goon P (2012) HPV infection, anal intra-epithelial neoplasia (AIN) and anal cancer: current issues. BMC Cancer 12:398

    PubMed Central  PubMed  Google Scholar 

  68. Nathan M, Singh N, Garrett N, Hickey N, Prevost T, Sheaff M (2010) Performance of anal cytology in a clinical setting when measured against histology and high-resolution anoscopy findings. AIDS 24:373–379

    PubMed  Google Scholar 

  69. Tong WW, Jin F, McHugh LC, Maher T, Sinclair B, Grulich AE, Hillman RJ, Carr A (2013) Progression to and spontaneous regression of high-grade anal squamous intraepithelial lesions in HIV-infected and uninfected men. AIDS 27:2233–2243

    PubMed  Google Scholar 

  70. Selvaggi SM (2014) Anal-rectal cytology as a screening tool for the detection of anal intraepithelial neoplasia in HIV-positive men. J Am Soc Cytopathol 3:151–155

    Google Scholar 

  71. D’Hauwers KWM, Cornelissen T, Depuydt CE, Bogers J, Donders ART, Leuridan E, Van Damme P, Tjalma WAA (2012) Anal human papillomavirus DNA in women at a colposcopy clinic. Eur J Obstet Gynecol Reprod Biol 164:69–73

    PubMed  Google Scholar 

  72. Baandrup L, Thomsen LT, Olesen TB, Andersen KK, Norrild B, Kjaer SK (2014) The prevalence of human papillomavirus in colorectal adenomas and adenocarcinomas: A systematic review and meta-analysis. Eur J Cancer 50(8):1446–1461

  73. Damin DC, Ziegelmann PK (2013) Damin a P: Human papillomavirus infection and colorectal cancer risk: a meta-analysis. Colorectal Dis 15:e420–e428

    CAS  PubMed  Google Scholar 

  74. Panagiotakis GI, Papadogianni D, Chatziioannou MN, Lasithiotaki I, Delakas DSD (2013) Association of human herpes, papilloma and polyoma virus families with bladder cancer. Tumor Biol 34:71–79

    CAS  Google Scholar 

  75. Li N, Yang L, Zhang Y, Zhao P, Zheng T, Dai M (2011) Human papillomavirus infection and bladder cancer risk: a meta-analysis. J Infect Dis 204:217–223

    PubMed Central  PubMed  Google Scholar 

  76. Blochin EB, Park KJ, Tickoo SK, Reuter VEA-AH (2012) Urothelial carcinoma with prominent squamous differentiation in the setting of neurogenic bladder: role of human papillomavirus infection. Mod Pathol 25:1534–1542

    PubMed  Google Scholar 

  77. Kamel D, Pääkkö P, Pöllänen R, Vähäkangas K, Lehto VP (1995) Human papillomavirus DNA and abnormal p53 expression in carcinoma of the urinary bladder. APMIS 103:331–338

    CAS  PubMed  Google Scholar 

  78. Alexander RE, Williamson SR, Richey J, Lopez-Beltran A, Montironi R, Davidson DD, Idrees MT, Jones CL, Zhang S, Wang L, Rao Q, Pedrosa JA, Kaimakliotis HZ, Monn MF, Koch MO, Cheng L (2014) The expression patterns of p53 and p16 and an analysis of a possible role of HPV in primary adenocarcinoma of the urinary bladder. PLoS ONE 9:e95724

    PubMed Central  PubMed  Google Scholar 

  79. Shaker OG, Hammam OA, Wishahi MM (2013) Is there a correlation between HPV and urinary bladder carcinoma? Biomed Pharmacother 67:183–191

    PubMed  Google Scholar 

  80. Fonseca AG, Soares FA, Burbano RR, Silvestre RVPL (2013) Human papilloma virus: prevalence, distribution and predictive value to lymphatic metastasis in penile carcinoma. Int Braz J Urol 39:542–550

    PubMed  Google Scholar 

  81. Walczak L, Dutkiewicz S (2013) Incidence and prevalence of multiple types of genital human papillomavirus (HPV) infection in men: a study in Poland. Ginekol Pol 84:112–115

    PubMed  Google Scholar 

  82. Darwich L, Cañadas M-P, Videla S, Coll J, Molina-López RA, Sirera G, Clotet B (2013) Prevalence, clearance, and incidence of human papillomavirus type-specific infection at the anal and penile site of HIV-infected men. Sex Transm Dis 40:611–618

    PubMed  Google Scholar 

  83. Sichero L, Pierce Campbell CM, Ferreira S, Sobrinho JS, Luiza Baggio M, Galan L, Silva RC, Lazcano-Ponce E, Giuliano AR, Villa LL (2013) Broad HPV distribution in the genital region of men from the HPV infection in men (HIM) study. Virology 443:214–217

    CAS  PubMed Central  PubMed  Google Scholar 

  84. Garolla A, Pizzol D, Foresta C (2011) The role of human papillomavirus on sperm function. Curr Opin Obstet Gynecol 23:232–237

    PubMed  Google Scholar 

  85. Tachezy R, Hrbacek J, Heracek J, Salakova M, Smahelova J, Ludvikova V, Svec A, Urban M, Hamsikova E (2012) HPV persistence and its oncogenic role in prostate tumors. J Med Virol 1645(June):1636–1645

    Google Scholar 

  86. Ghasemian E, Monavari SH, Irajian GR, Jalali Nodoshan MR, Roudsari RV (2013) Evaluation of human papillomavirus infections in prostatic disease: a cross-sectional study in Iran. Asian Pac J Cancer Prev 14:3305–3308

    PubMed  Google Scholar 

  87. Serth J, Panitz F, Paeslack U (1999) Increased levels of human papillomavirus type 16 DNA in a subset of prostate cancers. Cancer Res 59:823–825

    CAS  PubMed  Google Scholar 

  88. Chuang AY, Chuang TC, Chang S, Zhou S, Begum S, Westra WH, Ha PK, Koch WM, Califano JA (2008) Presence of HPV DNA in convalescent salivary rinses is an adverse prognostic marker in head and neck squamous cell carcinoma. Oral Oncol 44:915–919

    CAS  PubMed Central  PubMed  Google Scholar 

  89. Haddad R, Crum C, Chen Z, Krane J, Posner M, Li Y, Burk R (2008) HPV16 transmission between a couple with HPV-related head and neck cancer. Oral Oncol 44:812–815

    PubMed  Google Scholar 

  90. Adamopoulou M, Vairaktaris E, Nkenke E, Avgoustidis D, Karakitsos P, Sioulas V, Nisyrios T, Yapijakis C (2013) Gynecologic oncology prevalence of human papillomavirus in saliva and cervix of sexually active women. Gynecol Oncol 129:395–400

    PubMed  Google Scholar 

  91. Gonçalves AK, Giraldo P, Barros-Mazon S, Gondo ML, Amaral RLJC (2006) Secretory immunoglobulin A in saliva of women with oral and genital HPV infection. Eur J Obs Gynecol Reprod Biol 124:227–231

    Google Scholar 

  92. Pransky SM, Magit AE, Kearns DB, Kang DRDN (1999) Intralesional cidofovir for recurrent respiratory papillomatosis in children. Arch Otolaryngol Head Neck Surg 125:1143–1148

    CAS  PubMed  Google Scholar 

  93. Rice PS, Mant C, Cason J, Bible JM, Muir P, Kell B, Best JM (2000) High prevalence of human papillomavirus type 16 infection among children. J Med Virol 61:70–75

    CAS  PubMed  Google Scholar 

  94. Krane JF (2013) Role of cytology in the diagnosis and management of HPV-associated head and neck carcinoma. Acta Cytol 57:117–126

    PubMed  Google Scholar 

  95. Kovalenko S, Lukashenko P, Romanovskaya A, Soldatski IL, Bakanov SI, Pfister H, Gerein V (2009) Distribution and density of CD1a+ and CD83+ dendritic cells in HPV-associated laryngeal papillomas. Int J Pediatr Otorhinolaryngol 73:249–256

    PubMed  Google Scholar 

  96. Nichols AC, Faquin WC, Westra WH, Mroz EA, Begum S, Clark JR (2009) Head and neck surgery HPV-16 infection predicts treatment outcome in oropharyngeal squamous cell carcinoma. YMHN 140:228–234

    Google Scholar 

  97. Holmes BJ, Westra WH (2014) The expanding role of cytopathology in the diagnosis of HPV-related squamous cell carcinoma of the head and neck. Diagn Cytopathol 42(1):85–93

  98. Rydzewski B, Goździcka-Józefiak A, Sokalski J, Matusiak M, Durzyński L (2007) Identification of human papilloma viruses (HPV) in inflammatory states and ear neoplasms. Otolaryngol Pol 61:137–141

    PubMed  Google Scholar 

  99. Chao WY, Chang SJ, Jin YT (2000) Detection of human papillomavirus in cholesteatomas. Eur Arch Otorhinolaryngol 257:120–123

    CAS  PubMed  Google Scholar 

  100. Stremlau A, Helms J, Müller-Hermelink HK, Hoppe F, de Villiers EM (1995) Detection of DNA of human papillomaviruses (HPV) in an “aggressively” growing cholesteatoma. Is cholesteatoma a virus-induced tumor? HNO 43:3–5

    CAS  PubMed  Google Scholar 

  101. Donne AJ, Hampson L, Homer JJ, Hampson IN (2010) The role of HPV type in recurrent respiratory papillomatosis. Int J Pediatr Otorhinolaryngol 74:7–14

    CAS  PubMed  Google Scholar 

  102. Klein F, Amin WFM, Petersen I (2009) Incidence of human papilloma virus in lung cancer. Lung Cancer 65:13–18

    PubMed  Google Scholar 

  103. Wang J, Fang C, Wang M, Yu M, Bai K, Lu P, Liu HE (2014) Human papillomavirus infections as a marker to predict overall survival in lung adenocarcinoma. Int J Cancer 134:65–71

    PubMed  Google Scholar 

  104. Bolboaca SD, Chirila M (2014) Clinical efficiency of quadrivalent HPV (types 6/11/16/18) vaccine in patients with recurrent respiratory papillomatosis. Eur Arch Otorhinolaryngol 271(5):1135–1142

  105. Lorenzon L, Benevolo M, Visca P, Venturo I, Filippetti M, Piro FR, Rollo F, Vocaturo A (2012) Human papillomavirus type 16 DNA detected in pulmonary metastases from a penile squamous cell carcinoma: a case study. Int J Surg Pathol 21(1):59–62

  106. Roth R, Moffatt-Bruce S, Leon ME (2014) Metastatic squamous cell carcinoma of the anus to the lung confirmed with allelotyping. Case Rep Pathol 2014:608521

    PubMed Central  PubMed  Google Scholar 

  107. Montoya-Fuentes H, de la Paz Ramirez-Munoz M, Villar-Calvo V, Suarez-Rincon AE, Ornelas-Aguirre JM, Vazquez-Camacho G, Orbach-Arbouys S, Bravo-Cuellar AS (2003) Identification of DNA sequences and viral proteins of 6 human papillomavirus types in retinoblastoma tissue. Anticancer Res 23:2853–2862

    CAS  PubMed  Google Scholar 

  108. Shetty OA, Naresh KN, Path FRC, Banavali SD, Shet T, Joshi R, Qureshi S, Mulherkar R, Borges A, Desai SB (2012) Evidence for the presence of high risk human papillomavirus in retinoblastoma tissue from nonfamilial retinoblastoma in developing countries. Pediatr Blood Cancer 58:185–190

    PubMed  Google Scholar 

  109. Pablo J, Espinoza M, Judith V, Cardenas P, Aguilar C, Montoya H, Vazquez G, Mendoza F, Ramon J, Garcia G (2005) Loss of 10p material in a child with human papillomavirus—positive disseminated bilateral retinoblastoma. Cancer Genet Cytogenet 161:146–150

    Google Scholar 

  110. Hsu CR, Lu TM, Chin LWYC (2010) Possible DNA viral factors of human breast cancer. Cancers (Basel) 2:498–512

    CAS  Google Scholar 

  111. Sigaroodi A, Nadji SA, Naghshvar F, Nategh R, Emami H, Velayati AA: Human papillomavirus is associated with breast cancer in the north part of Iran. Sci World J 2012:837191

  112. Herrera-goepfert R, Vela-chávez T, Carrillo-garcía A, Lizano-soberón M, Amador-molina A, Oñate-ocaña LF, Hallmann RS (2013) High-risk human papillomavirus (HPV) DNA sequences in metaplastic breast carcinomas of Mexican women. BMC Cancer 13:445

    PubMed Central  PubMed  Google Scholar 

  113. Wu M, Chan JY, Liu P, Liu S, Huang S (2007) Human papillomavirus E2 protein associates with nuclear receptors to stimulate nuclear receptor- and E2-dependent transcriptional activations in human cervical carcinoma cells. Int J Biochem Cell Biol 39:413–425

    CAS  PubMed  Google Scholar 

  114. Cazzaniga M, Gheit T, Casadio C, Khan N, Macis D, Valenti F, Miller MJ, Sylla BS, Akiba S, Bonanni B, Decensi A, Veronesi U (2009) Analysis of the presence of cutaneous and mucosal papillomavirus types in ductal lavage fluid, milk and colostrum to evaluate its role in breast carcinogenesis. Breast Cancer Res Treat 114:599–605

    PubMed  Google Scholar 

  115. Mendizabal-Ruiz AP, Morales JA, Ramírez-Jirano LJ, Padilla-Rosas M, Morán-Moguel MCM-FH (2009) Low frequency of human papillomavirus DNA in breast cancer tissue. Breast Cancer Res Treat 114:189–194

    CAS  PubMed  Google Scholar 

  116. Sterling JC (2001) Guidelines for the management of cutaneous warts. Br J Dermatol 144:4–11

    CAS  PubMed  Google Scholar 

  117. Köhler A, Gottschling M, Förster J, Röwert-Huber J, Stockfleth E, Nindl I (2010) Genomic characterization of a novel human papillomavirus (HPV-117) with a high viral load in a persisting wart. Virology 399:129–133

    PubMed  Google Scholar 

  118. Al Bdour S, Akkash L, Shehabi AA (2013) Detection and typing of common human papillomaviruses among jordanian patients. J Med Virol 85:1058–1062

    CAS  PubMed  Google Scholar 

  119. Giannaki M, Kakourou T, Theodoridou M, Syriopoulou V, Kabouris M, Louizou E (2013) Human papillomavirus (HPV) genotyping of cutaneous warts in greek children. Pediatr Dermatol 30:730–735

    PubMed  Google Scholar 

  120. Ekström J, Sara L, Mühr A, Bzhalava D, Söderlund-strand A, Hultin E, Nordin P, Stenquist B, Paoli J, Forslund O, Dillner J (2013) Diversity of human papillomaviruses in skin lesions. Virology 447:300–311

    PubMed  Google Scholar 

  121. Hsiao Y, Yang J, Wu W, Lin M, Sheu G (2013) E6 and E7 of human papillomavirus type 18 and UVB irradiation corporately regulate interleukin-6 and interleukin-8 expressions in basal cell carcinoma. Exp Dermatol 22:672–674

    CAS  PubMed  Google Scholar 

  122. Zahir A, Craig L, Rady P, Tyring S, Ehrlich A (2013) Epidermodysplasia verruciformis associated with HPV 10. Dermatol Online J 19:2

    PubMed  Google Scholar 

  123. Gnanamony M, Peedicayil A, Subhashini J, Ram TS, Rajasekar A, Gravitt P, Abraham P (2010) Detection and quantitation of HPV 16 and 18 in plasma of Indian women with cervical cancer. Gynecol Oncol 116:447–451

    CAS  PubMed  Google Scholar 

  124. Chan PKS, Yu MMY, Cheung T-H, To K-F, Lo KWK, Cheung JLK, Tong JHM (2005) Detection and quantitation of human papillomavirus DNA in primary tumour and lymph nodes of patients with early stage cervical carcinoma. J Clin Virol 33:201–205

    CAS  PubMed  Google Scholar 

  125. Capone RB, Pai SI, Koch WM, Gillison ML, Danish HN, Westra WH, Daniel R, Shah KVSD (2000) Detection and quantitation of human papillomavirus (HPV) DNA in the sera of patients with HPV-associated head and neck squamous cell carcinoma. Clin Cancer Res 6:4171–4175

    CAS  PubMed  Google Scholar 

  126. Sathish N, Abraham P, Peedicayil A, Sridharan G, John S, Shaji RV, Chandy G (2004) HPV DNA in plasma of patients with cervical carcinoma. J Clin Virol 31:204–209

    CAS  PubMed  Google Scholar 

  127. Bodaghi S, Wood LV, Roby G, Ryder C, Steinberg SM (2005) Could human papillomaviruses be spread through blood? J Clin Microbiol 43:5428–5434

    PubMed Central  PubMed  Google Scholar 

  128. Sonnex C, Strauss S, Gray JJ (1999) Detection of human papillomavirus DNA on the fingers of patients with genital warts. Sex Transm Infect 75:317–319

    CAS  PubMed Central  PubMed  Google Scholar 

  129. Boxman IL, Hogewoning A, Mulder LH, Bavinck JNB, ter Schegget J (1999) Detection of human papillomavirus types 6 and 11 in pubic and perianal hair from patients with genital warts. J Clin Microbiol 37:2270–2273

    CAS  PubMed Central  PubMed  Google Scholar 

  130. Schneider I, Lehmann MD, Kogosov V, Stockfleth E, Nindl I (2013) Eyebrow hairs from actinic keratosis patients harbor the highest number of cutaneous human papillomaviruses. BMC Infect Dis 13:186

    PubMed Central  PubMed  Google Scholar 

  131. García-de Marcos JA, Pérez-Zafrilla B, Arriaga A, Arroyo-Rodríguez SPE (2014) Human papillomavirus in carcinomas of the tongue: clinical and prognostic implications. Int J Oral Maxillofac Surg 43:274–280

    PubMed  Google Scholar 

  132. Salehipoor M, Khezri A, Behzad-Behbahani A, Geramizadeh B, Rahsaz M, Aghdaei M (2012) Role of viruses in renal cell carcinoma. Saudi J Kidney Dis Transpl 23:53–57

    PubMed  Google Scholar 

  133. Tong TR, Chan A, Lai T, Chan OW, Lee K, Lo STH, Lung R, Li JYW, Chow T (2007) Identification of HPV-16 in borderline mucinous cystic neoplasm of pancreas. Int J Biomed Sci 3:72–75

    PubMed Central  PubMed  Google Scholar 

  134. Shukla S, Bharti AC, Mahata S, Hussain S, Kumar R, Hedau S, Das BC (2009) Infection of human papillomaviruses in cancers of different human organ sites. Indian J Med Res 130:222–233

    CAS  PubMed  Google Scholar 

  135. SPG (2007) Sociedade Portuguesa de Ginecologia, Vacina contra o HPV. Reunião de Consenso Nacional:6–7

  136. Kerkar SC, Latta S, Salvi V, Mania-Pramanik J (2011) Human Papillomavirus infection in asymptomatic population. Sex Reprod Healthc 2:7–11

    PubMed  Google Scholar 

  137. Powell J, Strauss S, Gray J, Path PDMRC, Wojnarowska F (2003) Genital carriage of human papilloma virus (HPV) DNA in prepubertal girls with and without vulval disease. Pediatr Dermatol 20:191–194

    PubMed  Google Scholar 

  138. Clifford G, Franceschi S, Diaz M, Muñoz N, Villa LL (2006) HPV type-distribution in women with and without cervical neoplastic diseases. Vaccine 24(Suppl 3):S26–S34

    Google Scholar 

  139. Barton ES, White DW, Cathelyn JS, Brett-mcclellan KA, Engle M, Diamond MS, Miller VL, Iv HWV (2007) Herpesvirus latency confers symbiotic protection from bacterial infection. Nature 447:326–329

    CAS  PubMed  Google Scholar 

  140. Backes DM, Kurman RJ, Pimenta JM, Smith JS (2009) Systematic review of human papillomavirus prevalence in invasive penile cancer. Cancer Causes Control 20:449–457

    PubMed  Google Scholar 

  141. Guan P, Clifford GM, Franceschi S (2013) Human papillomavirus types in glandular lesions of the cervix: a meta-analysis of published studies. Int J Cancer 132:248–250

    CAS  PubMed  Google Scholar 

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Acknowledgments

The authors thank Dr. Albert Leyva for grammatical corrections of this review.

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We declare that we have no conflict of interest.

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Authors and Affiliations

  1. Laboratory of Imunopathology Keizo Asami (LIKA), Federal University of Pernambuco (UFPE), Av. Prof. Moraes Rego, 1235 Cidade Universitária, Recife, PE, CEP 50670-901, Brazil

    Monique Beltrão, Marcela Silvestre Outtes Wanderley, Nataly Amorim de Santana, Danyelly Bruneska & José Luiz de Lima Filho

  2. Biochemistry Department, Federal University of Pernambuco (UFPE), Recife, Pernambuco, Brazil

    Danyelly Bruneska & José Luiz de Lima Filho

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  1. Monique Beltrão
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  2. Marcela Silvestre Outtes Wanderley
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Correspondence to Monique Beltrão.

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Beltrão, M., Wanderley, M.S.O., de Santana, N.A. et al. Site of infections associated with human papillomavirus. Arch Gynecol Obstet 291, 481–491 (2015). https://doi.org/10.1007/s00404-014-3480-5

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