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Clinical management of cervical intraepithelial neoplasia in pregnant and postpartum women

  • Gynecologic Oncology
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Objective

To evaluate the clinical management of cervical intraepithelial neoplasia (CIN) and cervical microinvasive squamous cell carcinoma in pregnant and postpartum women.

Methods

This prospective study enrolled 27,230 pregnant women undergoing routine gestational examinations between August 1, 2007 and July 31, 2010 in the Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Colposcopy and cervical biopsy were performed for patients with abnormal Thin Prep® Papanicolaou test (TCT) results. Periodic colposcopy was performed every 8–12 weeks and cervical biopsy was performed if progression was suspected. Cervical cold knife conization was recommended to patients diagnosed with CINIII or microinvasive cervical carcinoma 6–12 weeks after delivery.

Results

A total of 2,260 patients had abnormal TCT results (8.12 %). Colposcopy and cervical biopsy were performed for 369 patients. Fifteen patients had microinvasive squamous cell carcinoma, 116 patients had cervicitis, and the number of CIN patients with histological grades I, II, and III were 124, 49, and 65, respectively. Tumor progression during pregnancy was found in 253 patients (CINI or above). Prognosis varied depending on the highest grade of pathological diagnosis results during pregnancy or initial pathological diagnosis results performed 6–12 weeks after delivery by cervical biopsy under colposcopy. Treatment and follow-up were carried out according to diagnoses, state of progression, and reversion (if any).

Conclusion

These findings underline a need for cervical lesion screening for all women during pregnancy, and colposcopy should be performed for pregnant women who have abnormal TCT results. Appropriate treatment and follow-up were recommended according to different diagnosis of CIN.

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Acknowledgments

This study was supported by grants from the Beijing Municipal Science and Technology Commission.

Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Gynecologic Oncology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, 100006, China

    Yu-Mei Wu, Tong Wang, Yue He, Fang Song, Yan Wang, Wei-Min Kong & Wei Duan

  2. Department of Pathology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, 100006, China

    Li Zhu

  3. Department of Obstetrics, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, 100006, China

    Wei-Yuan Zhang

Authors
  1. Yu-Mei Wu
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  2. Tong Wang
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  3. Yue He
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  4. Fang Song
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  5. Yan Wang
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  6. Li Zhu
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  7. Wei-Min Kong
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  8. Wei Duan
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  9. Wei-Yuan Zhang
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Correspondence to Yu-Mei Wu or Tong Wang.

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Wu, YM., Wang, T., He, Y. et al. Clinical management of cervical intraepithelial neoplasia in pregnant and postpartum women. Arch Gynecol Obstet 289, 1071–1077 (2014). https://doi.org/10.1007/s00404-013-3076-5

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  • DOI: https://doi.org/10.1007/s00404-013-3076-5

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