Skip to main content
SpringerLink
Log in

Twin pregnancy with a complete hydatidiform mole and co-existent live fetus: two case reports and review of the literature

  • Case Report
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Introduction

The aim of this study was to report the clinical features, management, and outcome of two cases of complete hydatidiform mole with a coexisting viable fetus and to review the literature.

Case reports

In this article, we report on the well-documented follow-up of two cases of twin pregnancies with complete hydatidiform mole and a normal fetus. Genetic amniocentesis showed normal fetal karyotype in both of two cases. In the first case, a live male infant was delivered by a cesarean section because of severe maternal bleeding at 29 weeks of gestation. In the second case, termination of pregnancy was performed due to early onset of severe preeclampsia and vaginal hemorrhage.

Conclusion

The chances of a live birth have been estimated between 30 and 35% and the risk of persistent trophoblastic disease is similar to singleton molar pregnancies in complete mole with coexisting fetus pregnancy. Therefore, in these pregnancies, expectant management instead of termination of pregnancy can be suggested.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. Suzuki M, Matsunobu A, Wakita K, Nishijima M, Osanai K (1980) Hydatidiform mole with a surviving coexisting fetus. Obstet Gynecol 56:384–388

    PubMed  CAS  Google Scholar 

  2. Vaisbuch E, Ben-Arie A, Dgani R, Perlman S, Sokolovsky N, Hagay Z (2006) Twin pregnancy consisting of a complete hydatidiform mole and co-existent fetus: report of two cases and review of literature. Gynecol Oncol 100:218–219. doi:10.1016/j.ygyno.2005.09.003

    Article  Google Scholar 

  3. Bristow RE, Shumway JB, Khouzami AN, Witter FR (1996) Complete hydatidiform mole and surviving coexistent twin. Obstet Gynecol Surv 51:705–709. doi:10.1097/00006254-199612000-00002

    Article  PubMed  CAS  Google Scholar 

  4. Steller MA, Genest DR, Bernstein MR, Lage JM, Goldstein DP, Berkowitz RS (1994) Clinical features of multiple conception with partial or complete molar pregnancy and coexisting fetuses. J Reprod Med 39:147–154

    PubMed  CAS  Google Scholar 

  5. Vejerslev LO, Sunde L, Hansen BF, Larsen JK, Christensen IJ, Larsen G (1991) Hydatidiform mole and fetus with normal karyotype: support of a separate entity. Obstet Gynecol 77:868–874

    PubMed  CAS  Google Scholar 

  6. Fishman DA, Padilla LA, Keh P, Cohen L, Frederiksen M, Lurain JR (1998) Management of twin pregnancies consisting of a complete hydatidiform mole and normal fetus. Obstet Gynecol 91:546–550. doi:10.1016/S0029-7844(97)00720-5

    Article  PubMed  CAS  Google Scholar 

  7. Garbin O, Favre R, Weber P, Arbogast E, Gasser B (1995) How to deal with a rare entity: the coexistence of a complete mole and a healthy egg in twin pregnancy? Fetal Diagn Ther 10:337–342

    Article  PubMed  CAS  Google Scholar 

  8. Ishii J, Iitsuka Y, Takano H, Matsui H, Osada H, Sekiya S (1998) Genetic differentiation of complete hydatidiform moles coexisting with normal fetuses by short tandem repeat derived deoxyribonucleic acid polymorphism analysis. Am J Obstet Gynecol 179:628–634. doi:10.1016/S0002-9378(98)70055-9

    Article  PubMed  CAS  Google Scholar 

  9. Marcorelles P, Audrezet MP, Le Bris MJ, Laurent Y, Chabaud JJ, Ferec C et al (2005) Diagnosis and outcome of complete hydatidiform mole coexisting with a live twin fetus. Eur J Obstet Gynecol Reprod Biol 118:21–27. doi:10.1016/j.ejogrb.2004.02.042

    Article  PubMed  Google Scholar 

  10. Sebire NJ, Foskett M, Paradinas FJ, Fisher RA, Francis RJ, Short D et al (2002) Outcome of twin pregnancies with complete hydatidiform mole and healthy co-twin. Lancet 359:2165–2166. doi:10.1016/S0140-6736(02)09085-2

    Article  PubMed  Google Scholar 

  11. Niemann I, Sunde L, Peterson LK (2007) Evaluation of the risk of persistent trophoblastic disease after twin pregnancy with diploid hydatidiform mole and coexisting normal fetus. Am J Obstet Gynecol 197:451–455

    Article  Google Scholar 

  12. Matsui H, Sekiya S, Hando T, Wake N, Tomoda Y (2000) Hydatidiform mole coexistent with a twin live fetus: a national collaborative study in Japan. Hum Reprod 15:608–611. doi:10.1093/humrep/15.3.608

    Article  PubMed  CAS  Google Scholar 

  13. Sebire NJ (2006) Prenatal diagnosis and management of twin pregnancies complicated by a co-existing molar pregnancy. Prenat Diagn 26(4):373. doi:10.1002/pd.1380

    Article  PubMed  Google Scholar 

  14. Shahabi S, Naome G, Cobin L, Veroughstruele A, Musters L, Zengbe V et al (1977) Complete hydatidiform mole and coexisting fetus. A case report of two cases with contrasting outcomes. J Reprod Med 42:756–760

    Google Scholar 

  15. Block MF, Merill JA (1982) Hydatidifrom mole with coexistent fetus. Obstet Gynecol 60:129–134

    PubMed  CAS  Google Scholar 

  16. Miller D, Jackson R, Ehlen T, McMurtie E (1993) Complete hydatidiform mole coexistent with a twin live fetus. Clinical course of four cases with complete cytogenic analysis. Gynecol Oncol 50:119–123. doi:10.1006/gyno.1993.1175

    Article  PubMed  CAS  Google Scholar 

  17. Jinno M, Ubukata Y, Hanya I, Satou M, Yoshimura Y, Nakamura Y (1994) Hydatidiform mole with a surviving coexistent fetus following in-vitro fertilization. Hum Reprod 9:1770–1772

    PubMed  CAS  Google Scholar 

  18. Anderson CK, Deiter RWM, Motz MJ, Goldstein JA (1996) Complete hydatidiform mole with a coexistent healthy, viable fetus near term: a case report. J Reprod Med 41:55–58

    PubMed  CAS  Google Scholar 

  19. Chen EP (1997) Molar pregnancy and living normal fetus coexistent until term: prenatal biochemical and sonographic diagnosis. Hum Reprod 12:853–856. doi:10.1093/humrep/12.4.853

    Article  PubMed  CAS  Google Scholar 

  20. Montes-de-Oca-Valero F, Macara L, Shaker A (1999) Twin pregnancy with a complete mole and co-existing fetus following in-vitro fertilization. Hum Reprod 14:2905–2907. doi:10.1093/humrep/14.11.2905

    Article  PubMed  CAS  Google Scholar 

  21. Abbi M, Kriplani A, Uppal R, Takkar D (1999) Term twin pregnancy with hydatidiform mole and normal fetus. Arch Gynecol Obstet 262:189–191. doi:10.1007/s004040050248

    Article  PubMed  CAS  Google Scholar 

  22. Amr MF, Fisher RA, Foskett MA, Paradinas FJ (2000) Triplet pregnancy with hydatidiform mole. Int J Gynecol Cancer 10:76–81. doi:10.1046/j.1525-1438.2000.99064.x

    Article  PubMed  Google Scholar 

  23. Bruchim I, Kidron D, Amiel A, Altaras M, Fejgin MD (2000) Complete hydatidiform mole and a coexistent viable fetus: report to two cases and review of the literature. Gynecol Oncol 77:197–202. doi:10.1006/gyno.2000.5733

    Article  PubMed  CAS  Google Scholar 

  24. Makrydimas G, Sebire HJ, Thornton SE, Zagorianakou N, Lolis D, Fisher RA (2002) Complete hydatidiform mole and normal live birth: a novel case of conWned placental mosaicism. Hum Reprod 17:2459–2463. doi:10.1093/humrep/17.9.2459

    Article  PubMed  CAS  Google Scholar 

  25. Wax JR, Pinette MG, Chard R, Blackstone J, Cartin A (2003) Prenatal diagnosis by DNA polymorphism analysis of complete mole with coexisting twin. Am J Obstet Gynecol 188:1105–1106. doi:10.1067/mob.2003.151

    Article  PubMed  Google Scholar 

  26. Moini A, Riazi K (2003) Molar pregnancy with a coexisting fetus progressing to a viable infant. Int J Gynaecol Obstet 82:63–64. doi:10.1016/S0020-7292(03)00039-0

    Article  PubMed  CAS  Google Scholar 

  27. Bovicelli L, Ghi T, Pilu G, Farina A, Savelli L, Simonazzi G et al (2004) Prenatal diagnosis of a complete mole coexisting with a dichorionic twin pregnancy: case report. Hum Reprod 19:1231–1234. doi:10.1093/humrep/deh211

    Article  PubMed  CAS  Google Scholar 

  28. Hyodo M, Samura O, Miharu N, Ohama K, Kudo Y (2005) Molar DNA in maternal serum in a case of 46, XY heterozygous complete hydatidiform mole coexisting with a 46, XX twin live fetus. Clin Chem 51:676–677. doi:10.1373/clinchem.2004.043034

    Article  PubMed  CAS  Google Scholar 

  29. Lambert-Messerlian G, Pinar H, Rubin LP, De Paepe ME, Tantravahi U, Steinhoff MM et al (2005) Second-trimester maternal serum markers in twin pregnancy with complete mole: report of 2 cases. Pediatr Dev Pathol 8:230–234. doi:10.1007/s10024-005-0121-9

    Article  PubMed  Google Scholar 

  30. Hamanoue H, Umezu N, Okuda M, Harada N, Ohata T, Sakai H et al (2006) Complete hydatidiform mole and normal live birth following intracytoplasmic sperm injection. J Hum Genet 51:477–479. doi:10.1007/s10038-006-0388-3

    Article  PubMed  Google Scholar 

  31. Klatt TE, Franciosi RA, Cruikshank DP (2006) Normal fetus with a twin presenting as both a complete hydatidiform mole and placenta previa. Obstet Gynecol 107:527–530

    PubMed  Google Scholar 

  32. Piura B, Rabinovich A, Hershkovitz R, Maor E, Mazor M (2008) Twin pregnancy with a complete hydatidiform mole and surviving co-existent fetus. Arch Gynecol Obstet. 2008 Feb 14. [Epub ahead of print]

Download references

Author information

Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Faculty of Medicine, Mustafa Kemal University, Antakya, Hatay, Turkey

    Kenan Dolapcioglu, Arif Gungoren & Ali Ulvi Hakverdi

  2. Department of Pathology, Faculty of Medicine, Mustafa Kemal University, Antakya, Hatay, Turkey

    Sibel Hakverdi

  3. Department of Radiology, Faculty of Medicine, Mustafa Kemal University, Antakya, Hatay, Turkey

    Ertugrul Egilmez

  4. MKU Arastirma Hastanesi, 3110, Antakya, Hatay, Turkey

    Kenan Dolapcioglu

Authors
  1. Kenan Dolapcioglu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Arif Gungoren
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Sibel Hakverdi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Ali Ulvi Hakverdi
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Ertugrul Egilmez
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Kenan Dolapcioglu.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Dolapcioglu, K., Gungoren, A., Hakverdi, S. et al. Twin pregnancy with a complete hydatidiform mole and co-existent live fetus: two case reports and review of the literature. Arch Gynecol Obstet 279, 431–436 (2009). https://doi.org/10.1007/s00404-008-0737-x

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00404-008-0737-x

Keywords

Search

Navigation