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Lymphoepithelioma-like carcinoma of the uterine cervix: absence of Epstein-Barr virus and high-risk human papilloma virus infection

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Abstract

Objective

Lymphoepithelioma-like carcinoma (LELC) is a rare variant of squamous cell carcinoma of the uterine cervix. In contrast to Asian women, Caucasian women have a low prevalence of cervical LELC with no infection of the Epstein-Barr virus (EBV) and sporadic appearances of human papilloma viruses (HPV) in Caucasian women.

Case

We report a 36-year-old female Caucasian patient with LELC of the cervix.

Result

In contrast to the present studies, our case of LELC of the cervix is not associated with EBV or high-risk HPV appearances.

Conclusion

This is the first study, that showed no relationship between LELC of the uterine cervix with EBV and high-risk HPV infections in a Caucasian woman.

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References

  1. Iezzoni JC, Gaffey MJ, Weiss LM (1995) The role of Epstein-Barr virus in lymphoepithelioma-like carcinomas. Am J Clin Pathol 103(3):308–315

    PubMed  CAS  Google Scholar 

  2. Lopez-Rios F, Miguel PS, Bellas C, Ballestin C, Hernandez L (2000) Lymphoepithelioma-like carcinoma of the uterine cervix: a case report studied by in situ hybridization and polymerase chain reaction for Epstein-Barr virus. Arch Pathol Lab Med 124(5):746–747

    PubMed  CAS  Google Scholar 

  3. Martinez-Leandro EP, Martorell M, Alemany P, Salvador I, Garcia-Guardiet E (1994) Lymphoepithelial-like carcinoma of the uterine cervix. Study of a case with in situ hybridization of the Epstein-Barr virus genome and the human papillomavirus genome. Acta Obstet Gynecol Scand 73(7):589–592

    Article  PubMed  CAS  Google Scholar 

  4. Martorell MA, Julian JM, Calabuig C, Garcia-Garcia JA, Perez-Valles A (2002) Lymphoepithelioma-like carcinoma of the uterine cervix. Arch Pathol Lab Med 126(12):1501–1505

    PubMed  Google Scholar 

  5. Matias-Guiu X, Komminoth P, Prat J (1994) Absence of Epstein-Barr virus DNA in lymphoepithelioma-like carcinoma of the uterine cervix. Am J Clin Pathol 101(1):117

    PubMed  CAS  Google Scholar 

  6. Saylam K, Anaf V, Fayt I, Noel JC (2002) Lymphoepithelioma-like carcinoma of the cervix with prominent eosinophilic infiltrate: an HPV-18 associated case. Acta Obstet Gynecol Scand 81(6):564–566

    Article  PubMed  Google Scholar 

  7. Tseng CJ, Pao CC, Tseng LH, Chang CT, Lai CH, Soong YK, Hsueh S, Jyu-Jen H (1997) Lymphoepithelioma-like carcinoma of the uterine cervix: association with Epstein-Barr virus and human papillomavirus. Cancer 80(1):91–97

    Article  PubMed  CAS  Google Scholar 

  8. Weinberg E, Hoisington S, Eastman AY, Rice DK, Malfetano J, Ross JS (1993) Uterine cervical lymphoepithelial-like carcinoma. Absence of Epstein-Barr virus genomes. Am J Clin Pathol 99(2):195–199

    PubMed  CAS  Google Scholar 

  9. Bais AG, Kooi S, Teune TM, Ewing PC, Ansink AC (2005) Lymphoepithelioma-like carcinoma of the uterine cervix: absence of Epstein- Barr virus, but presence of a multiple human papillomavirus infection. Gynecol Oncol 97(2):716–718

    Article  PubMed  Google Scholar 

  10. Walboomers JMM, Jacobs MV, Manos MM, Bosch F X JA et al (1999) Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J Pathol 189:12-19

    Article  PubMed  CAS  Google Scholar 

  11. Noel J, Lespagnard L, Fayt I, Verhest A, Dargent J (2001) Evidence of human papilloma virus infection but lack of Epstein-Barr virus in lymphoepithelioma-like carcinoma of uterine cervix: report of two cases and review of the literature. Hum Pathol 32(1):135–138

    Article  PubMed  CAS  Google Scholar 

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Competing interests

The authors declare that they have no competing interests.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, University of Wuerzburg, Josef-Schneider-Str. 4, 97080, Wuerzburg, Germany

    N. Kohrenhagen & J. Dietl

  2. Department of Obstetrics and Gynecology, University of Wuerzburg, Josef-Schneider-Str. 4, 97080, Wuerzburg, Germany

    M. Eck & S. Höller

Authors
  1. N. Kohrenhagen
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  2. M. Eck
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  3. S. Höller
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  4. J. Dietl
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Corresponding author

Correspondence to N. Kohrenhagen.

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Kohrenhagen, N., Eck, M., Höller, S. et al. Lymphoepithelioma-like carcinoma of the uterine cervix: absence of Epstein-Barr virus and high-risk human papilloma virus infection. Arch Gynecol Obstet 277, 175–178 (2008). https://doi.org/10.1007/s00404-007-0427-0

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  • DOI: https://doi.org/10.1007/s00404-007-0427-0

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