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Study of MDM2 and SUMO-1 expression in actinic cheilitis and lip cancer

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Abstract

Actinic cheilitis exhibits a potential of malignant transformation in 10–20 % of cases. The objective of this study was to compare the expression of MDM2 and SUMO-1 proteins between actinic cheilitis (AC) and squamous cell carcinoma (SCC) of the lip. The sample consisted of lower lip mucosa specimens obtained from cases with a clinical and histopathological diagnosis of AC (n = 26) and SCC (n = 25) and specimens of labial semi-mucosa (n = 15) without clinical alterations or inflammation. The tissue samples were stained with hematoxylin-eosin and anti-MDM2 and anti-SUMO-1 antibodies. Data were analyzed by the Kruskal–Wallis and Dunn’s tests (5 %). The median expression of MDM2 (kW = 36.8565; df = 3−1 = 2; p = 0.0001) and SUMO-1 (kW = 32.7080; df = 3−1 = 2; p = 0.0001) was similar in cases of AC and SCC of the lip, but differed significantly from that observed for normal labial semi-mucosa. Despite the limitations of the present study, immunohistochemistry demonstrated the overexpression of important proteins (MDM2 and SUMO-1) related to regulatory mechanisms of apoptosis in AC and SCC of the lip, but further studies are needed.

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Acknowledgments

To National Council of Technological and Scientific Development, Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) for financial support, and CIPAX (Medicina diagnóstica) for positive control tissue sections.

Conflict of interest

The authors declare that they have no competing interests.

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Authors and Affiliations

  1. Department of Biosciences and Oral Diagnosis, Institute of Science and Technology, UNESP, Univ Estadual Paulista, 777 Engenheiro Francisco José Longo Avenue, São Dimas, São José Dos Campos, SP, 12245-000, Brazil

    Mônica Ghislaine Oliveira Alves, Adriana da Mota Delgado, Yasmin Rodarte Carvalho, Ana Sueli Rodrigues Cavalcante & Janete Dias Almeida

  2. Department of Social Science and Pediatric Dentistry, Institute of Science and Technology, UNESP, Univ Estadual Paulista, 777 Av Engenheiro Francisco José Longo, São José dos Campos, SP, 12245-000, Brazil

    Ivan Balducci

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  1. Mônica Ghislaine Oliveira Alves
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  2. Adriana da Mota Delgado
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  3. Ivan Balducci
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  4. Yasmin Rodarte Carvalho
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  5. Ana Sueli Rodrigues Cavalcante
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  6. Janete Dias Almeida
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Correspondence to Mônica Ghislaine Oliveira Alves.

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Oliveira Alves, M.G., da Mota Delgado, A., Balducci, I. et al. Study of MDM2 and SUMO-1 expression in actinic cheilitis and lip cancer. Arch Dermatol Res 306, 837–841 (2014). https://doi.org/10.1007/s00403-014-1500-8

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  • DOI: https://doi.org/10.1007/s00403-014-1500-8

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