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Interleukin-1 family members are enhanced in psoriasis and suppressed by vitamin D and retinoic acid

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Abstract

Interleukin (IL)-1 family comprise 11 members that play an important role in immune regulation and inflammatory process. Retinoids exert complex effects on the immune system, having anti-inflammatory effects in chronic dermatological diseases. Vitamin D (vitD) and analogs have been shown to suppress TNF-α-induced IL-1α in human keratinocytes (KCs). In the present study, we investigated IL-1 family members in psoriasis and the effects of vitD and retinoic acid (RA) on these members. We analyzed IL-1 family members gene expression in psoriatic skin and in ex vivo skin organ culture exposed to TNF-α, IL-17 or broadband UVB; afterwards, treatment with vitD or RA was performed and IL-1 family members mRNA was evaluated. Similarly, KCs were stimulated with IL-17 and subsequently treated with vitD. IL-1 family members were enhanced in psoriatic skin and in ex vivo skin organ cultures after pro-inflammatory stimuli (TNF-α, IL-17 and UVB). RA and vitD were able to suppress this enhancement.

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Conflict of interest

The authors have no conflict of interest to declare.

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Authors and Affiliations

  1. Department of Dermatology, University of Naples Federico II, Via Pansini, 5, 80131, Naples, Italy

    Anna Balato, Maria Schiattarella, Serena Lembo, Martina Mattii, Nicola Balato & Fabio Ayala

  2. Department of Clinical Immunology and Allergy, University of Naples Federico II, Naples, Italy

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  1. Anna Balato
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  2. Maria Schiattarella
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  3. Serena Lembo
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  4. Martina Mattii
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  7. Fabio Ayala
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Correspondence to Anna Balato.

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Balato, A., Schiattarella, M., Lembo, S. et al. Interleukin-1 family members are enhanced in psoriasis and suppressed by vitamin D and retinoic acid. Arch Dermatol Res 305, 255–262 (2013). https://doi.org/10.1007/s00403-013-1327-8

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  • DOI: https://doi.org/10.1007/s00403-013-1327-8

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