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Recommendations for detection of individual risk for comorbidities in patients with psoriasis

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Abstract

Since the pathogenesis of psoriasis vulgaris is now understood as a T cell mediated systemic auto-immune disease, the awareness for the potential systemic implications of the chronic active inflammation has grown. By evaluation of patient registries and study data, several complexes of comorbidities could be identified in recent years, albeit not all of them being clinically relevant. Comorbidity in this context will be defined as two or more diagnostically distinguished medical conditions existing simultaneously, but without a causal link. Nevertheless, there is some strong indication for pathogenetic link between some specified comorbidities and psoriasis at molecular and immunological level. The need for an interdisciplinary assessment of the potential interrelation is obvious. In order to detect the individual risk for comorbidities in patients with moderate to severe psoriasis and to recommend the course of action, a checklist has been developed at an interdisciplinary level that is reduced to the quintessential points for the use in daily practice.

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Acknowledgments

The initiative group would like to thank Pfizer Germany GmbH for financially supporting the organisational framework of the project. Pfizer has had no content-related influence on the project. Further, the authors would like to thank the German Cardiac Society, the German Society of Endocrinology as well as the German Association for Psychiatry and Psychotherapy for their support, advice and co-operation.

Conflict of interest

The following authors have received fees for lecturing and/or consulting, and/or received funding for scientific projects or clinical studies from sponsors that market products for indications mentioned in the article: JW: Abbott, Biogen-Idec, Janssen-Cilag, Leo, MSD, Novartis, Pfizer; SG: Pfizer; AN: Abbott, Bayer Health Care, Janssen-Cilag, Pfizer; MR: Pfizer; DT: Abbott, Astellas, Biogen-Idec, Janssen-Cilag, Leo, MSD, Novartis, Pfizer. GF, SP, WK, AP, MH and MS declare to have no conflict of interest.

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Authors and Affiliations

  1. Department of Dermatology and Venereology, Martin-Luther-University Halle-Wittenberg, Ernst-Kromayer-Strasse 5, 06097, Halle (Saale), Germany

    Johannes Wohlrab

  2. Dermatological practice, Weißenfels, Germany

    Gabriele Fiedler

  3. Department of Dermatology, Allergology and Venereology (Psoriasis-Centre) of University Medical Centre Schleswig-Holstein, Campus Kiel, Kiel, Germany

    Sascha Gerdes

  4. Division of Evidence Based Medicine, University Clinic and Policlinic of Dermatology, Allergology and Venereology, Charité, University Medicine Berlin, Berlin, Germany

    Alexander Nast

  5. University Clinic and Policlinic of Dermatology, Allergology and Venereology, Charité, University Medicine Berlin, Berlin, Germany

    Sandra Philipp

  6. Institute for Health Services Research in Dermatology and Nursing, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany

    Marc A. Radtke

  7. Department of Dermatology, Venereology and Allergology, J.W. Goethe University Hospital and Faculty of Medicine Frankfurt am Main, Frankfurt, Germany

    Diamant Thaçi

  8. Department of Internal Medicine II—Cardiology, Centre for Internal Medicine, University of Ulm, Ulm, Germany

    Wolfgang Koenig

  9. Endocrinology, Diabetes and Nutrition Medicine, Charité, University Medicine Berlin, Berlin, Germany

    Andreas F. H. Pfeiffer

  10. Department of Medical Psychology, Centre for Psychosocial Medicine, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany

    Martin Härter

  11. Department of Dermatology, Venereology and Allergology, University Medical Centre Göttingen, Göttingen, Germany

    Michael P. Schön

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  1. Johannes Wohlrab
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Wohlrab, J., Fiedler, G., Gerdes, S. et al. Recommendations for detection of individual risk for comorbidities in patients with psoriasis. Arch Dermatol Res 305, 91–98 (2013). https://doi.org/10.1007/s00403-013-1318-9

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