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Possible contribution of GSTP1 and other xenobiotic metabolizing genes to vitiligo susceptibility

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Abstract

Vitiligo is an acquired pigmentary disorder with several proposed pathogenesis mechanisms and complex multifactorial genetic predisposition. We analyzed 65 polymorphisms in genes potentially relevant to vitiligo pathogenesis mechanism to reveal novel and confirm reported genetic risk factors in general Russian population. We found that polymorphism rs1138272 (TC + CC) in GSTP1 gene encoding enzyme involved in xenobiotic metabolism is associated with vitiligo (Bonferroni adjusted P value 0.0015) with extraordinary high odds ratio 13.03, and haplotype analysis confirmed association of GSTP1 gene with vitiligo risk. Moreover, analysis of variations in several genes encoding enzymes of xenobiotic metabolism showed that higher risk of vitiligo is associated with higher number of risk alleles. This finding reveals possible contribution of genetic background to observed imbalance of oxidative stress control in vitiligo through cumulative effect of multiple genetic variations in xenobiotic metabolizing genes, supporting the concept of multigenic nature of vitiligo with multiple low-risk alleles cumulatively contributing to vitiligo risk.

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Acknowledgments

Authors are grateful to Ekaterina A. Bessonova for excellent technical assistance. The work was supported by the Vitiligo Research Foundation (VR Foundation).

Conflict of interest

The authors declare no conflict of interest.

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Authors and Affiliations

  1. Center for Innovative Biotechnologies “Allele”, Moscow, Russia

    Mikhail M. Minashkin & Andrey O. Tatarenko

  2. Institute of Gene Biology, Russian Academy of Sciences, 34/5 Vavilov Street, Moscow, 119334, Russia

    Lubov E. Salnikova & Igor V. Korobko

  3. N.I. Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russia

    Lubov E. Salnikova

  4. Vitiligo Research Foundation, New York, NY, USA

    Igor V. Korobko

  5. Department of Skin and Venereal Diseases, I.M. Sechenov Moscow Medical Academy, Moscow, Russia

    Konstantin M. Lomonosov

Authors
  1. Mikhail M. Minashkin
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  2. Lubov E. Salnikova
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  3. Konstantin M. Lomonosov
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  4. Igor V. Korobko
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  5. Andrey O. Tatarenko
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Corresponding author

Correspondence to Igor V. Korobko.

Additional information

M. M. Minashkin and L. E. Salnikova contributed equally to this work.

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Minashkin, M.M., Salnikova, L.E., Lomonosov, K.M. et al. Possible contribution of GSTP1 and other xenobiotic metabolizing genes to vitiligo susceptibility. Arch Dermatol Res 305, 233–239 (2013). https://doi.org/10.1007/s00403-012-1301-x

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  • DOI: https://doi.org/10.1007/s00403-012-1301-x

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