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Design and synthesis of gold-loaded micelles based on poly (ethylene glycol) and poly (4-vinyl pyridine) triblock copolymers for biomedical applications

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Abstract

Gold-loaded micelles were prepared using triblock copolymers based on poly (ethylene glycol) and poly (4-vinyl pyridine) (P4VP-b-PEG-b-P4VP) obtained via atom transfer radical polymerization (ATRP). This was achieved using novel dichloro-terminated PEG as a macroinitiator. Further, ATRP was performed using 4-VP as a second forming block in the presence of CuCl/PMDETA as a catalyst system. The successful formation of P4VP-b-PEG-b-P4VP block copolymers was proved by FT-IR and 1H NMR with the presence of all characteristic signals arising from PEG and 4-VP units. The self-assembling behavior of thus prepared block copolymer in an aqueous media was investigated. Further, gold nanoparticles were embedded into the P4VP core of the micelles. Cell viability of the gold-loaded micelles was proven by MTT test as they showed no cytotoxicity on cancerous and non-cancerous cells.

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Acknowledgements

This study was supported by the Scientific Research Center at UCTM Sofia, Bulgaria, grant no. 11513.

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Authors and Affiliations

  1. Department of Polymer Engineering, University of Chemical Technology and Metallurgy, 8 Kl. Ohridski Blvd, 1756, Sofia, Bulgaria

    R. Bryaskova, S. Vircheva, S. Miloshev & N. Dishovsky

  2. Institute of Biophysics and Biomedical Engineering, Bulgarian Academy of Science, Acad. G. Bonchev Str., Bl.21, 1113, Sofia, Bulgaria

    R. Tzoneva

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  1. R. Bryaskova
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  2. S. Vircheva
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  3. S. Miloshev
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  4. N. Dishovsky
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Correspondence to R. Bryaskova.

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Bryaskova, R., Vircheva, S., Miloshev, S. et al. Design and synthesis of gold-loaded micelles based on poly (ethylene glycol) and poly (4-vinyl pyridine) triblock copolymers for biomedical applications. Colloid Polym Sci 295, 487–494 (2017). https://doi.org/10.1007/s00396-017-4025-9

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  • DOI: https://doi.org/10.1007/s00396-017-4025-9

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