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Microfluidic immobilization of polyglycerin-b-poly(ε-caprolactone) polymeric micelles in uniform zwitterionic hydrogel microparticles for molecular network-mediated drug release

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Abstract

This study introduces a flexible and straightforward method for immobilization of polymeric micelles in monodisperse suspensions of hydrogel microparticles. Hydrogel particles loaded with polyglycerin-b-poly(ε-caprolactone) micelles were prepared using a capillary-based microfluidic method. For this, a uniform water-in-oil emulsion was generated in a microfluidic device. The aqueous dispersion drops contain polymeric micelles, monomers, and photo-initiators. Then, the emulsion drops were photo-polymerized to transfer them to hydrogel particles. The hydrogel phase was made of poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC) that has an enhanced biocompatibility due to the phosphorylcholine moiety in the backbone. Finally, we have demonstrated that the microfluidic approach is indeed useful for physically immobilizing polymeric micelles in between PMPC hydrogel meshes, which provides a means to regulate the release behavior of active ingredients encapsulated in the polymeric micelles.

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Acknowledgments

This work was supported by a grant of the Korea Healthcare Technology R&D Project, Ministry of Health & Welfare, and Republic of Korea (Grant No. A103017). This research was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) (2012R1A1A2039).

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Authors and Affiliations

  1. Department of Bionano Technology, Hanyang University, Ansan, Gyeonggi-do, 426-791, Republic of Korea

    Jonghee Park, Eun Seon Jeong, Sinae Kim & Jin Woong Kim

  2. Department of Materials Science and Engineering, Yonsei University, Seoul, 120-749, Republic of Korea

    Yong-Jin Kim

  3. Development Group for Global New Drug Developing Human Resources (BK21 Plus Project), School of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi-do, 440-746, Republic of Korea

    Hye-Jin Jeong

  4. Department of Applied Chemistry, Hanyang University, 55 Hanyangdaehak-ro, Sangnok-gu, Ansan, Gyeonggi-do, 426-791, Republic of Korea

    Jin Woong Kim

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  1. Jonghee Park
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  2. Eun Seon Jeong
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  3. Sinae Kim
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  4. Yong-Jin Kim
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Correspondence to Hye-Jin Jeong or Jin Woong Kim.

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Park, J., Jeong, E.S., Kim, S. et al. Microfluidic immobilization of polyglycerin-b-poly(ε-caprolactone) polymeric micelles in uniform zwitterionic hydrogel microparticles for molecular network-mediated drug release. Colloid Polym Sci 293, 1121–1127 (2015). https://doi.org/10.1007/s00396-014-3493-4

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  • DOI: https://doi.org/10.1007/s00396-014-3493-4

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