Skip to main content
SpringerLink
Log in

Clinical significance of conduction disturbances after aortic valve intervention: current evidence

  • Review
  • Published:
Clinical Research in Cardiology Aims and scope Submit manuscript

Abstract

The occurrence of new conduction abnormalities that lead to the requirement for new permanent pacemaker implantation (PPI) has been reported to be the most frequent complication following transcatheter aortic valve implantation (TAVI). However, the reasons and clinical significance of TAVI-induced conduction disturbances and PPI are yet to be fully delineated. This review aims to evaluate the procedure- and patient-related factors that may contribute to the development of aberrant atrioventricular conduction following TAVI as well as its clinical consequences.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Nkomo VT, Gardin JM, Skelton TN, Gottdiener JS, Scott CG, Enriquez-Sarano M (2006) Burden of valvular heart diseases: a population-based study. Lancet 368:1005–1011

    Article  PubMed  Google Scholar 

  2. Osnabrugge RL, Mylotte D, Head SJ, Van Mieghem NM, Nkomo VT, LeReun CM, Bogers AJ, Piazza N et al (2013) Aortic stenosis in the elderly: disease prevalence and number of candidates for transcatheter aortic valve replacement: a meta-analysis and modeling study. J Am Coll Cardiol 62:1002–1012

    Article  PubMed  Google Scholar 

  3. Cribier A (2012) Development of transcatheter aortic valve implantation (TAVI): a 20-year odyssey. Arch Cardiovasc Dis 105:146–152

    Article  PubMed  Google Scholar 

  4. McMurray JJ, Adamopoulos S, Anker SD, Auricchio A, Bohm M, Dickstein K, Falk V, Filippatos G et al (2012) ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC. Eur Heart J 33:1787–1847

    Article  PubMed  Google Scholar 

  5. Tang GH, Lansman SL, Cohen M, Spielvogel D, Cuomo L, Ahmad H, Dutta T (2013) Transcatheter aortic valve replacement: current developments, ongoing issues, future outlook. Cardiol Rev 21:55–76

    Article  PubMed  Google Scholar 

  6. Neragi-Miandoab S, Michler RE (2013) A review of most relevant complications of transcatheter aortic valve implantation. ISRN Cardiol 2013:956252

    PubMed Central  PubMed  Google Scholar 

  7. Kappetein AP, Head SJ, Genereux P, Piazza N, van Mieghem NM, Blackstone EH, Brott TG, Cohen DJ et al (2013) Updated standardized endpoint definitions for transcatheter aortic valve implantation: the Valve Academic Research Consortium-2 consensus document. J Thorac Cardiovasc Surg 145:6–23

    Article  PubMed  Google Scholar 

  8. Roten L, Meier B (2014) Left bundle branch block after transcatheter aortic valve implantation: still a matter of concern? JACC Cardiovasc Interv 7:137–139

    Article  PubMed  Google Scholar 

  9. Colombo A, Latib A (2012) Left bundle branch block after transcatheter aortic valve implantation: inconsequential or a clinically important endpoint? J Am Coll Cardiol 60:1753–1755

    Article  PubMed  Google Scholar 

  10. Fraccaro C, Napodano M, Tarantini G (2013) Conduction disorders in the setting of transcatheter aortic valve implantation: a clinical perspective. Catheter Cardiovasc Interv 81:1217–1223

    Article  PubMed  Google Scholar 

  11. Khatri PJ, Webb JG, Rodes-Cabau J, Fremes SE, Ruel M, Lau K, Guo H, Wijeysundera HC et al (2013) Adverse effects associated with transcatheter aortic valve implantation: a meta-analysis of contemporary studies. Ann Intern Med 158:35–46

    Article  PubMed  Google Scholar 

  12. Van Mieghem NM, Head SJ, de Jong W, van Domburg RT, Serruys PW, de Jaegere PP, Jordaens L, Takkenberg JJ et al (2012) Persistent annual permanent pacemaker implantation rate after surgical aortic valve replacement in patients with severe aortic stenosis. Ann Thorac Surg 94:1143–1149

    Article  PubMed  Google Scholar 

  13. Roten L, Stortecky S, Scarcia F, Kadner A, Tanner H, Delacretaz E, Meier B, Windecker S et al (2012) Atrioventricular conduction after transcatheter aortic valve implantation and surgical aortic valve replacement. J Cardiovasc Electrophysiol 23:1115–1122

    Article  PubMed  Google Scholar 

  14. Bagur R, Rodes-Cabau J, Gurvitch R, Dumont E, Velianou JL, Manazzoni J, Toggweiler S, Cheung A et al (2012) Need for permanent pacemaker as a complication of transcatheter aortic valve implantation and surgical aortic valve replacement in elderly patients with severe aortic stenosis and similar baseline electrocardiographic findings. JACC Cardiovasc Interv 5:540–551

    Article  PubMed  Google Scholar 

  15. Simms AD, Hogarth AJ, Hudson EA, Worsnop VL, Blackman DJ, O’Regan DJ, Tayebjee MH (2013) Ongoing requirement for pacing post-transcatheter aortic valve implantation and surgical aortic valve replacement. Interact Cardiovasc Thorac Surg 17:328–333

    Article  PubMed Central  PubMed  Google Scholar 

  16. El-Khally Z, Thibault B, Staniloae C, Theroux P, Dubuc M, Roy D, Guerra P, Macle L et al (2004) Prognostic significance of newly acquired bundle branch block after aortic valve replacement. Am J Cardiol 94:1008–1011

    Article  PubMed  Google Scholar 

  17. Kalavrouziotis D, Li D, Buth KJ, Legare JF (2009) The European System for Cardiac Operative Risk Evaluation (EuroSCORE) is not appropriate for withholding surgery in high-risk patients with aortic stenosis: a retrospective cohort study. J Cardiothorac Surg 4:32

    Article  PubMed Central  PubMed  Google Scholar 

  18. Akin I, Kische S, Paranskaya L, Schneider H, Rehders TC, Trautwein U, Turan G, Bansch D et al (2012) Predictive factors for pacemaker requirement after transcatheter aortic valve implantation. BMC Cardiovasc Disord 12:87

    Article  PubMed Central  PubMed  Google Scholar 

  19. Baan J Jr, Yong ZY, Koch KT, Henriques JP, Bouma BJ, Vis MM, Cocchieri R, Piek JJ et al (2010) Factors associated with cardiac conduction disorders and permanent pacemaker implantation after percutaneous aortic valve implantation with the CoreValve prosthesis. Am Heart J 159:497–503

    Article  PubMed  Google Scholar 

  20. Bleiziffer S, Ruge H, Horer J, Hutter A, Geisbusch S, Brockmann G, Mazzitelli D, Bauernschmitt R et al (2010) Predictors for new-onset complete heart block after transcatheter aortic valve implantation. JACC Cardiovasc Interv 3:524–530

    Article  PubMed  Google Scholar 

  21. Buellesfeld L, Stortecky S, Heg D, Hausen S, Mueller R, Wenaweser P, Pilgrim T, Gloekler S et al (2012) Impact of permanent pacemaker implantation on clinical outcome among patients undergoing transcatheter aortic valve implantation. J Am Coll Cardiol 60:493–501

    Article  PubMed  Google Scholar 

  22. Franzoni I, Latib A, Maisano F, Costopoulos C, Testa L, Figini F, Giannini F, Basavarajaiah S et al (2013) Comparison of incidence and predictors of left bundle branch block after transcatheter aortic valve implantation using the CoreValve versus the Edwards valve. Am J Cardiol 112:554–559

    Article  PubMed  Google Scholar 

  23. Goldenberg G, Kusniec J, Kadmon E, Golovchiner G, Zabarsky R, Nevzorov R, Vaknin H, Assali A et al (2013) Pacemaker implantation after transcatheter aortic valve implantation. Am J Cardiol 112:1632–1634

    Article  PubMed  Google Scholar 

  24. Grube E, Naber C, Abizaid A, Sousa E, Mendiz O, Lemos P, Kalil Filho R, Mangione J et al (2011) Feasibility of transcatheter aortic valve implantation without balloon pre-dilation: a pilot study. JACC Cardiovasc Interv 4:751–757

    Article  PubMed  Google Scholar 

  25. Koos R, Mahnken AH, Aktug O, Dohmen G, Autschbach R, Marx N, Hoffmann R (2011) Electrocardiographic and imaging predictors for permanent pacemaker requirement after transcatheter aortic valve implantation. J Heart Valve Dis 20:83–90

    PubMed  Google Scholar 

  26. Liang M, Devlin G, Pasupati S (2012) The incidence of transcatheter aortic valve implantation-related heart block in self-expandable Medtronic CoreValve and balloon-expandable Edwards valves. J Invasive Cardiol 24:173–176

    PubMed  Google Scholar 

  27. Mouillet G, Lellouche N, Lim P, Meguro K, Yamamoto M, Deux JF, Monin JL, Bergoend E et al (2013) Patients without prolonged QRS after TAVI with CoreValve device do not experience high-degree atrio-ventricular block. Catheter Cardiovasc Interv 81:882–887

    Article  PubMed  Google Scholar 

  28. Pereira E, Ferreira N, Caeiro D, Primo J, Adao L, Oliveira M, Goncalves H, Ribeiro J et al (2013) Transcatheter aortic valve implantation and requirements of pacing over time. Pacing Clin Electrophysiol 36:559–569

    Article  PubMed  Google Scholar 

  29. Piazza N, Onuma Y, Jesserun E, Kint PP, Maugenest AM, Anderson RH, de Jaegere PP, Serruys PW (2008) Early and persistent intraventricular conduction abnormalities and requirements for pacemaking after percutaneous replacement of the aortic valve. JACC Cardiovasc Interv 1:310–316

    Article  PubMed  Google Scholar 

  30. Piazza N, Nuis RJ, Tzikas A, Otten A, Onuma Y, Garcia-Garcia H, Schultz C, van Domburg R et al (2010) Persistent conduction abnormalities and requirements for pacemaking 6 months after transcatheter aortic valve implantation. Eurointervention 6:475–484

    Article  PubMed  Google Scholar 

  31. Roten L, Wenaweser P, Delacretaz E, Hellige G, Stortecky S, Tanner H, Pilgrim T, Kadner A et al (2010) Incidence and predictors of atrioventricular conduction impairment after transcatheter aortic valve implantation. Am J Cardiol 106:1473–1480

    Article  PubMed  Google Scholar 

  32. Saia F, Lemos PA, Bordoni B, Cervi E, Boriani G, Ciuca C, Taglieri N, Mariani J Jr et al (2012) Transcatheter aortic valve implantation with a self-expanding nitinol bioprosthesis: prediction of the need for permanent pacemaker using simple baseline and procedural characteristics. Catheter Cardiovasc Interv 79:712–719

    Article  PubMed  Google Scholar 

  33. Schroeter T, Linke A, Haensig M, Merk DR, Borger MA, Mohr FW, Schuler G (2012) Predictors of permanent pacemaker implantation after Medtronic CoreValve bioprosthesis implantation. Europace 14:1759–1763

    Article  PubMed  Google Scholar 

  34. Houthuizen P, Van Garsse LA, Poels TT, de Jaegere P, van der Boon RM, Swinkels BM, Ten Berg JM, van der Kley F et al (2012) Left bundle-branch block induced by transcatheter aortic valve implantation increases risk of death. Circulation 126:720–728

    Article  PubMed  Google Scholar 

  35. van der Boon RM, Van Mieghem NM, Theuns DA, Nuis RJ, Nauta ST, Serruys PW, Jordaens L, van Domburg RT et al (2013) Pacemaker dependency after transcatheter aortic valve implantation with the self-expanding Medtronic CoreValve System. Int J Cardiol 168:1269–1273

    Article  PubMed  Google Scholar 

  36. Ferreira ND, Caeiro D, Adao L, Oliveira M, Goncalves H, Ribeiro J, Teixeira M, Albuquerque A et al (2010) Incidence and predictors of permanent pacemaker requirement after transcatheter aortic valve implantation with a self-expanding bioprosthesis. Pacing Clin Electrophysiol 33:1364–1372

    Article  PubMed  Google Scholar 

  37. Erkapic D, Kim WK, Weber M, Mollmann H, Berkowitsch A, Zaltsberg S, Pajitnev DJ, Rixe J et al (2010) Electrocardiographic and further predictors for permanent pacemaker requirement after transcatheter aortic valve implantation. Europace 12:1188–1190

    Article  PubMed  Google Scholar 

  38. Nijhoff F, Agostoni P, Amrane H, Latib A, Testa L, Oreglia JA, De Marco F, Samim M et al (2013) Transcatheter aortic valve implantation in patients with severe aortic valve stenosis and large aortic annulus, using the self-expanding 31-mm Medtronic CoreValve prosthesis: first clinical experience. J Thorac Cardiovasc Surg. doi:10.1016/j.jtcvs.2013.09.059

  39. Blackman DJ, Baxter PD, Gale CP, Moat NE, Maccarthy PA, Hildick-Smith D, Trivedi U, Cunningham D et al (2014) Do outcomes from transcatheter aortic valve implantation vary according to access route and valve type? The UK TAVI Registry. J Interv Cardiol 27:86–95

    Article  PubMed  Google Scholar 

  40. Kraus JDF, Hammerer M, Schneider J, Hoppe U, Strohmer B (2013) Pacemaker dependency after transaortic valve implantation. Osterreichische Kardiologische Gesellschaft Jahrestagung Wiener Med Wochenschr 125:s43–s43

  41. Bjerre Thygesen J, Loh PH, Cholteesupachai J, Franzen O, Sondergaard L (2014) Reevaluation of the indications for permanent pacemaker implantation after transcatheter aortic valve implantation. J Invasive Cardiol 26:94–99

    PubMed  Google Scholar 

  42. Gutierrez M, Rodes-Cabau J, Bagur R, Doyle D, DeLarochelliere R, Bergeron S, Lemieux J, Villeneuve J et al (2009) Electrocardiographic changes and clinical outcomes after transapical aortic valve implantation. Am Heart J 158:302–308

    Article  PubMed  Google Scholar 

  43. Laynez A, Ben-Dor I, Barbash IM, Hauville C, Sardi G, Maluenda G, Xue Z, Satler LF et al (2012) Frequency of conduction disturbances after Edwards SAPIEN percutaneous valve implantation. Am J Cardiol 110:1164–1168

    Article  PubMed  Google Scholar 

  44. Binder RK, Webb JG, Toggweiler S, Freeman M, Barbanti M, Willson AB, Alhassan D, Hague CJ et al (2013) Impact of post-implant SAPIEN XT geometry and position on conduction disturbances, hemodynamic performance, and paravalvular regurgitation. JACC Cardiovasc Interv 6:462–468

    Article  PubMed  Google Scholar 

  45. Urena M, Webb JG, Tamburino C, Munoz-Garcia AJ, Cheema A, Dager AE, Serra V, Amat-Santos IJ et al (2014) Permanent pacemaker implantation after transcatheter aortic valve implantation: impact on late clinical outcomes and left ventricular function. Circulation 129:1233–1243

    Article  PubMed  Google Scholar 

  46. Martinez-Selles M, Gomez Doblas JJ, Carro Hevia A, Garcia de la Villa B, Ferreira-Gonzalez I, Alonso Tello A, Andion Ogando R, Ripoll Vera T et al (2014) Prospective registry of symptomatic severe aortic stenosis in octogenarians: a need for intervention. J Intern Med 275:608–620

    Article  CAS  PubMed  Google Scholar 

  47. Jilaihawi H, Chakravarty T, Weiss RE, Fontana GP, Forrester J, Makkar RR (2012) Meta-analysis of complications in aortic valve replacement: comparison of Medtronic-Corevalve, Edwards-Sapien and surgical aortic valve replacement in 8,536 patients. Catheter Cardiovasc Interv 80:128–138

    Article  PubMed  Google Scholar 

  48. Fournial JF, Brodaty D, Chomette G, Tereau Y, Cabrol C, Acar J (1979) Conduction disorders after aortic valve replacement. Apropos of 200 cases. Arch Mal Coeur Vaiss 72:4–11

    CAS  PubMed  Google Scholar 

  49. Thomas JL, Dickstein RA, Parker FB Jr, Potts JL, Poirier RA, Fruehan CT, Eich RH (1982) Prognostic significance of the development of left bundle conduction defects following aortic valve replacement. J Thorac Cardiovasc Surg 84:382–386

    CAS  PubMed  Google Scholar 

  50. Kolh P, Kerzmann A, Honore C, Comte L, Limet R (2007) Aortic valve surgery in octogenarians: predictive factors for operative and long-term results. Eur J Cardiothorac Surg 31:600–606

    Article  PubMed  Google Scholar 

  51. Aktug O, Dohmen G, Brehmer K, Koos R, Altiok E, Deserno V, Herpertz R, Autschbach R et al (2012) Incidence and predictors of left bundle branch block after transcatheter aortic valve implantation. Int J Cardiol 160:26–30

    Article  PubMed  Google Scholar 

  52. Nuis RJ, Van Mieghem NM, Schultz CJ, Tzikas A, Van der Boon RM, Maugenest AM, Cheng J, Piazza N et al (2011) Timing and potential mechanisms of new conduction abnormalities during the implantation of the Medtronic CoreValve System in patients with aortic stenosis. Eur Heart J 32:2067–2074

    Article  PubMed  Google Scholar 

  53. Tzikas A, van Dalen BM, Van Mieghem NM, Gutierrez-Chico JL, Nuis RJ, Kauer F, Schultz C, Serruys PW et al (2011) Frequency of conduction abnormalities after transcatheter aortic valve implantation with the Medtronic-CoreValve and the effect on left ventricular ejection fraction. Am J Cardiol 107:285–289

    Article  PubMed  Google Scholar 

  54. Urena M, Mok M, Serra V, Dumont E, Nombela-Franco L, DeLarochelliere R, Doyle D, Igual A et al (2012) Predictive factors and long-term clinical consequences of persistent left bundle branch block following transcatheter aortic valve implantation with a balloon-expandable valve. J Am Coll Cardiol 60:1743–1752

    Article  PubMed  Google Scholar 

  55. Nazif TM, Williams MR, Hahn RT, Kapadia S, Babaliaros V, Rodes-Cabau J, Szeto WY, Jilaihawi H et al (2014) Clinical implications of new-onset left bundle branch block after transcatheter aortic valve replacement: analysis of the PARTNER experience. Eur Heart J 32:1599–1607

    Article  Google Scholar 

  56. Mukherjee C, Busse H, Mende M, Banusch J, Feussner M, Ender J (2013) Incidence and outcome of artioventricular block after transcatheter aortic valve implantation (TAVI): analysis in 994 patients. In: EACTA, pp 139–140

  57. Schwerg M, Baldenhofer G, Dreger H, Bondke H, Stangl K, Laule M, Melzer C (2013) Complete atrioventricular block after TAVI: when is pacemaker implantation safe? Pacing Clin Electrophysiol 36:898–903

    Article  PubMed  Google Scholar 

  58. Bagur R, Manazzoni JM, Dumont E, Doyle D, Perron J, Dagenais F, Mathieu P, Baillot R et al (2011) Permanent pacemaker implantation following isolated aortic valve replacement in a large cohort of elderly patients with severe aortic stenosis. Heart 97:1687–1694

    Article  PubMed  Google Scholar 

  59. Onorati F, D’Errigo P, Barbanti M, Rosato S, Covello DR, Maraschini A, Ranucci M, Grossi C et al (2013) Results differ between transaortic and open surgical aortic valve replacement in women. Ann Thorac Surg 96:1336–1342

    Article  PubMed  Google Scholar 

  60. Brignole M, Auricchio A, Baron-Esquivias G, Bordachar P, Boriani G, Breithardt OA, Cleland J, Deharo JC et al (2013) 2013 ESC guidelines on cardiac pacing and cardiac resynchronization therapy: the task force on cardiac pacing and resynchronization therapy of the European Society of Cardiology (ESC). Developed in collaboration with the European Heart Rhythm Association (EHRA). Europace 15:1070–1118

    Article  PubMed  Google Scholar 

  61. Ghadimi K, Patel PA, Gutsche JT, Sophocles A, Anwaruddin S, Szeto WY, Augoustides JG (2013) Perioperative conduction disturbances after transcatheter aortic valve replacement. J Cardiothorac Vasc Anesth 27:1414–1420

    Article  PubMed  Google Scholar 

  62. Anderson RH, Boyett MR, Dobrzynski H, Moorman AF (2013) The anatomy of the conduction system: implications for the clinical cardiologist. J Cardiovasc Transl Res 6:187–196

    Article  PubMed  Google Scholar 

  63. Moreno R, Dobarro D, Lopez de Sa E, Prieto M, Morales C, Calvo Orbe L, Moreno-Gomez I, Filgueiras D et al (2009) Cause of complete atrioventricular block after percutaneous aortic valve implantation: insights from a necropsy study. Circulation 120:e29–e30

    Article  PubMed  Google Scholar 

  64. Toutouzas K, Synetos A, Tousoulis D, Latsios G, Brili S, Mastrokostopoulos A, Karanasos A, Sideris S et al (2014) Predictors for permanent pacemaker implantation after core valve implantation in patients without preexisting ECG conduction disturbances: the role of a new echocardiographic index. Int J Cardiol 172:601–603

    Article  PubMed  Google Scholar 

  65. Tzamtzis S, Viquerat J, Yap J, Mullen MJ, Burriesci G (2013) Numerical analysis of the radial force produced by the Medtronic-CoreValve and Edwards-SAPIEN after transcatheter aortic valve implantation (TAVI). Med Eng Phys 35:125–130

    Article  CAS  PubMed  Google Scholar 

  66. Buellesfeld L, Stortecky S, Kalesan B, Gloekler S, Khattab AA, Nietlispach F, Delfine V, Huber C et al (2013) Aortic root dimensions among patients with severe aortic stenosis undergoing transcatheter aortic valve replacement. JACC Cardiovasc Interv 6:72–83

    Article  PubMed  Google Scholar 

  67. Breithardt G, Breithardt OA (2012) Left bundle branch block, an old-new entity. J Cardiovasc Transl Res 5:107–116

    Article  PubMed Central  PubMed  Google Scholar 

  68. Erkapic D, De Rosa S, Kelava A, Lehmann R, Fichtlscherer S, Hohnloser SH (2012) Risk for permanent pacemaker after transcatheter aortic valve implantation: a comprehensive analysis of the literature. J Cardiovasc Electrophysiol 23:391–397

    Article  PubMed  Google Scholar 

  69. Moat NE, Ludman P, de Belder MA, Bridgewater B, Cunningham AD, Young CP, Thomas M, Kovac J et al (2011) Long-term outcomes after transcatheter aortic valve implantation in high-risk patients with severe aortic stenosis: the U.K. TAVI (United Kingdom Transcatheter Aortic Valve Implantation) Registry. J Am Coll Cardiol 58:2130–2138

    Article  PubMed  Google Scholar 

  70. Elmariah S, Palacios IF, McAndrew T, Hueter I, Inglessis I, Baker JN, Kodali S, Leon MB et al (2013) Outcomes of transcatheter and surgical aortic valve replacement in high-risk patients with aortic stenosis and left ventricular dysfunction: results from the Placement of Aortic Transcatheter Valves (PARTNER) trial (cohort A). Circ Cardiovasc Interv 6:604–614

    Article  PubMed  Google Scholar 

  71. Hoffmann R, Herpertz R, Lotfipour S, Aktug O, Brehmer K, Lehmacher W, Autschbach R, Marx N et al (2012) Impact of a new conduction defect after transcatheter aortic valve implantation on left ventricular function. JACC Cardiovasc Interv 5:1257–1263

    Article  PubMed  Google Scholar 

  72. Khawaja MZ, Rajani R, Cook A, Khavandi A, Moynagh A, Chowdhary S, Spence MS, Brown S et al (2011) Permanent pacemaker insertion after CoreValve transcatheter aortic valve implantation: incidence and contributing factors (the UK CoreValve Collaborative). Circulation 123:951–960

    Article  CAS  PubMed  Google Scholar 

  73. Sinning JM, Werner N, Nickenig G, Grube E (2012) Next-generation transcatheter heart valves: current trials in Europe and the USA. Methodist Debakey Cardiovasc J 8:9–12

    Article  PubMed Central  PubMed  Google Scholar 

  74. Binder RK, Rodes-Cabau J, Wood DA, Mok M, Leipsic J, De Larochelliere R, Toggweiler S, Dumont E et al (2013) Transcatheter aortic valve replacement with the SAPIEN 3: a new balloon-expandable transcatheter heart valve. JACC Cardiovasc Interv 6:293–300

    Article  PubMed  Google Scholar 

  75. Falk V, Walther T, Schwammenthal E, Strauch J, Aicher D, Wahlers T, Schafers J, Linke A et al (2011) Transapical aortic valve implantation with a self-expanding anatomically oriented valve. Eur Heart J 32:878–887

    Article  CAS  PubMed  Google Scholar 

  76. Willson AB, Rodes-Cabau J, Wood DA, Leipsic J, Cheung A, Toggweiler S, Binder RK, Freeman M et al (2012) Transcatheter aortic valve replacement with the St. Jude Medical Portico valve: first-in-human experience. J Am Coll Cardiol 60:581–586

    Article  PubMed  Google Scholar 

  77. Treede H, Mohr FW, Baldus S, Rastan A, Ensminger S, Arnold M, Kempfert J, Figulla HR (2012) Transapical transcatheter aortic valve implantation using the JenaValve system: acute and 30-day results of the multicentre CE-mark study. Eur J Cardiothorac Surg 41:e131–e138

    Article  PubMed  Google Scholar 

  78. Schofer J, Schluter M, Treede H, Franzen OW, Tubler T, Pascotto A, Low RI, Bolling SF et al (2008) Retrograde transarterial implantation of a nonmetallic aortic valve prosthesis in high-surgical-risk patients with severe aortic stenosis: a first-in-man feasibility and safety study. Circ Cardiovasc Interv 1:126–133

    Article  PubMed  Google Scholar 

  79. Zembala MO, Piegza J, Waclawski J, Hawranek M, Hilker M, Niklewski T, Glowacki J, Parys M et al (2014) Symetis Acurate Transapical Aortic Valve: the initial experience with a second generation of transcatheter aortic valve replacement device. Kardiol Pol 72:187–193

    Article  PubMed  Google Scholar 

  80. Seiffert M, Conradi L, Kloth B, Koschyk D, Schirmer J, Schnabel RB, Blankenberg S, Reichenspurner H et al (2014) Single-centre experience with next-generation devices for transapical aortic valve implantation. Eur J Cardiothorac Surg [Epub ahead of print]

  81. Orlando R, Pennant M, Rooney S, Khogali S, Bayliss S, Hassan A, Moore D, Barton P (2013) Cost-effectiveness of transcatheter aortic valve implantation (TAVI) for aortic stenosis in patients who are high risk or contraindicated for surgery: a model-based economic evaluation. Health Technol Assess 17:1–86

    Article  CAS  PubMed  Google Scholar 

  82. Osman F, Krishnamoorthy S, Nadir A, Mullin P, Morley-Davies A, Creamer J (2010) Safety and cost-effectiveness of same day permanent pacemaker implantation. Am J Cardiol 106:383–385

    Article  PubMed  Google Scholar 

  83. Greenspon AJ, Patel JD, Lau E, Ochoa JA, Frisch DR, Ho RT, Pavri BB, Kurtz SM (2012) Trends in permanent pacemaker implantation in the United States from 1993 to 2009: increasing complexity of patients and procedures. J Am Coll Cardiol 60:1540–1545

    Article  PubMed  Google Scholar 

  84. Naber CTM, Bramlage P, Wasem J (2014) The impact of TAVI related permanent pacemaker implantation on the German healthcare system. Eurointervention 14A-OP319

Download references

Conflict of interest

MT is an employee of Edwards Lifesciences. The remaining authors are consultants or proctors.

Author information

Authors and Affiliations

  1. Cardiology Department, Hospital General Universitario Gregorio Marañón and Universidad Europea de Madrid, Madrid, Spain

    Manuel Martinez-Selles

  2. Institut für Pharmakologie und Präventive Medizin, Mahlow, Germany

    Peter Bramlage

  3. Leman Research Institute, Oberägeri, Switzerland

    Martin Thoenes

  4. Städtische Kliniken Karlsruhe, Karlsruhe, Germany

    Gerhard Schymik

Authors
  1. Manuel Martinez-Selles
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Peter Bramlage
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Martin Thoenes
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Gerhard Schymik
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Peter Bramlage.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Martinez-Selles, M., Bramlage, P., Thoenes, M. et al. Clinical significance of conduction disturbances after aortic valve intervention: current evidence. Clin Res Cardiol 104, 1–12 (2015). https://doi.org/10.1007/s00392-014-0739-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00392-014-0739-6

Keywords

Search

Navigation