Zusammenfassung
Jede Form der künstlichen Ernährung ist mit Komplikationen verbunden, die jedoch durch regelmäßige Effizienzkontrollen minimiert werden können. Bei kritisch Kranken kann die Einschätzung des Ernährungszustands sonographisch (Muskelmasse) oder mittels Subjective Global Assessment (SGA) erfolgen. Bei enteraler Ernährung ist die Aspiration eine gefürchtete Komplikation. Zur Minimierung des Risikos gehört die Überwachung der gastrointestinalen Motilität, die häufig gestört ist und dadurch eine bedarfsgerechte Ernährung verhindert wird. Daher muss die Menge der zugeführten bzw. mutmaßlich resorbierten Kalorien engmaschig überwacht werden. Unter parenteraler Ernährung können Hyperglykämien und Hypertriglyzeridämien exazerbieren; hier sind die Blutzucker- und Triglyzeridkonzentrationen engmaschig zu überwachen. Weiterhin kann sich eine Fettleber entwickeln, evt. in Verbindung mit biliären Komplikationen, welche sich durch Bestimmung der hepatischen Funktionsparameter im Plasma erkennen lassen. Patienten mit Nierenfunktionsstörungen bzw. ausgeprägten Volumenverschiebungen benötigen zusätzlich engmaschige Kontrollen der Elektrolytkonzentrationen, der Vitalfunktionen, des Hydratationszustandes sowie der Nierenfunktion.
Abstract
Independent from its type or mode, artificial nutrition may cause complications. In critical illness, it may be particularly difficult to evaluate the nutritional status of an individual patient. Accepting some degree of imprecision, muscle ultrasound and subjective global assessment may be valuable tools. During enteral nutrition, aspiration is the complication feared the most. To minimize corresponding risks, it is important to closely monitor gastrointestinal function which is likely to be impaired, thereby, often preventing the provision of sufficient calories. To account for potential deficits, a close monitoring of actually administered or presumably absorbed calories is essential. During parenteral nutrition, the risk is high that hyperglycemia or hypertriglyceridemia will exacerbate. Consequently, corresponding concentrations need to be closely monitored. Further complications include generation of a fatty liver, or biliary pathologies. The latter can be recognized by regularly determining plasmatic parameters of hepatic function. In patients with impaired kidney function or large volume shifts, close surveillance of electrolyte concentrations, vital function, hydration state, and kidney function is essential.
Literatur
Payne-James J (1997) Cost-effectiveness of nutrition support teams. Are they necessary? Nutrition 13:928–930
A.S.P.E.N Board of Directors (2001) Standards of practice: Nutrition support nurse. Nutr Clin Pract 16:56–62
Klein S, Kinney J, Jeejeebhoy K et al (1997) Nutrition support in clinical practice: review of published data and recommendations for future research directions. JPEN J Parenter Enteral Nutr 21:133–156
A.S.P.E.N Board of Directors (1996) Standards for nutrition support physicians. Nutr Clin Pract 11:235–240
Lochs H, Pichard C, Allison SP (2006) Evidence supports nutritional support. Clin Nutr 25:177–179
Darmon P, Lochs H, Pichard C (2008) Economic impact and quality of life as endpoints of nutritional therapy. Curr Opin Clin Nutr Metab Care 11(4):452–458
Bischoff SC, Kester L, Meier R et al (2009) Organisation, regulations, preparation and logistics of parenteral nutrition in hospitals and homes; the role of the nutrition support team – Guidelines on Parenteral Nutrition, Chapter 8. Ger Med Sci 7:Doc20
A.S.P.E.N Board of Directors and The Clinical Guidelines Task Force (2001) Guidelines for the use of parenteral and enteral nutrition in adult and pediatric patients. JPEN J Parenter Enteral Nutr 26:38SA–41SA
MacBurney M, Young LS, Ziegler TR, Wilmore DW (1994) A cost-evaluation of glutamine-supplemented parenteral nutrition in adult bone marrow transplant patients. J Am Diet Assoc 94:1263–1266
Senkal M, Zumtobel V, Bauer KH et al (1999) Outcome and cost-effectiveness of perioperative enteral immunonutrition in patients undergoing elective upper gastrointestinal tract surgery: a prospective randomized study. Arch Surg 134:1309–1316
Hedberg AM, Lairson DR, Aday LA et al (1999) Economic implications of an early postoperative enteral feeding protocol. J Am Diet Assoc 99:802–807
Boitano M, Bojak S, McCloskey S et al (2010) Improving the safety and effectiveness of parenteral nutrition: results of a quality improvement collaboration. Nutr Clin Pract 25(6):663–671
Trujillo EB, Young LS, Chertow GM et al (1999) Metabolic and monetary costs of avoidable parenteral nutrition use. JPEN J Parenter Enteral Nutr 23:109–113
Maurer J, Weinbaum F, Turner J et al (1996) Reducing the inappropriate use of parenteral nutrition in an acute care teaching hospital. JPEN J Parenter Enteral Nutr 20:272–274
Kennedy JF, Nightingale JM (2005) Cost savings of an adult hospital nutrition support team. Nutrition 21:1127–1133
Manning EM, Shenkin A (1995) Nutritional assessment in the critically ill. Crit Care Clin 11:603–634
Jeejeebhoy KN (2000) Nutritional assessment. Nutrition 16:585–590
Müller MJ, Bosy-Westphal A (2000) Körperzusammensetzung – Definition und Methoden. Akt Ernahr Med 25:60–63
Pirlich M, Schwenk A, Müller MJ (2003) Leitlinie enterale Ernährung: Ernährungsstatus. Akt Ernahr Med 28(Suppl 1):S10–S25
Ferreira LG, Anastácio LR, Lima AS, Correia MI (2010) Assessment of nutritional status of patients waiting for liver transplantation. Clin Transplant [Epub ahead of print]
Pirlich M, Plauth M, Lochs H (1999) Bioelektrische Impedanzanalyse: Fehlerquellen und methodische Grenzen bei der klinischen Anwendung zur Analyse der Körperzusammensetzung. Akt Ernahr Med 24:81–90
Norman K, Smoliner C, Kilbert A et al (2008) Disease-related malnutrition but not underweight by BMI is reflected by disturbed electric tissue properties in the bioelectrical impedance vector analysis. Br J Nutr 100(3):590–595
Van Venrooij LM, Verberne HJ, Vos R de et al (2010) Preoperative and postoperative agreement in fat free mass (FFM) between bioelectrical impedance spectroscopy (BIS) and dual-energy X-ray absorptiometry (DXA) in patients undergoing cardiac surgery. Clin Nutr 29(6):789–794
Campbell IT, Watt T, Withers D et al (1995) Muscle thickness, measured with ultrasound, may be an indicator of lean tissue wasting in multiple organ failure in the presence of edema. Am J Clin Nutr 62(3):533–539
Reid CL, Campbell IT, Little RA (2004) Muscle wasting and energy balance in critical illness. Clin Nutr 23(2):273–280
Gerovasili V, Stefanidis K, Vitzilaios K et al (2009) Electrical muscle stimulation preserves the muscle mass of critically ill patients: a randomized study. Crit Care 13(5):R161
Baker JP, Detsky AS, Wesson DE et al (1982) Nutritional assessment: a comparison of clinical judgement and objective measurements. N Engl J Med 306:969–972
Sheean PM, Peterson SJ, Gurka DP, Braunschweig CA (2010) Nutrition assessment: the reproducibility of subjective global assessment in patients requiring mechanical ventilation. Eur J Clin Nutr 64(11):1358–1364
Sungurtekin H, Sungurtekin U, Oner O, Okke D (2008–2009) Nutrition assessment in critically ill patients. Nutr Clin Pract 23(6):635–641
Atalay BG, Yagmur C, Nursal TZ et al (2008) Use of subjective global assessment and clinical outcomes in critically ill geriatric patients receiving nutrition support. JPEN J Parenter Enteral Nutr 32(4):454–459
Martindale RG, McClave SA, Vanek VW et al (2009) Guidelines for the provision and assessment of nutrition support therapy in the adult critically ill patient: Society of Critical Care Medicine and American Society for Parenteral and Enteral Nutrition: Executive Summary. Crit Care Med 37(5):1757–1761
Ukleja A (2010) Altered Gi Motility in Critically Ill Patients: Current Understanding of Pathophysiology, Clinical Impact, and Diagnostic Approach. Nutr Clin Pract 25:16–25
Fruhwald S, Holzer P, Metzler H (2008) Gastrointestinal motility in acute illness. Wien Klin Wochenschr 120:6–17
López-Herce J (2009) Gastrointestinal complications in critically Ill patients: what differs between adults and children? Curr Opin Clin Nutr Metab Care 12(2):180–185
Gomes GF, Pisani JC, Macedo ED, Campos AC (2003) The nasogastric feeding tube as a risk factor for aspiration and aspiration pneumonia. Curr Opin Clin Nutr Metab Care 6(3):327–333
McClave SA, DeMeo MT, DeLegge MH et al (2002) North American Summit on Aspiration in the Critically Ill Patient: consensus statement. JPEN J Parenter Enteral Nutr 26(6 Suppl):S80–S85
O’Keefe GE, Shelton M, Cuschieri J et al (2008) Inflammation and the host response to injury, a large-scale collaborative project: patient-oriented research core – standard operating procedures for clinical care VIII – Nutritional support of the trauma patient. J Trauma 65(6):1520–1528
Bankhead R, Boullata J, Brantley S et al (2009) Enteral nutrition practice recommendations. JPEN J Parenter Enteral Nutr 33(2):122–167
McClave SA, Snider HL, Lowen CC et al (1992) Use of residual volume as a marker for enteral feeding intolerance: prospective blinded comparison with physical examination and radiographic findings. JPEN J Parenter Enteral Nutr 16(2):99–105
Landzinski J, Kiser TH, Fish DN et al (2008) Gastric motility function in critically ill patients tolerant vs intolerant to gastric nutrition. JPEN J Parenter Enteral Nutr 32(1):45–50
Metheny NA, Stewart J, Nuetzel G et al (2005) Effect of feeding-tube properties on residual volume measurements in tube-fed patients. JPEN J Parenter Enteral Nutr 29(3):192–197
McClave SA, Snider HL (2002) Clinical use of gastric residual volumes as a monitor for patients on enteral tube feeding. JPEN J Parenter Enteral Nutr 26(6 Suppl):S43–S48
Heyland DK, Dhaliwal R, Drover JW et al (2003) Canadian clinical practice guidelines for nutrition support in mechanically ventilated, critically ill adult patients. JPEN J Parenter Enteral Nutr 27(5):355–373
Montejo JC, Miñambres E, Bordejé L et al (2010) Gastric residual volume during enteral nutrition in ICU patients: the REGANE study. Intensive Care Med 36(8):1386–1393
McClave SA, Lukan JK, Stefater JA et al (2005) Poor validity of residual volumes as a marker for risk of aspiration in critically ill patients. Crit Care Med 33(2):324–330
Pinilla JC, Samphire J, Arnold C et al (2001) Comparison of gastrointestinal tolerance to two enteral feeding protocols in critically ill patients: a prospective, randomized controlled trial. JPEN J Parenter Enteral Nutr 25(2):81–86
Desachy A, Clavel M, Vuagnat A et al (2008) Initial efficacy and tolerability of early enteral nutrition with immediate or gradual introduction in intubated patients. Intensive Care Med 34(6):1054–1059
Metheny NA, Schallom L, Oliver DA, Clouse RE (2008) Gastric residual volume and aspiration in critically ill patients receiving gastric feedings. Am J Crit Care 17(6):512–519
Elpern EH, Stutz L, Peterson S et al (2004) Outcomes associated with enteral tube feedings in a medical intensive care unit. Am J Crit Care 13(3):221–227
Umbrello M, Elia G, Destrebecq AL, Iapichino G (2009) Tolerance of enteral feeding: from quantity to quality of gastric residual volume? Intensive Care Med 35(9):1651–1652
Mentec H, Dupont H, Bocchetti M et al (2001) Upper digestive intolerance during enteral nutrition in critically ill patients: frequency, risk factors, and complications. Crit Care Med 29(10):1955–1961
Metheny NA, Clouse RE, Chang YH et al (2006) Tracheobronchial aspiration of gastric contents in critically ill tube-fed patients: frequency, outcomes, and risk factors. Crit Care Med 34(4):1007–1015
Poulard F, Dimet J, Martin-Lefevre L et al (2010) Impact of not measuring residual gastric volume in mechanically ventilated patients receiving early enteral feeding: a prospective before-after study. JPEN J Parenter Enteral Nutr 34(2):125–130
Jeejeebhoy KN (2001) Total parenteral nutrition: potion or poison? Am J Clin Nutr 74:160–163
Lekka ME, Liokatis S, Nathanail C et al (2004) The impact of intravenous fat emulsion administration in acute lung injury. Am J Respir Crit Care Med 169:638–4
Tripathy D, Mohanty P, Dhindsa S et al (2003) Elevation of free fatty acids induces inflammation and impairs vascular reactivity in healthy subjects. Diabetes 52:2882–2887
Llop J et al (2003) The importance of clinical factors in parenteral nutrition-associated hypertriglyceridemia. Clin Nutr 22:577–583
Hermansen K, Dinesen B, Hoie LH et al (2003) Effects of soy and other natural products on LDL:HDL ratio and other lipid parameters: a literature review. Adv Ther 20:50–78
Gura K, Strijbosch R, Arnold S et al (2007) The role of an intravenous fat emulsion composed of fish oil in a parenteral nutrition-dependent patient with hypertriglyceridemia. Nutr Clin Pract 22(6):664–672
Suchner U, Katz DP, Furst P et al (2001) Effects of intravenous fat emulsions on lung function in patients with acute respiratory distress syndrome or sepsis. Crit Care Med 29:1569–1574
Smyrniotis VE, Kostopanagiotou GG, Arkadopoulos NF et al (2001) Long-chain versus medium-chain lipids in acute pancreatitis complicated by acute respiratory distress syndrome: effects on pulmonary hemodynamics and gas exchange. Clin Nutr 20:139–143
Waitzberg DL, Lotierzo PH, Logullo AF et al (2002) Parenteral lipid emulsions and phagocytic systems. Br J Nutr 87(Suppl 1):S49–S57
Calder PC (2003) Long-chain n-3 fatty acids and inflammation: potential application in surgical and trauma patients. Braz J Med Biol Res 36:433–446
Mayer K, Fegbeutel C, Hattar K et al (2003) Omega-3 vs. omega-6 lipid emulsions exert differential influence on neutrophils in septic shock patients: impact on plasma fatty acids and lipid mediator generation. Intensive Care Med 29:1472–1481
Tsuang W, Navaneethan U, Ruiz L et al (2009) Hypertriglyceridemic pancreatitis: presentation and management. Am J Gastroenterol 104(4):984–991
Ewald N, Hardt PD, Kloer HU (2009) Severe hypertriglyceridemia and pancreatitis: presentation and management. Curr Opin Lipidol 20(6):497–504
Hartl W, Jauch KW, Parhofer K, Rittler P (2007) Komplikationen und Monitoring. Akt Ernähr Med 32(Suppl 1):S60–S68
Alberti KG, Zimmet P, Shaw J, IDF Epidemiology Task Force Consensus Group (2005) The metabolic syndrome – a new worldwide definition. Lancet 366(9491):1059–1062
Grundy SM, Brewer HB Jr, Cleeman JI et al (2004) Definition of metabolic syndrome: Report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition. Circulation 109(3):433–438
Rydén L, Standl E, Bartnik M et al (2007) Guidelines on diabetes, pre-diabetes, and cardiovascular diseases: executive summary. The Task Force on Diabetes and Cardiovascular Diseases of the European Society of Cardiology (ESC) and of the European Association for the Study of Diabetes (EASD). Eur Heart J 28(1):88–136
Van den Berghe G, Wouters P, Weekers F et al (2001) Intensive insulin therapy in the critically ill patients. N Engl J Med 345(19):1359–1367
Mesotten D, Swinnen JV, Vanderhoydonc F et al (2004) Contribution of circulating lipids to the improved outcome of critical illness by glycemic control with intensive insulin therapy. J Clin Endocrinol Metab 89(1):219–226
Schetz M, Vanhorebeek I, Wouters PJ et al (2008) Tight blood glucose control is renoprotective in critically ill patients. J Am Soc Nephrol 19(3):571–578
Mirtallo JM, Dasta JF, Kleinschmidt KC, Varon J (2010) State of the art review: Intravenous fat emulsions: Current applications, safety profile, and clinical implications. Ann Pharmacother 44(4):688–700
Finney SJ, Zekveld C, Elia A, Evans TW (2003) Glucose control and mortality in critically ill patients. JAMA 290:2041–2047
Malmberg K (1997) Prospective randomised study of intensive insulin treatment on long term survival after acute myocardial infarction in patients with diabetes mellitus. BMJ 314:1512
Meier JJ et al (2002) Einfluss einer eingeschränkten Glukosetoleranz auf das Langzeitüberleben nach akutem Myokardinfarkt. DMW 127:1123–1129
Norhammer AM et al (1999) Admission plasma glucose. Independent risk factor for long-term prognosis after myocardial infarction even in nondiabetic patients. Diabetes Care 22:1827–1831
Parsons MW et al (2002) Acute hyperglycemia adversely affects stroke outcome: a magnetic resonance imaging and spectroscopy study. Ann Neurol 52:20–28
Umpierrez GE et al (2002) Hyperglycemia: an independent marker of in-hospital mortality in patients with undiagnosed diabetes. J Clin Endocrin Metab 87:978–982
Weir CJ et al (1997) Is hyperglycaemia an independent predictor or poor outcome after acute stroke? Results of a long term follow up study. BMJ 314:1303
Zindrou D et al (2001) Admission Plasma glucose. An independent risk factor in nondiabetic women after coronary artery bypass grafting. Diabetes Care 24:1634–1639
Rosmarin DK, Wardlaw GM, Mirtallo J (1996) Hyperglycemia associated with high, continuous infusion rates of total parenteral nutrition dextrose. Nutr Clin Pract 11:151–156
Kaminski MV Jr (1978) A review of hypersomolar hyperglycemic nonketotic dehydration (HHND): etiology, pathophysiology and prevention during intravenous hyperalimentation. JPEN J Parenter Enteral Nutr 2:690–698
Van den Berghe G (2003) Insulin therapy for the critically ill patient. Clin Cornerstone 5:56–63
Mizock BA (2003) Blood glucose management during critical illness. Rev Endocr Metab Disord 4:187–194
Zoungas S, Patel A, Chalmers J et al (2010) Severe hypoglycemia and risks of vascular events and death. N Engl J Med 363(15):1410–1418
Van den Berghe G, Wilmer A, Hermans G et al (2006) Intensive insulin therapy in the medical ICU. N Engl J Med 354(5):449–461
Vlasselaers D, Milants I, Desmet L et al (2009) Intensive insulin therapy for patients in paediatric intensive care: a prospective, randomised controlled study. Lancet 373(9663):547–556
Wiener RS, Wiener DC, Larson RJ (2008) Benefits and risks of tight glucose control in critically ill adults: a meta-analysis. JAMA 300(8):933–944
Griesdale DE, Souza RJ de, Dam RM van et al (2009) Intensive insulin therapy and mortality among critically ill patients: a meta-analysis including NICE-SUGAR study data. CMAJ 180(8):821–827
Marik PE, Preiser JC (2010) Toward understanding tight glycemic control in the ICU: a systematic review and metaanalysis. Chest 137(3):544–551
Hermans G, Schetz M, Berghe G van den (2008) Tight glucose control in critically ill adults. JAMA 300(23):2725
Gunst J, Van den Berghe G (2010) Blood glucose control in the intensive care unit: benefits and risks. Semin Dial 23(2):157–162
Van den Berghe G, Mesotten D, Vanhorebeek I (2009) Intensive insulin therapy in the intensive care unit. CMAJ 180(8):799–800
NICE-SUGAR Study Investigators, Finfer S, Chittock DR et al (2009) Intensive versus conventional glucose control in critically ill patients. N Engl J Med 360(13):1283–1297
Adamkin DH (2003) Total parenteral nutrition-associated cholestasis: prematurity or amino acids? J Perinatol 23:437–438
Chung C, Buchman AL (2002) Postoperative jaundice and total parenteral nutrition-associated hepatic dysfunction. Clin Liver Dis 6:1067–1084
Angelico M, Guardia D (2000) Hepatobiliary complications associated with total parenteral nutrition. Alim Pharmacol Ther 14:54–57
Forchielli ML, Walker WA (2003) Nutritional factors contributing to the development of cholestasis during total parenteral nutrition. Adv Pediatr 50:245–267
Sandhu I et al (1999) Total parenteral nutrition and cholestasis. Clin Liv Dis 3:489–508
De Meijer VE, Gura KM, Meisel JA et al (2010) Parenteral fish oil monotherapy in the management of patients with parenteral nutrition-associated liver disease. Arch Surg 145(6):547–551
Buchman AL (2001) Complications of long-term home total parenteral nutrition. Dig Dis Sci 46:1–18
Owens JP, Geibig CB, Mirtallo JM (1989) Concurrent quality assurance for a nutrition-support service. Am J Hosp Pharm 46:2469–2476
Grünert A, Anhang A (1990) Überwachung der Patienten mit Ernährungstherapie – Biophysikalische und biochemische Meßgrößen. Klin Anasthesiol Intensivther 40:193–195
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Hartl, W., Kuppinger, D. Monitoring der künstlichen Ernährung bei kritisch kranken Patienten. Intensivmed 48, 99–108 (2011). https://doi.org/10.1007/s00390-010-0220-3
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DOI: https://doi.org/10.1007/s00390-010-0220-3