Skip to main content

Advertisement

SpringerLink
Log in

A case of alpha-fetoprotein-producing gastric cancer in a child presenting with rupture of multiple liver metastases

  • Case Report
  • Published:
Pediatric Surgery International Aims and scope Submit manuscript

Abstract

We report a 14-year-old boy with alpha-fetoprotein-producing gastric cancer (AFPGC) who was found with ruptured metastatic tumor in the liver. AFPGC is exceedingly rare in pediatric age. It often shows metastases to the liver and should be included in differential diagnoses of liver tumors with increased serum AFP.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

References

  1. Liu X, Cheng Y, Sheng W, Lu H, Xu Y, Long Z, Zhu H, Wang Y (2010) Clinicopathologic features and prognostic factors in alpha-fetoprotein-producing gastric cancers: analysis of 104 cases. J Surg Oncol 102(3):249–255. doi:10.1002/jso.21624

    Article  PubMed  Google Scholar 

  2. Emir S, Karakurt N, Karakus E, Senel E, Kirsaclioglu C, Demir HA, Orhan D (2014) Alpha-fetoprotein-producing hepatoid gastric adenocarcinoma in a child presenting with spontaneous gastric perforation. Turk J Pediatr 56(1):88–91

    PubMed  Google Scholar 

  3. Subbiah V, Varadhachary G, Herzog CE, Huh WW (2011) Gastric adenocarcinoma in children and adolescents. Pediatr Blood Cancer 57(3):524–527. doi:10.1002/pbc.23051

    Article  PubMed Central  PubMed  Google Scholar 

  4. Curtis JL, Burns RC, Wang L, Mahour GH, Ford HR (2008) Primary gastric tumors of infancy and childhood: 54-year experience at a single institution. J Pediatr Surg 43(8):1487–1493. doi:10.1016/j.jpedsurg.2007.11.016

    Article  PubMed  Google Scholar 

  5. McGill TW, Downey EC, Westbrook J, Wade D, de la Garza J (1993) Gastric carcinoma in children. J Pediatr Surg 28(12):1620–1621

    Article  CAS  PubMed  Google Scholar 

  6. Nakamura T, Yao T, Niho Y, Tsuneyoshi M (1999) A clinicopathological study in young patients with gastric carcinoma. J Surg Oncol 71(4):214–219

    Article  CAS  PubMed  Google Scholar 

  7. Harting MT, Blakely ML, Herzog CE, Lally KP, Ajani JA, Andrassy RJ (2004) Treatment issues in pediatric gastric adenocarcinoma. J Pediatr Surg 39(8):e8–e10

    Article  PubMed  Google Scholar 

  8. Uozaki H, Fukayama M (2008) Epstein-Barr virus and gastric carcinoma–viral carcinogenesis through epigenetic mechanisms. Int J Clin Exp Pathol 1(3):198–216

    PubMed Central  CAS  PubMed  Google Scholar 

  9. Woo DK, Kim HS, Lee HS, Kang YH, Yang HK, Kim WH (2001) Altered expression and mutation of beta-catenin gene in gastric carcinomas and cell lines. Int J Cancer 95(2):108–113

    Article  CAS  PubMed  Google Scholar 

  10. Zhou YN, Xu CP, Han B, Li M, Qiao L, Fang DC, Yang JM (2002) Expression of E-cadherin and beta-catenin in gastric carcinoma and its correlation with the clinicopathological features and patient survival. World J Gastroenterol 8(6):987–993

    CAS  PubMed  Google Scholar 

  11. Michálek J, Kopecná L, Tůma J, Hrstková H, Feit J (2000) Gastric carcinoma in a 9-year-old boy. Pediatr Hematol Oncol 17(6):511–515. doi:10.1080/08880010050120881

    Article  PubMed  Google Scholar 

  12. Chiba N, Yoshioka T, Sakayori M, Mikami Y, Miyazaki S, Akiyama S, Otsuka K, Yamaura G, Shibata H, Kato S, Kato S, Ishioka C (2005) AFP-producing hepatoid adenocarcinoma in association with Barrett’s esophagus with multiple liver metastasis responding to paclitaxel/CDDP: a case report. Anticancer Res 25(4):2965–2968

    PubMed  Google Scholar 

  13. Furuya Y, Wakahara T, Akimoto H, Kishimoto T, Hiroshima K, Yanagie H, Yasuhara H (2011) Clear cell adenocarcinoma with enteroblastic differentiation of the ascending colon. J Clin Oncol 29(22):e647–e649. doi:10.1200/jco.2011.34.9670

    Article  PubMed  Google Scholar 

Download references

Conflict of interest

The authors declare that they have no conflict of interest.

Author information

Authors and Affiliations

  1. Department of Pathology, Kanagawa Children’s Medical Center, Mutsukawa, 2-138-4, Minami-ku, Yokohama, Kanagawa, 232-8555, Japan

    Eriko Takeyama, Mio Tanaka & Yukichi Tanaka

  2. Department of Pediatric Surgery, The University of Tokyo, Tokyo, Japan

    Eriko Takeyama, Jun Fujishiro & Tadashi Iwanaka

  3. Department of Surgery, Kanagawa Children’s Medical Center, Yokohama, Japan

    Norihiko Kitagawa

Authors
  1. Eriko Takeyama
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Mio Tanaka
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Jun Fujishiro
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Norihiko Kitagawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Tadashi Iwanaka
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Yukichi Tanaka
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Eriko Takeyama.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Takeyama, E., Tanaka, M., Fujishiro, J. et al. A case of alpha-fetoprotein-producing gastric cancer in a child presenting with rupture of multiple liver metastases. Pediatr Surg Int 31, 885–888 (2015). https://doi.org/10.1007/s00383-015-3724-x

Download citation

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00383-015-3724-x

Keywords

Search

Navigation