Abstract
Purpose
We have evaluated the clinical, radiological and metabolic features of infantile urolithiasis (UL).
Materials and methods
We have reviewed the medical records of 93 children who were diagnosed as having UL before 1 year of age. We recorded patient demographics, the age at diagnosis, presenting symptoms, family history, the localizations and dimensions of stones, urinary metabolic examinations, as well as physical, laboratory, and radiologic findings. Our secondary objective was to compare some features of this group with those of older children with UL followed-up in the same clinic which were previously reported.
Results
We evaluated 93 children referred to our pediatric nephrology clinics. A family history of UL was 56.2 % in the study group. Resolution of stones was observed in 30.1 % of the cases. Urinary tract infections (UTIs) were detected in 65.9 % of females and 46.2 % of males. At least one urinary metabolic abnormality was found in 79.5 % of all the children. Most commonly seen metabolic abnormality was hypercalciuria. In all patients stones were located in kidneys except one infant who had an ureteral stone together with a kidney stone. Fifteen (16.1 %) children had an accompanying systemic disorder.
Conclusions
Among pediatric urinary stone diseases infantile UL can be regarded as a separate clinical entity. Coexistence of systemic disorders and anatomic anomalies at high frequencies may indicate a role of distinct pathogenetic mechanisms. In addition, high rates of UTIs and metabolic abnormalities in this age group justify screening for these parameters during follow-up of these children.
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References
Ali SH, Rifat UN (2005) Etiological and clinical patterns of childhood urolithiasis in Iraq. Pediatr Nephrol 20(10):1453–1457
Coward RJ, Peters CJ, Duffy PG, Corry D, Kellett MJ, Choong S, van’t Hoff WG (2003) Epidemiology of paediatric renal stone disease in the UK. Arch Dis Child 88(11):962–965
Dursun I, Poyrazoglu HM, Dusunsel R, Gunduz Z, Gurgoze MK, Demirci D, Kucukaydin M (2008) Pediatric urolithiasis: an 8-year experience of single centre. Int Urol Nephrol 40(1):3–9
Mohamed J, Riadh M, Abdellatif N (2007) Urolithiasis in infants. Pediatr Surg Int 23(4):295–299
Lottman H, Archambault F, Traxer O (2000) Mercier Pageyral B, Hellal B. The efficacy and parenchymal consequences of extracorporeal shock wave lithotripsy in infant. Br J Urol 85:311–315
Rhodes C, Churchill D, Hulton SA (2005) Antenatal diagnosis of fetal renal calculus. Ultrasound Obstet Gynecol 25:517–518
Tannous RJ, Solhaug MJ, Bogdan D, Abuhamed AZ (2000) Prenatal diagnosis of fetal nephrolithiasis. Ultrasound Obstet Gynecol 15:331–332
Polito C, Cioce F, La Manna A, Maiello R, Di Toro R (1999) Renal calyceal microlithiasis: clinical presentation may precede sonographic evidence. Clin Pediatr (Phila) 38(9):521–524
Ghazali S, Barratt TM (1974) Urinary excretion of calcium and magnesium in children. Arch Dis Child 49(2):97–101
Hoppe B, Leumann E, Milliner DS (2008) Urolithiasis and nephrocalcinosis in childhood. In: Geary DF, Schaefer F (eds) Comprehensive pediatric nephrology, 1st edn. Mosby, Philadelphia, pp 499–526
Srivastava T, Alon US (2005) Urolithiasis in adolescent children. Adolesc Med Clin 16(1):87–109
Milliner DS (2004) Urolithiasis. In: Avner ED, Harman WE, Niaudet P (eds) Pediatric nephrology, 5th edn. Lippincott Williams & Wilkins, Philadelphia, pp 1091–1112
Bartosh SM (2004) Medical management of pediatric stone disease. Urol Clin North Am 31(3):575–587
Alpay H, Ozen A, Gokce I, Biyikli N (2009) Clinical and metabolic features of urolithiasis and microlithiasis in children. Pediatr Nephrol 24:2203–2209
Perrone HC, dos Santos DR, Santos MV, Pinheiro ME, Toporovski J, Ramos OL, Schor N (1992) Urolithiasis in childhood: metabolic evaluation. Pediatr Nephrol 6:54–56
Milliner DS, Murphy ME (1993) Urolithiasis in pediatric patients. Mayo Clin Proc 68:241–248
Lim DJ, Walker RD 3rd, Ellsworth PI, Newman RC, Cohen MS, Barraza MA, Stevens PS (1996) Treatment of pediatric urolithiasis between 1984 and 1994. J Urol 156:702–705
Pietrow PK, Pope JC 4th, Adams MC, Shyr Y, Brock JW 3rd (2002) Clinical outcome of pediatric stone disease. J Urol 167:670–673
Santos-Victoriano M, Brouhard BH, Cunningham RJ 3rd (1998) Renal stone disease in children. Clin Pediatr (Phila) 37(10):583–599
Begun FP, Foley WD, Peterson A, White B (1997) Patient evaluation. Laboratory and imaging studies. Urol Clin North Am 24(1):97–116
Bihl G, Meyers A (2001) Recurrent renal stone disease-advances in pathogenesis and clinical management. Lancet 358(9282):651–656
Tekin A, Tekgul S, Atsu N, Bakkaloglu M, Kendi S (2002) Oral potassium citrate treatment for idiopathic hypocitruria in children with calcium urolithiasis. J Urol 168(6):2572–2574
Lee H, Han SW, Hong CH, Koo G (2008) Clinical outcome of infantile renal calcification. J Pediatr Urol 4(Suppl 1):S22
Bakane BC, Nagtilak SB, Patil B (1999) Urolithiasis: a tribal scenario. Indian J Pediatr 66:863
Buck CA (1993) The epidemiology, formation, composition and medical management of idiopathic stone disease. Curr Opin Urol 3:316
Rizvi SA, Naqvi SA, Hussain Z, Hashmi A, Hussain M, Zafar MN, Sultan S, Mehdi H (2002) Pediatric urolithiasis: developing nation perspectives. J Urol 168:1522–1525
Ozokutan BH, Kucukaydin M, Gunduz Z, Kabaklioglu M, Okur H, Turan C (2000) Urolithiasis in childhood. Pediatr Surg Int 16:60–63
Eckstein HB (1961) Endemic urinary lithiasis in Turkish children. Arch Dis Child 36:137–144
Erbagcı A, Erbagcı AB, Yılmaz M, Yagci F, Tarakcioglu M, Yurtseven C, Koyluoglu O, Sarica K (2003) Pediatric urolithiasis. Evaluation of risk factors in 95 children. Scand J Urol Nephrol 37:129–133
Sternberg K, Greenfield SP, Williot P, Wan J (2005) Pediatric stone disease: an evolving experience. J Urol 174:1711–1714
Baysal YE, Koyun M, Akman S, Güven AG, Güntekin E (2004) Çocuklarda ürolitiyazis: Antalya yöresinde 10 yıllık deneyim. Çocuk Sağlığı ve Hastalıkları Dergisi 47:254–259
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Alpay, H., Gokce, I., Özen, A. et al. Urinary stone disease in the first year of life: is it dangerous?. Pediatr Surg Int 29, 311–316 (2013). https://doi.org/10.1007/s00383-012-3235-y
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DOI: https://doi.org/10.1007/s00383-012-3235-y