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A case of relapsing spinal atypical teratoid/rhabdoid tumor (AT/RT) responding to vinorelbine, cyclophosphamide, and celecoxib

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Abstract

Introduction:

Atypical teratoid/rhabdoid tumor (AT/RT) of the central nervous system is a highly aggressive neoplasm which prevalently affects children and is characterized by a severe prognosis.

Case presentation:

The authors describe an extremely rare case of a primary spinal AT/RT that occurred in a young girl. The patient underwent a wide surgical resection of a lumbar mass, followed by aggressive chemotherapy, myeloablative treatment, and local radiotherapy. After 7 months from the end of the treatment, the patient experienced local recurrence and was treated with surgery and second-line chemotherapy with antiangiogenic purposes, consisting of oral vinorelbine, cyclophosphamide, and celecoxib. Treatment was well tolerated, and patient was still alive 36 months after diagnosis.

Conclusion:

The peculiarity of this case report is the clinical-radiological response to a metronomic therapy in a case of early-relapsing spinal AT/RT despite previous maximal surgery, chemotherapy, and radiotherapy.

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Conflict of interest

The authors declare no conflicts of interest.

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Authors and Affiliations

  1. Pediatric Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy

    Giacomo Gotti, Veronica Biassoni, Elisabetta Schiavello, Filippo Spreafico & Maura Massimino

  2. Department of Pathology, Sapienza University, Policlinico Umberto I, Rome, Italy

    Manila Antonelli

  3. Department of Radiology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy

    Giuseppina Calareso

  4. Department of Radiotherapy, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy

    Emilia Pecori & Lorenza Gandola

Authors
  1. Giacomo Gotti
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  2. Veronica Biassoni
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  3. Elisabetta Schiavello
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  4. Filippo Spreafico
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  5. Manila Antonelli
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  6. Giuseppina Calareso
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  7. Emilia Pecori
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  8. Lorenza Gandola
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  9. Maura Massimino
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Corresponding author

Correspondence to Giacomo Gotti.

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Gotti, G., Biassoni, V., Schiavello, E. et al. A case of relapsing spinal atypical teratoid/rhabdoid tumor (AT/RT) responding to vinorelbine, cyclophosphamide, and celecoxib. Childs Nerv Syst 31, 1621–1623 (2015). https://doi.org/10.1007/s00381-015-2755-x

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  • DOI: https://doi.org/10.1007/s00381-015-2755-x

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