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L5 spondylolysis/spondylolisthesis: a comprehensive review with an anatomic focus

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Abstract

Introduction

Spondylolysis is most commonly observed in the lumbar spine, particularly L5, and is associated with spondylolisthesis, or anterior “slippage” of a vertebra in relation to an adjacent vertebra. Isthmic spondylolisthesis is the result of a pars interarticularis defect and will be the only type of spondylolisthesis addressed in this review.

Conclusions

Spondylolysis and spondylolisthesis represent a relatively common cause of low back pain, especially in young athletes, and a less common cause of neurologic compromise. When discovered in a symptomatic patient with corroborating imaging findings, early intervention provides an excellent prognosis. Herein, we review the anatomy and pathology of spondylosis and spondylolisthesis of the L5 vertebra.

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References

  1. Albanese M, Pizzutillo PD (1982) Family study of spondylolysis and spondylolisthesis. J Pediatr Orthop 2:496–499

    Article  PubMed  CAS  Google Scholar 

  2. Amato M, Totty WG, Gilula LA (1984) Spondylolysis of the lumbar spine: demonstration of defects and laminal fragmentation. Radiology 153:627–629

    PubMed  CAS  Google Scholar 

  3. Belfi LM, Ortiz AO, Katz DS (2006) Computed tomography evaluation of spondylolysis and spondylolisthesis in asymptomatic patients. Spine (Phila Pa 1976) 31:E907–E910

    Article  Google Scholar 

  4. Bellah RD, Summerville DA, Treves ST, Micheli LJ (1991) Low-back pain in adolescent athletes: detection of stress injury to the pars interarticularis with SPECT. Radiology 180:509–512

    PubMed  CAS  Google Scholar 

  5. Beutler WJ, Fredrickson BE, Murtland A, Sweeney CA, Grant WD, Baker D (2003) The natural history of spondylolysis and spondylolisthesis: 45-year follow-up evaluation. Spine (Phila Pa 1976) 28:1027–1035, discussion 1035

    Google Scholar 

  6. Birch JG, Herring JA, Maravilla KR (1986) Splitting of the intervertebral disc in spondylolisthesis: a magnetic resonance imaging finding in two cases. J Pediatr Orthop 6:609–611

    Article  PubMed  CAS  Google Scholar 

  7. Carpener NC (1932) Spondylolithesis. Br J Surg 19:374–386

    Article  Google Scholar 

  8. Collier BD, Johnson RP, Carrera GF, Meyer GA, Schwab JP, Flatley TJ, Isitman AT, Hellman RS, Zielonka JS, Knobel J (1985) Painful spondylolysis or spondylolisthesis studied by radiography and single-photon emission computed tomography. Radiology 154:207–211

    PubMed  CAS  Google Scholar 

  9. Dubousset J (1997) Treatment of spondylolysis and spondylolisthesis in children and adolescents. Clin Orthop Relat Res: 77–85

  10. Dunn AJ, Campbell RS, Mayor PE, Rees D (2008) Radiological findings and healing patterns of incomplete stress fractures of the pars interarticularis. Skeletal Radiol 37:443–450

    Article  PubMed  Google Scholar 

  11. Elliott S, Hutson MA, Wastie ML (1988) Bone scintigraphy in the assessment of spondylolysis in patients attending a sports injury clinic. Clin Radiol 39:269–272

    PubMed  CAS  Google Scholar 

  12. Farfan HF, Osteria V, Lamy C (1976) The mechanical etiology of spondylolysis and spondylolisthesis. Clin Orthop Relat Res: 40–55

  13. Fredrickson BE, Baker D, McHolick WJ, Yuan HA, Lubicky JP (1984) The natural history of spondylolysis and spondylolisthesis. J Bone Joint Surg 66:699–707

    PubMed  CAS  Google Scholar 

  14. Frennered AK, Danielson BI, Nachemson AL, Nordwall AB (1991) Midterm follow-up of young patients fused in situ for spondylolisthesis. Spine (Phila Pa 1976) 16:409–416

    Article  CAS  Google Scholar 

  15. Goldstein JD, Berger PE, Windler GE, Jackson DW (1991) Spine injuries in gymnasts and swimmers. An epidemiologic investigation. Am J Sports Med 19:463–468

    Article  PubMed  CAS  Google Scholar 

  16. Harvey CJ, Richenberg JL, Saifuddin A, Wolman RL (1998) The radiological investigation of lumbar spondylolysis. Clin Radiol 53:723–728

    Article  PubMed  CAS  Google Scholar 

  17. Helenius I, Lamberg T, Osterman K, Schlenzka D, Yrjonen T, Tervahartiala P, Seitsalo S, Poussa M, Remes V (2005) Scoliosis research society outcome instrument in evaluation of long-term surgical results in spondylolysis and low-grade isthmic spondylolisthesis in young patients. Spine (Phila Pa 1976) 30:336–341

    Article  Google Scholar 

  18. Hensinger RN, Lang JR, MacEwen GD (1976) Surgical management of spondylolisthesis in children. Spine 1:207–217

    Article  Google Scholar 

  19. Hensinger RN (1989) Spondylolysis and spondylolisthesis in children and adolescents. J Bone Joint Surg Br 71:1098–1107

    CAS  Google Scholar 

  20. Hollenberg GM, Beattie PF, Meyers SP, Weinberg EP, Adams MJ (2002) Stress reactions of the lumbar pars interarticularis: the development of a new MRI classification system. Spine (Phila Pa 1976) 27:181–186

    Article  Google Scholar 

  21. Hu SS, Tribus CB, Diab M, Ghanayem AJ (2008) Spondylolisthesis and spondylolysis. J Bone Joint Surg Am 90:656–671

    PubMed  Google Scholar 

  22. Huang RP, Bohlman HH, Thompson GH, Poe-Kochert C (2003) Predictive value of pelvic incidence in progression of spondylolisthesis. Spine (Phila Pa 1976) 28:2381–2385, discussion 2385

    Article  Google Scholar 

  23. Jackson DW, Wiltse LL, Dingeman RD, Hayes M (1981) Stress reactions involving the pars interarticularis in young athletes. Am J Sports Med 9:304–312

    Article  PubMed  CAS  Google Scholar 

  24. Johnson DW, Farnum GN, Latchaw RE, Erba SM (1989) MR imaging of the pars interarticularis. AJR Am J Roentgenol 152:327–332

    PubMed  CAS  Google Scholar 

  25. Kalichman L, Kim DH, Li L, Guermazi A, Berkin V, Hunter DJ (2009) Spondylolysis and spondylolisthesis: prevalence and association with low back pain in the adult community-based population. Spine (Phila Pa 1976) 34:199–205

    Article  Google Scholar 

  26. Kim HJ, Green DW (2008) Adolescent back pain. Curr Opin Pediatr 20:37–45

    Article  PubMed  Google Scholar 

  27. Labelle H, Roussouly P, Berthonnaud E, Transfeldt E, O'Brien M, Chopin D, Hresko T, Dimnet J (2004) Spondylolisthesis, pelvic incidence, and spinopelvic balance: a correlation study. Spine (Phila Pa 1976) 29:2049–2054

    Article  Google Scholar 

  28. Labelle H, Roussouly P, Berthonnaud E, Dimnet J, O'Brien M (2005) The importance of spino-pelvic balance in L5-s1 developmental spondylolisthesis: a review of pertinent radiologic measurements. Spine (Phila Pa 1976) 30:S27–S34

    Article  Google Scholar 

  29. Lenke LG, Bridwell KH, Bullis D, Betz RR, Baldus C, Schoenecker PL (1992) Results of in situ fusion for isthmic spondylolisthesis. J Spinal Disord 5:433–442

    Article  PubMed  CAS  Google Scholar 

  30. Leone A, Cianfoni A, Cerase A, Magarelli N, Bonomo L (2011) Lumbar spondylolysis: a review. Skeletal Radiol 40:683–700

    Article  PubMed  Google Scholar 

  31. Lonstein JE (1999) Spondylolisthesis in children. Cause, natural history, and management. Spine (Phila Pa 1976) 24:2640–2648

    Article  CAS  Google Scholar 

  32. Lowe RW, Hayes TD, Kaye J, Bagg RJ, Luekens CA (1976) Standing roentgenograms in spondylolisthesis. Clin Orthop Relat Res: 80–84

  33. Maldague BE, Malghem JJ (1976) Unilateral arch hypertrophy with spinous process tilt: a sign of arch deficiency. Radiology 121:567–574

    PubMed  CAS  Google Scholar 

  34. Masci L, Pike J, Malara F, Phillips B, Bennell K, Brukner P (2006) Use of the one-legged hyperextension test and magnetic resonance imaging in the diagnosis of active spondylolysis. Br J Sports Med 40:940–946, discussion 946

    Article  PubMed  CAS  Google Scholar 

  35. Meyerding H (1932) Spondylolisthesis. Surg Gynecol Obstet 54:371–377

    Google Scholar 

  36. Micheli LJ, Wood R (1995) Back pain in young athletes. Significant differences from adults in causes and patterns. Arch Pediatr Adolesc Med 149:15–18

    Article  PubMed  CAS  Google Scholar 

  37. Moller H, Sundin A, Hedlund R (2000) Symptoms, signs, and functional disability in adult spondylolisthesis. Spine (Phila Pa 1976) 25:683–689, discussion 690

    Article  CAS  Google Scholar 

  38. Nigrovic P (2011) Back pain in children and adolescents: overview of causes. http://wwwuptodatecom. Accessed 16 Oct 2012

  39. Ogilvie JW, Sherman J (1987) Spondylolysis in Scheuermann's disease. Spine (Phila Pa 1976) 12:251–253

    Article  CAS  Google Scholar 

  40. Ota H (1967) Spondylolysis: familial occurrence and its genetic implications. Nihon Seikeigeka Gakkai Zasshi 41:931–941

    PubMed  CAS  Google Scholar 

  41. Papanicolaou N, Wilkinson RH, Emans JB, Treves S, Micheli LJ (1985) Bone scintigraphy and radiography in young athletes with low back pain. AJR Am J Roentgenol 145:1039–1044

    PubMed  CAS  Google Scholar 

  42. Payne WK 3rd, Ogilvie JW (1996) Back pain in children and adolescents. Pediatr Clin N Am 43:899–917

    Article  Google Scholar 

  43. Phalen GS, Dickson JA (1961) Spondylolisthesis and tight hamstrings. J Bone Joint Surg 43:505–512

    Google Scholar 

  44. Pizzutillo PD, Mirenda W, MacEwen GD (1986) Posterolateral fusion for spondylolisthesis in adolescence. J Pediatr Orthop 6:311–316

    Article  PubMed  CAS  Google Scholar 

  45. Pizzutillo PD, Hummer CD 3rd (1989) Nonoperative treatment for painful adolescent spondylolysis or spondylolisthesis. J Pediatr Orthop 9:538–540

    Article  PubMed  CAS  Google Scholar 

  46. Raby N, Mathews S (1993) Symptomatic spondylolysis: correlation of CT and SPECT with clinical outcome. Clin Radiol 48:97–99

    Article  PubMed  CAS  Google Scholar 

  47. Rauch RA, Jinkins JR (1993) Lumbosacral spondylolisthesis associated with spondylolysis. Neuroradiol Clin North Am 3:543–553

    Google Scholar 

  48. Ravichandran G (1980) A radiologic sign in spondylolisthesis. AJR Am J Roentgenol 134:113–117

    PubMed  CAS  Google Scholar 

  49. Roche MB, Rowe GG (1952) The incidence of separate neural arch and coincident bone variations; a summary. J Bone Joint Surg 34-A:491–494

    PubMed  CAS  Google Scholar 

  50. Rossi F (1978) Spondylolysis, spondylolisthesis and sports. J Sports Med Phys Fitness 18:317–340

    PubMed  CAS  Google Scholar 

  51. Sairyo K, Katoh S, Takata Y, Terai T, Yasui N, Goel VK, Masuda A, Vadapalli S, Biyani A, Ebraheim N (2006) MRI signal changes of the pedicle as an indicator for early diagnosis of spondylolysis in children and adolescents: a clinical and biomechanical study. Spine 31:206–211

    Article  PubMed  Google Scholar 

  52. Saraste H (1987) Long-term clinical and radiological follow-up of spondylolysis and spondylolisthesis. J Pediatr Orthop 7:631–638

    PubMed  CAS  Google Scholar 

  53. Seitsalo S, Osterman K, Poussa M (1988) Scoliosis associated with lumbar spondylolisthesis. A clinical survey of 190 young patients. Spine (Phila Pa 1976) 13:899–904

    Article  CAS  Google Scholar 

  54. Seitsalo S, Osterman K, Poussa M, Laurent LE (1988) Spondylolisthesis in children under 12 years of age: long-term results of 56 patients treated conservatively or operatively. J Pediatr Orthop 8:516–521

    Article  PubMed  CAS  Google Scholar 

  55. Seitsalo S, Osterman K, Hyvarinen H, Tallroth K, Schlenzka D, Poussa M (1991) Progression of spondylolisthesis in children and adolescents. A long-term follow-up of 272 patients. Spine (Phila Pa 1976) 16:417–421

    Article  CAS  Google Scholar 

  56. Sherman FC, Rosenthal RK, Hall JE (1979) Spine fusion for spondylolysis and spondylolisthesis in children. Spine (Phila Pa 1976) 4:59–66

    Article  CAS  Google Scholar 

  57. Simper LB (1986) Spondylolysis in Eskimo skeletons. Acta Orthop Scand 57:78–80

    Article  PubMed  CAS  Google Scholar 

  58. Smith JA, Hu SS (1999) Management of spondylolysis and spondylolisthesis in the pediatric and adolescent population. Orthop Clin N Am 30:487–499, ix

    Article  CAS  Google Scholar 

  59. Speck GR, McCall IW, O'Brien JP (1984) Spondylolisthesis: the angle of kyphosis. Spine (Phila Pa 1976) 9:659–660

    Article  CAS  Google Scholar 

  60. Steiner ME, Micheli LJ (1985) Treatment of symptomatic spondylolysis and spondylolisthesis with the modified Boston brace. Spine (Phila Pa 1976) 10:937–943

    Article  CAS  Google Scholar 

  61. Stewart TD (1953) The age incidence of neural-arch defects in Alaskan natives, considered from the standpoint of etiology. J Bone Joint Surg 35-A:937–950

    PubMed  CAS  Google Scholar 

  62. Sys J, Michielsen J, Bracke P, Martens M, Verstreken J (2001) Nonoperative treatment of active spondylolysis in elite athletes with normal X-ray findings: literature review and results of conservative treatment. Eur Spine J 10:498–504

    Article  PubMed  CAS  Google Scholar 

  63. Szypryt EP, Twining P, Mulholland RC, Worthington BS (1989) The prevalence of disc degeneration associated with neural arch defects of the lumbar spine assessed by magnetic resonance imaging. Spine (Phila Pa 1976) 14:977–981

    Article  CAS  Google Scholar 

  64. Taillard WF (1955) Les spondylolisthesis chez l’enfant et l’adolescent (Etude de 50 cas). Acta Orthop Scand 24:115–144

    Google Scholar 

  65. Terai T, Sairyo K, Goel VK, Ebraheim N, Biyani A, Faizan A, Sakai T, Yasui N (2010) Spondylolysis originates in the ventral aspect of the pars interarticularis: a clinical and biomechanical study. J Bone Joint Surg Br 92:1123–1127

    Article  PubMed  CAS  Google Scholar 

  66. Tsirikos AI, Garrido EG (2010) Spondylolysis and spondylolisthesis in children and adolescents. J Bone Joint Surg Br 92:751–759

    Article  PubMed  CAS  Google Scholar 

  67. Turner RH, Bianco AJ Jr (1971) Spondylolysis and spondylolisthesis in children and teen-agers. J Bone Joint Surg 53:1298–1306

    PubMed  CAS  Google Scholar 

  68. van den Oever M, Merrick MV, Scott JH (1987) Bone scintigraphy in symptomatic spondylolysis. J Bone Joint Surg Br 69:453–456

    PubMed  Google Scholar 

  69. Ward CV, Latimer B, Alander DH, Parker J, Ronan JA, Holden AD, Sanders C (2007) Radiographic assessment of lumbar facet distance spacing and spondylolysis. Spine (Phila Pa 1976) 32:E85–E88

    Article  Google Scholar 

  70. Wiltse LL (1957) Etiology of spondylolisthesis. Clin Orthop 10:48–60

    PubMed  CAS  Google Scholar 

  71. Wiltse LL, Widell EH Jr, Jackson DW (1975) Fatigue fracture: the basic lesion is inthmic spondylolisthesis. J Bone Joint Surg 57:17–22

    PubMed  CAS  Google Scholar 

  72. Wiltse LL, Jackson DW (1976) Treatment of spondylolisthesis and spondylolysis in children. Clin Orthop Relat Res: 92–100

  73. Wiltse LL, Winter RB (1983) Terminology and measurement of spondylolisthesis. J Bone Joint Surg 65:768–772

    PubMed  CAS  Google Scholar 

  74. Wiltse LL, Guyer RD, Spencer CW, Glenn WV, Porter IS (1984) Alar transverse process impingement of the L5 spinal nerve: the far-out syndrome. Spine (Phila Pa 1976) 9:31–41

    Article  CAS  Google Scholar 

  75. Wynne-Davies R, Scott JH (1979) Inheritance and spondylolisthesis: a radiographic family survey. J Bone Joint Surg Br 61-B:301–305

    PubMed  CAS  Google Scholar 

  76. Yamane T, Yoshida T, Mimatsu K (1993) Early diagnosis of lumbar spondylolysis by MRI. J Bone Joint Surg Br 75:764–768

    PubMed  CAS  Google Scholar 

  77. Zehnder SW, Ward CV, Crow AJ, Alander D, Latimer B (2009) Radiographic assessment of lumbar facet distance spacing and pediatric spondylolysis. Spine (Phila Pa 1976) 34:285–290

    Article  Google Scholar 

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Correspondence to R. Shane Tubbs.

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Foreman, P., Griessenauer, C.J., Watanabe, K. et al. L5 spondylolysis/spondylolisthesis: a comprehensive review with an anatomic focus. Childs Nerv Syst 29, 209–216 (2013). https://doi.org/10.1007/s00381-012-1942-2

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  • DOI: https://doi.org/10.1007/s00381-012-1942-2

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