Abstract
In a mixture experiment, the response depends on the proportions of the mixing components. Canonical models of different degrees and also other models have been suggested to represent the mean response. Optimum designs for estimation of the parameters of the models have been investigated by different authors. In most cases, the optimum design includes the vertex points of the simplex as support points of the design, which are not mixture combinations in the true non-trivial sense. In this paper, optimum designs have been obtained when the experimental region is an ellipsoidal subspace of the entire factor space which does not cover the vertex points of the simplex.
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References
Atwood CL (1969) Optimal and efficient designs of experiments. Ann Math Stat 40:1570–1602
Batra PK, Parsad R, Gupta VK, Khanduri OP (1999) A strategy for analysis of experiments involving split application of fertilizer. Stat Appl 1:175–187
Cafaggi S, Leardi R, Parodi B, Caviglioli G, Bignardi G (2003) An example of application of a mixture design with constraints to a pharmaceutical formulation. Chemom Intell Lab Syst 65(1):139–147
Cornell J (2002), Experiments with mixtures: designs, models and the analysis of mixture data, 3rd ed. Wiley, New York
Deka BC, Sethi V, Parsad R, Batra PK (2001) Application of mixtures methodology for beverages from mixed fruit juice/pulp. J Food Sci Technol 38(6):615–618
Deneer JW (2000) Toxicity of mixtures of pesticides in aquatic systems. Pest Manag Sci 56:516–520
Dhekale JS, Parsad R, Gupta VK (2003) Analysis of intercropping experiments using experiments with mixtures methodology. J Indian Soc Agricul Stat 56(3):260–266
Draper NR, Pukelsheim F (1996) An overview of design of experiments. Stat Pap 37:1–32
Draper NR, Pukelsheim F (1999) Kiefer ordering of simplex designs for first and second degree mixture models. J Stat Plan Inf 79:325–348
Draper NR, Heiligers B, Pukelsheim F (2000) Kiefer ordering of simplex designs for second-degree mixture models with four or more ingredients. Ann Stat 28:578–590
Elfving G (1959) Design of linear experiments. In: Grenander U (ed) Probability and statistics. The Herald Cramer volume. Almquist and Wiksell, Stockholm, pp 58–74
Farrel RH, Kiefer JC, Walbran A (1967) Optimum multivariate design. In: Le-Cam LM, Neyman J (eds) Proceedings fifth Berkeley symposium on mathematical statistics and probability, Berkeley, CA, 1965 & 1966, vol 1, pp 113–138
Fedorov VV (1971) Design of experiments for linear optimality criteria. Theor Prob Appl 16:189–195
Galil Z, Kiefer J (1977) Comparison of simplex designs for quadratic mixture models. Technometrics 19:445–453
Karlin S, Studden WJ (1966) Optimal experimental designs. Ann Math Stat 37:783–815
Kiefer J (1961) Optimum designs in regression problems II. Ann Math Stat 32:298–325
Kiefer J, Wolfowitz j (1959) Optimum designs in regression problems. Ann Math Stat 30:271–294
Li KH, Lau TS, Zhang C (2005) A note on D-optimal designs for models with and without an intercept. Stat Pap 46:451–458
Liski EP, Zaigraev A (2001) A stochastic characterization of Loewner optimality design criterion in linear models. Metrika 53:207–222
Liski EP, Luoma A, Mandal NK, Sinha BK (1998) Pitman nearness, distance criterion and optimal regression designs. Cal Stat Assoc Bull 48:179–194
Liu S, Neudecker H (1997) Experiments with mixtures: optimal allocation for Becker’s models. Metrika 45:53–66
Mandal NK, Pal M (2008) Optimum mixture design using deficiency criterion. Comm Stat Theory Methods 37(10):1565–1575
Mandal NK, Pal M, Sinha BK, Das P (2008a) Optimum mixture designs: a pseudo-Bayesian approach. J Ind Soc Agril Stat 62(2):174–182
Mandal NK, Pal M, Sinha BK, Das P (2008b) Optimum mixture designs under constraints on mixing components. Stat Appl 6(1 & 2) (New Series), 189–205
Osborne TB, Mendel LB (1921) Feeding experiments with mixtures of foodstuffs in unusual proportions. Proc Natl Acad Sci 7:157–162
Pal M, Mandal NK (2006) Optimum designs for optimum mixtures. Stat Probab Lett 76:1369–1379
Pal M, Mandal NK (2007) Optimum mixture design via equivalence theorem. J Comb Inf Syst Sci 32(2):107–126
Pal M, Mandal NK (2008) Minimax designs for optimum mixtures. Stat Probab Lett 78(6):608–615
Pal M, Mandal NK (2009) Optimum designs for estimation of optimum point under cost constraint. J Appl Stat 36(9):999–1008
Pukelsheim F (1993) Optimal design of experiments. Wiley, New York
Scheffé H (1958) Experiments with mixtures. J R Stat Soc B 20:344–360
Scheffé H (1963) Simplex—centroid design for experiments with mixtures. J R Stat Soc B 25:235–263
Snee RD (1981) Developing blending models for gasoline and other mixtures. Technometrics 23:119–130
Acknowledgments
The authors thank the anonymous referees for their fruitful suggestions, which immensely helped to improve the presentation of the paper. The authors also acknowledge with thanks the support received from their UPE project under Calcutta University.
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Mandal, N.K., Pal, M., Sinha, B.K. et al. Optimum mixture designs in a restricted region. Stat Papers 56, 105–119 (2015). https://doi.org/10.1007/s00362-013-0568-0
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DOI: https://doi.org/10.1007/s00362-013-0568-0