Zusammenfassung
Die Neuritis nervi optici ist eine der wichtigsten Differenzialdiagnosen der akuten Sehverschlechterung im jungen und mittleren Erwachsenenalter. Die Diagnose wird klinisch gestellt. Die funktionelle Prognose der Erkrankung ist grundsätzlich gut. Steroide verkürzen das Erholungsintervall, ändern jedoch nichts an der funktionellen Langzeitprognose. Wichtigste Untersuchung zur Abschätzung eines möglichen Multiple-Sklerose-Risikos ist die Magnetresonanztomographie. Die optische Kohärenztomographie liefert zusätzliche Hinweise auf Verlauf und Funktion nach Neuritis nervi optici und kann in Zukunft vielleicht weitere Zusammenhänge zwischen Neuritis nervi optici und evtl. multipler Sklerose liefern.
Abstract
Optic nerve neuritis is one of the most important differential diagnoses of visual loss in young and middle aged adults. The prognosis in terms of functional outcome is generally good. The diagnosis of optic neuritis is clinical. Steroids can reduce the recovery time but do not affect the long-term functional outcome. Magnetic resonance imaging (MRI) is the most important investigation for assessing an associated risk of multiple sclerosis. Optical coherence tomography (OCT) contributes additional details on the course and functional outcome of optic neuritis. In the future OCT may additionally contribute to the relationship between optic neuritis and possible associated multiple sclerosis.
Abbreviations
- MRT:
-
Magnetresonanztomographie
- MS:
-
multiple Sklerose
- NNO:
-
Neuritis nervi optici
- OCT:
-
optische Kohärenztomographie
- VEP:
-
visuell evozierte Potenziale
Literatur
Beck RW (1992) The optic neuritis treatment trial. Implications for clinical practice. Optic Neuritis Study Group. Arch Ophthalmol 110(3):331–332
Beck RW, Gal RL (2008) Treatment of acute optic neuritis: a summary of findings from the optic neuritis treatment trial. Arch Ophthalmol 126(7):994–995
Volpe NJ (2008) The optic neuritis treatment trial: a definitive answer and profound impact with unexpected results. Arch Ophthalmol 126(7):996–999
Roed HG et al (2005) A double-blind, randomized trial of iv immunoglobulin treatment in acute optic neuritis. Neurology 64(5):804–810
Tselis A et al (2008) Treatment of corticosteroid refractory optic neuritis in multiple sclerosis patients with intravenous immunoglobulin. Eur J Neurol 15(11):1163–1167
Comi G et al (2001) Effect of early interferon treatment on conversion to definite multiple sclerosis: a randomised study. Lancet 357(9268):1576–1582
Comi G et al (2009) Effect of glatiramer acetate on conversion to clinically definite multiple sclerosis in patients with clinically isolated syndrome (PreCISe study): a randomised, double-blind, placebo-controlled trial. Lancet 374(9700):1503–1511
Kappos L et al (2009) Long-term effect of early treatment with interferon beta-1b after a first clinical event suggestive of multiple sclerosis: 5-year active treatment extension of the phase 3 BENEFIT trial. Lancet Neurol 8(11):987–997
Jacobs LD et al (2000) Intramuscular interferon beta-1a therapy initiated during a first demyelinating event in multiple sclerosis. CHAMPS Study Group. N Engl J Med 343(13):898–904
Kinkel RP et al (2006) IM interferon beta-1a delays definite multiple sclerosis 5 years after a first demyelinating event. Neurology 66(5):678–684
Wingerchuk DM et al (2007) The spectrum of neuromyelitis optica. Lancet Neurol 6(9):805–815
Ratchford JN et al (2009) Optical coherence tomography helps differentiate neuromyelitis optica and MS optic neuropathies. Neurology 73(4):302–308
Costello F et al (2006) Quantifying axonal loss after optic neuritis with optical coherence tomography. Ann Neurol 59(6):963–969
Beck RW et al (2003) High- and low-risk profiles for the development of multiple sclerosis within 10 years after optic neuritis: experience of the optic neuritis treatment trial. Arch Ophthalmol 121(7):944–949
Henderson AP et al (2010) A preliminary longitudinal study of the retinal nerve fiber layer in progressive multiple sclerosis. J Neurol 257(7):1083–1091
Petzold A et al (2010) Optical coherence tomography in multiple sclerosis: a systematic review and meta-analysis. Lancet Neurol 9(9):921–932
Naismith RT et al (2009) Optical coherence tomography is less sensitive than visual evoked potentials in optic neuritis. Neurology 73(1):46–52
Interessenkonflikt
H. Steffen gibt an, dass kein Interessenkonflikt besteht. Dieser Beitrag beinhaltet keine Studien an Menschen oder Tieren.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Steffen, H. Neuritis nervi optici. Ophthalmologe 110, 783–794 (2013). https://doi.org/10.1007/s00347-013-2906-y
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00347-013-2906-y