Skip to main content
SpringerLink
Log in

Analysis of serum from type II diabetes mellitus and diabetic complication using surface-enhanced Raman spectra (SERS)

  • Published:
Applied Physics B Aims and scope Submit manuscript

Abstract

In this paper, we show surface-enhanced Raman spectra (SERS) of serums from type II diabetes mellitus and diabetic complication (coronary disease, glaucoma and cerebral infarction), and analyze the SERS through the multivariate statistical methods of principal component analysis (PCA). In particular, we find that there exist many adenines in these serums, which maybe come from DNA (RNA) damage. The relative intensity of the band at 725±2 cm−1 assigned to adenine is higher for patients than for the healthy volunteers; therefore, it can be used as an important ‘fingerprint’ in order to diagnose these diseases. It is also shown that serums from type II diabetes mellitus group, diabetic complication group and healthy volunteers group can be discriminated by PCA.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. D. Rohleder, W. Kiefer, W. Petrich, Analyst 129, 906 (2004)

    Article  ADS  Google Scholar 

  2. S. Kreisig, A. Tarazona, E. Koglin, Electrochim. Acta 42, 3335 (1997)

    Article  Google Scholar 

  3. A. Otto, I. Mrozek, H. Grabhom, W. Akemann, J. Phys. Condens. Matter 4, 1143 (1992)

    Article  ADS  Google Scholar 

  4. H.X. Xu, E.J. Bjerneld, M. Kall, L. Borjesson, Phys. Rev. Lett. 83, 4357 (1999)

    Article  ADS  Google Scholar 

  5. K. Kneipp, A.S. Haka, H. Kneipp, K. Badizadegan, N. Yoshizawa, C. Boone, K.E. Shafer-Peltier, J.T. Motz, R.R. Dasari, M.S. Feld, Appl. Spectrosc. 56, 150 (2002)

    Article  ADS  Google Scholar 

  6. K. Kneipp, Y. Wang, R.R. Dasari, M.S. Feld, Appl. Spectrosc. 49, 780 (1995)

    Article  ADS  Google Scholar 

  7. C. Eliasson, A. Lorén, J. Engelbrektsson, M. Josefson, J. Abrahamsson, K. Abrahamsson, Spectrochim. Acta Part A 61, 755 (2005)

    Article  Google Scholar 

  8. K. Kneipp, A.S. Haka, H. Kneipp, K. Badizadegan, N. Yoshizawa, C. Boone, K.E. Shafer-Peltier, J.T. Motz, R.R. Dasari, M.S. Feld, Appl. Spectrosc. 56, 150 (2002)

    Article  ADS  Google Scholar 

  9. G. Fabriciova, S. Sanchez-Cortes, J.V. Garcia-Ramos, P. Miskovsky, Biopolymers 74, 125 (2004)

    Article  Google Scholar 

  10. P. Miskovsky, J. Hritz, S. Sanchez-Cortes, Photochem. Photobiol. 74, 172 (2001)

    Article  Google Scholar 

  11. J.L. Pichardo-Molina, C. Frausto-Reyes, O. Barbosa-Garcia, R. Huerta-Franco, J.L. Gonzales-Trujillo, C.A. Ramirez-Alvarado, G. Gutierrez-Juarez, C. Medina-Gutierrez, Lasers Med. Sci. 22, 229 (2007)

    Article  Google Scholar 

  12. A.M.K. Enejder, T.-W. Koo, J. Oh, M. Hunter, S. Sasic, M.S. Feld, G.L. Horowitz, Opt. Lett. 27, 2004 (2002)

    Article  ADS  Google Scholar 

  13. A.J. Berger, T.-W. Koo, I. Itzkan, G. Horowitz, M.S. Feld, Appl. Opt. 38, 2916 (1999)

    Article  Google Scholar 

  14. C.R. Lee, S.J. Bae, M.S. Gong, K. Kim, S.W. Joo, J. Raman Spectrosc. 33, 429 (2002)

    Article  Google Scholar 

  15. A. Callegari, D. Tonti, M. Chergui, Nano Lett. 11, 1565 (2003)

    Article  Google Scholar 

  16. Z.Y. Zhang, Y.M. Xu, Sci. Chin. Ser. B 12, 595 (1991)

    Google Scholar 

  17. L. Dostal, R. Misselwitz, S. Laettig, J.C. Alonso, H. Welfle, Spectroscopy 17, 435 (2003)

    Google Scholar 

  18. D.C. Goodwin, J. Brahms, Nucleic Acids Res. 5, 835 (1978)

    Article  Google Scholar 

  19. R.C. Lord, N.T. Yu, J. Mol. Biol. 50, 509 (1970)

    Article  Google Scholar 

  20. Z.Y. Zhang, Y.M. Xu, Sci. China Ser. B 35, 437 (1992)

    Google Scholar 

  21. B.P. Gaber, W.L. Peticolas, Biochem. Biophys. Acta 465, 260 (1997)

    Google Scholar 

  22. Y.M. Xu, C.Z. Lu, Sci. China Ser. C (Life Sci.) 48, 117 (1997)

    Google Scholar 

  23. C.Y. She, N.D. Dinh, A.T. Tu, Biochim. Biophys. Acta 372, 345 (1974)

    Google Scholar 

  24. H.X. Zhao, Y.M. Xu, C.Z. Lu, Asian J. Spectrosc. 1, 71 (1997)

    Google Scholar 

  25. S. Raychaudhuri, J.M. Stuart, R.B. Altman, Pac. Symp. Biocomput. 5, 452 (2000)

    Google Scholar 

  26. M.A. Kramer, AIChE J. 37, 233 (1991)

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. School of Physical Science and Information Technology, Liaocheng University, Shandong, Liaocheng, 252059, China

    H. W. Han, X. L. Yan, R. X. Dong, G. Ban & K. Li

Authors
  1. H. W. Han
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. X. L. Yan
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. R. X. Dong
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. G. Ban
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. K. Li
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to X. L. Yan.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Han, H.W., Yan, X.L., Dong, R.X. et al. Analysis of serum from type II diabetes mellitus and diabetic complication using surface-enhanced Raman spectra (SERS). Appl. Phys. B 94, 667–672 (2009). https://doi.org/10.1007/s00340-008-3299-5

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00340-008-3299-5

PACS

Search

Navigation