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Mutation watch: Mouse brachyury (T), the T-box gene family, and human disease

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References

  • Agulnik SI, Bollag RJ, Silver LM (1995) Conservation of the T-box gene from Mus musculus to Caenorhabditis elegans. Genomics 25, 214–219

    Article  PubMed  CAS  Google Scholar 

  • Bamshad M, Lin RC, Law DJ, Watkins WS, Krakowiak PA, Moore ME, Franceschini P, Lala R, Holmes LB, Gebuhr TC, Bruneau BG, Scidman JG, Scidman CE, Jorde LB (1997) Mutations in human TBX3 alter limb, apocrine and genital development in ulnar-mammary syndrome. Nature Genet, in press

  • Basson CT, Bachinsky DR, Lin RC, Levi T, Elkins JA, Soults J, Grayzel D, Kroumpouzou E, Traill TA, Leblanc-Straceski J, Renault B, Kucherlapati R, Seidman JG, Scidman CE (1997) Mutations in human TBX5 cause limb and cardiac malformation in Holt-Oram syndrome. Nature Genet 15, 30–35

    Article  PubMed  CAS  Google Scholar 

  • Bollag RJ, Siegfried Z, Cebra-Thomas JA, Garvey N, Davison EM, Silver LM (1994) An ancient family of embryonically expressed mouse genes sharing a conserved protein motif with the T locus. Nature Genet 7, 383–389

    Article  PubMed  CAS  Google Scholar 

  • Bulfone A, Smiga SM, Shimamura K, Peterson A, Puelles L, Rubenstein JL (1995) T-brain-1: a homolog of brachyury whose expression defines molecularly distinct domains within the cerebral cortex. Neuron 15, 63–78

    Article  PubMed  CAS  Google Scholar 

  • Edwards YH, Putt W, Lekoape KM, Stott D, Fox M, Hopkinson DA, Sowden J (1996) The human homolog T of the mouse T(brachyury) gene; gene structure, cDNA sequence, and assignment to chromosome 6q27. Genome Res 6, 226–233

    Article  PubMed  CAS  Google Scholar 

  • Herrmann BG, Labeit S, Poustka A, King TR, Lehrach H (1990) Cloning of the T gene required in mesoderm formation in the mouse. Nature 343, 617–622

    Article  PubMed  CAS  Google Scholar 

  • Kispert A, Koschorz B, Herrmann BG (1995) The T protein encoded by brachyury is a tissue-specific transcription factor. EMBO J 14, 4763–4772

    PubMed  CAS  Google Scholar 

  • Li QY, Newbury-Ecob RA, Terrett JA, Wilson DI, Curtis ARJ, Yi CH, Gebuhr T, Bullen PJ, Robson SC, Strachan T, Bonnet D, Lyonnet S, Young ID, Raeburn JA, Buckler AJ, Law DJ, Brook JD (1997) Holt-Oram Syndrome is caused by mutations in TBX5, a member of Brachyury (T) family. Nature Genet 15, 21–29

    Article  PubMed  Google Scholar 

  • Pflugfelder GO, Roth H, Poeck B (1992) A homology domain shared between Drosophila optomotor-blind and mouse brachyury is involved in DNA binding. Biochem Biophys Res Commun 186, 918–925

    Article  PubMed  CAS  Google Scholar 

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Meisler, M.H. Mutation watch: Mouse brachyury (T), the T-box gene family, and human disease. Mammalian Genome 8, 799–800 (1997). https://doi.org/10.1007/s003359900581

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