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Incidental focal FDG uptake in the parotid glands on PET/CT in patients with head and neck malignancy

  • Head and Neck
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Abstract

Objectives

To evaluate the prevalence and clinical significance of focal parotid lesions identified by 18 F- FDG PET/CT in patients with nonparotid head and neck malignancies.

Methods

From 3,638 PET/CT examinations using 18 F-FDG conducted on 1,342 patients with nonparotid head and neck malignancies, we retrospectively identified patients showing incidental focal FDG uptake in the parotid glands. The diagnosis of parotid lesions was confirmed histopathologically or on imaging follow-up. Patient demographics, clinical features, maximum standardized uptake value (SUVmax) on PET images, size and attenuation on corresponding contrast-enhanced CT images were assessed and correlated with the final diagnosis.

Results

The prevalence of incidental focal parotid FDG uptake on PET/CT was 2.1 % (95 % CI 1.4 – 3.0 %). Among 21 patients with focal parotid lesions confirmed histologically or on imaging follow-up, 7 (33.3 %) had malignant lesions (all metastases) and 14 (66.7 %) had benign lesions (four pleomorphic adenomas, two Warthin's tumours, one benign lymph node, one granulomatous lesion, six lesions without histopathological confirmation). There were no significant differences in age, sex, SUVmax or CT findings between patients with benign and those with malignant lesions.

Conclusion

Focal parotid FDG uptake on PET/CT in patients with head and neck malignancy warrants further investigations to ensure adequate therapy for incidental parotid lesions.

Key Points

• The prevalence of parotid incidentaloma on PET in head and neck malignancy was 2.1 %

• The malignancy rate of incidental focal parotid FDG uptake was 33.3 %

• SUV max could not reliably differentiate malignant from benign incidental parotid lesions

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Acknowledgments

The scientific guarantor of this publication is Dae Young Yoon. The authors declare no relationships with any companies whose products or services may have been related to the subject matter of the article. The authors state that this work did not receive any funding. No complex statistical methods were necessary for this study.

Institutional Review Board approval was obtained. Written informed consent was waived by the Institutional Review Board. Methodology: retrospective, observational, performed at one institution.

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Authors and Affiliations

  1. Department of Radiology, Kangdong Seong-Sim Hospital, Hallym University College of Medicine, 150, Seongan-ro Gangdong-Gu, Seoul, 134-701, Korea

    Young Lan Seo, Dae Young Yoon, Kyoung Ja Lim, Eun Joo Yun & Young Kwon Cho

  2. Department of Nuclear Medicine, Kangdong Seong-Sim Hospital, Hallym University College of Medicine, Seoul, Korea

    Sora Baek

  3. Department of Otorhinolaryngology, Ilsong Memorial Institute of Head and Neck Cancer, Kangdong Seong-Sim Hospital, Hallym University College of Medicine, Seoul, Korea

    Woo Jin Bae, Eun Jae Chung & Kee Hwan Kwon

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  1. Young Lan Seo
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  4. Kyoung Ja Lim
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  9. Kee Hwan Kwon
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Correspondence to Dae Young Yoon.

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Seo, Y.L., Yoon, D.Y., Baek, S. et al. Incidental focal FDG uptake in the parotid glands on PET/CT in patients with head and neck malignancy. Eur Radiol 25, 171–177 (2015). https://doi.org/10.1007/s00330-014-3397-1

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  • DOI: https://doi.org/10.1007/s00330-014-3397-1

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