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Use of medication reminders in patients with rheumatoid arthritis

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Abstract

Patients with rheumatoid arthritis (RA) often have difficulties adhering to their medical treatment plans. We determined the characteristics of patients with RA who used reminders and the association between reminders and adherence. A total of 201 patients with RA were asked the frequency of reminders use such as pill containers, calendars, or diaries. Patients completed self-reported adherence questionnaires, and their disease activity and functional ability were measured. Sixty-eight patients (34 %) reported using a reminder. Factors associated with reminder use were older age (yes-mean age 54 vs no-mean age 49, p = 0.004), race (Whites—54 % vs Blacks—30 % vs Hispanics—26 %, p = 0.003), and sex (males—50 % vs females 28 %, p = 0.005). Working patients were less likely to use reminders (employed—21 % vs unemployed—43 %, p = 0.006). Use of calendars was associated with adherence while away from home (ρ = 0.16, p = 0.03), when busy (ρ = 0.16, p = 0.03), and use of any reminder was associated with adherence when running out of pills (ρ = 0.15, p = 0.04). The use of calendar reminders was associated with fewer tender joints (ρ = −0.17, p = 0.02). Few patients with RA used reminders, and whites, males and patients of increasing age were most likely to use reminders. Our findings show that reminders can assist patients with RA in taking medications, particularly when they are most prone to forgetting, such as when they are away from home or busy. Providers should encourage using reminders as a low-cost aid to enhance adherence.

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References

  1. Kardas P, Lewek P, Matyjaszczyk M (2013) Determinants of patient adherence: a review of systematic reviews. Front Pharmacol 4(91). doi:10.3389/fphar.2013.00091

  2. Waimann CA, Marengo MF, de Achaval S, Cox VL, Garcia-Gonzalez A, Reveille JD, Richardson MN, Suarez-Almazor ME (2013) Electronic monitoring of oral therapies in ethnically diverse and economically disadvantaged patients with rheumatoid arthritis: consequences of low adherence. Arthritis Rheum 65(6):1421–1429. doi:10.1002/art.37917

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, Healey LA, Kaplan SR, Liang MH, Luthra HS (1988) The American rheumatism association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 31(3):315–324

    Article  CAS  PubMed  Google Scholar 

  4. Garcia-Gonzalez A, Richardson M, Garcia Popa-Lisseanu M, Cox V, Kallen MA, Janssen N, Ng B, Marcus DM, Reveille JD, Suarez-Almazor ME (2008) Treatment adherence in patients with rheumatoid arthritis and systemic lupus erythematosus. Clin Rheumatol 27(7):883–889. doi:10.1007/s10067-007-0816-6

    Article  PubMed  Google Scholar 

  5. de Klerk E, van der Heijde D, Landewé R, van der Tempel H, van der Linden S (2003) The compliance-questionnaire-rheumatology compared with electronic medication event monitoring: a validation study. J Rheumatol Supplement 30(11):2469–2475

    Google Scholar 

  6. Chesney MA, Ickovics JR, Chambers DB, Gifford AL, Neidig J, Zwickl B, Wu AW (2000) Self-reported adherence to antiretroviral medications among participants in HIV clinical trials: the AACTG adherence instruments. Patient care committee and adherence working group of the outcomes committee of the adult AIDS clinical trials group (AACTG). AIDS Care 12(3):255–266

    Article  CAS  PubMed  Google Scholar 

  7. Fries JF, Spitz P, Kraines RG, Holman HR (1980) Measurement of patient outcome in arthritis. Arthritis Rheum 23(2):137–145

    Article  CAS  PubMed  Google Scholar 

  8. Tuncay R, Eksioglu E, Cakir B, Gurcay E, Cakci A (2007) Factors affecting drug treatment compliance in patients with rheumatoid arthritis. Rheumatol Int 27(8):743–746. doi:10.1007/s00296-006-0299-9

    Article  PubMed  Google Scholar 

  9. Park DC, Hertzog C, Leventhal H, Morrell RW, Leventhal E, Birchmore D, Martin M, Bennett J (1999) Medication adherence in rheumatoid arthritis patients: older is wiser. J Am Geriatr Soc 47(2):172–183

    Article  CAS  PubMed  Google Scholar 

  10. Dunbar-Jacob J, Holmes JL, Sereika S, Kwoh CK, Burke LE, Starz TW, McCall M, Foley SM (2004) Factors associated with attrition of African Americans during the recruitment phase of a clinical trial examining adherence among individuals with rheumatoid arthritis. Arthritis Rheum 51(3):422–428. doi:10.1002/art.20411

    Article  PubMed  Google Scholar 

  11. Marengo MF, Waimann CA, de Achaval S, Zhang H, Garcia-Gonzalez A, Richardson MN, Reveille JD, Suarez-Almazor ME (2012) Measuring therapeutic adherence in systemic lupus erythematosus with electronic monitoring. Lupus 21(11):1158–1165. doi:10.1177/0961203312447868

    Article  CAS  PubMed  Google Scholar 

  12. Fenerty SD, West C, Davis SA, Kaplan SG, Feldman SR (2012) The effect of reminder systems on patients’ adherence to treatment. Patient Prefer Adher 6:127–135. doi:10.2147/ppa.s26314

    Google Scholar 

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Acknowledgments

We are grateful to Maria E. Suarez-Almazor, MD, PhD, from The University of Texas MD Anderson Cancer Center Department of General Internal Medicine for providing the data for analysis in this study.

Author contributions

Dr. Lopez-Olivo had full access to all of the data in the study and takes responsibility for the integrity and the accuracy of the data analysis. Lopez-Olivo contributed to study concept and design, and supervision of the study.; Suarez-Almazor acquired data; Bruera, Barbo, and Lopez-Olivo analyzed and interpreted the data, and drafted and critically revised the manuscript; Statistical analysis was performed by Barbo; Suarez-Almazor obtained funding and provided administrative, technical, or material support.

Funding

The data for this analysis are part of a study supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS R01AR047858). Dr. Lopez-Olivo is the recipient of an investigator career award from the Rheumatology Research Foundation.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Correspondence to Maria A. Lopez-Olivo.

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S. Bruera declares that he has no conflict of interest. A. Barbo declares that she has no conflict of interest. M.A. Lopez-Olivo declares that she has no conflict of interest.

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Bruera, S., Barbo, A.G. & Lopez-Olivo, M.A. Use of medication reminders in patients with rheumatoid arthritis. Rheumatol Int 36, 1543–1548 (2016). https://doi.org/10.1007/s00296-016-3558-4

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