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Associations between the major histocompatibility complex class I chain-related gene A transmembrane (MICA-TM) polymorphism and susceptibility to psoriasis and psoriatic arthritis: a meta-analysis

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Abstract

The aim of this study was to assess whether the major histocompatibility complex class I chain-related gene A transmembrane (MICA-TM) polymorphism is associated with the susceptibility to psoriasis and psoriatic arthritis (PsA). A meta-analysis was conducted to establish the association between the MICA-TM A9 allele and psoriasis and PsA in the general population and each ethnic group. Ten studies (6 psoriasis, 4 PsA) involving 2,002 cases and 1,933 controls were included in this meta-analysis. The Asian controls showed the lowest A9 allele prevalence (16.6 %), whereas the European controls had the highest allele prevalence (33.3 %). Meta-analysis revealed a significant association between the MICA-TM A9 allele and the entire study population, which included the psoriasis and PsA cases (OR 1.703; 95 % CI 1.301–2.229; p = 1.0 × 10−5). We further divided the entire study population into the psoriasis and PsA groups. Meta-analysis revealed a significant association between the MICA-TM A9 allele and the entire study population (OR 1.427, 95 % CI 1.021–1.994; p = 0.037) and Asians (OR 1.264; 95 % CI 1.014–1.576; p = 0.037). A significant association was found between the MICA-TM A9 allele and PsA (OR 2.227; 95 % CI 1.462–3.393; p = 1.9 × 10−5) and Europeans (OR 2.039; 95 % CI 1.285–3.235; p = 0.002). This meta-analysis showed that the MICA-TM A9 allele is associated with psoriasis susceptibility in Asian populations and that the MICA-TM A9 allele is associated with a PsA risk in Europeans.

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This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.

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  1. Division of Rheumatology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, 126-1, Anam-dong 5-ga, Seongbuk-gu, Seoul, 136-705, Korea

    Gwan Gyu Song, Jae-Hoon Kim & Young Ho Lee

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  1. Gwan Gyu Song
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  2. Jae-Hoon Kim
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Correspondence to Young Ho Lee.

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Song, G.G., Kim, JH. & Lee, Y.H. Associations between the major histocompatibility complex class I chain-related gene A transmembrane (MICA-TM) polymorphism and susceptibility to psoriasis and psoriatic arthritis: a meta-analysis. Rheumatol Int 34, 117–123 (2014). https://doi.org/10.1007/s00296-013-2849-2

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  • DOI: https://doi.org/10.1007/s00296-013-2849-2

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