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Detritussynovialitis und seltene Skeletterkrankungen

Detritic synovitis and rare skeletal diseases

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Zusammenfassung

Die Detritussynovialitis repräsentiert einen häufigen Befund in der orthopädischen Pathologie. Die mikroskopischen Kennzeichen sind intrasynoviale Knorpel- und Knochenfragmente, Kalzifikationen und eine mesenchymale resorptive Reaktion. Die Detritussynovialitis ist meistens mit gelenkdestruktiven Prozessen wie Arthrose, Arthritiden, avaskulären Nekrosen, Diabetes mellitus, Charcot-Arthropathie oder gelenknahen Knochenbrüchen assoziiert, die mikroskopischen Befunde in der Synovialmembran sind für diese Skeletterkrankungen jedoch unspezifisch. Ein kleiner Teil gut definierter seltener Skeletterkrankungen (Ochronose, rasch destruierende Hüfterkrankung und Kalzinose) kann von der unspezifischen Detritussynovialitis abgegrenzt werden. In diesem Beitrag werden mikroskopische Befunde bei der Detritussynovialitis und seltenen Skeletterkrankungen diskutiert.

Abstract

Detritic synovitis represents a common finding in routine orthopedic pathology. Microscopically, the synovium displays cartilaginous and bony fragments in the synoviocyte layer or within the subsynovial soft tissues associated with resorptive changes. In the vast majority of cases, detritic synovitis is associated with conditions leading to the destruction of articular cartilage and subchondral bone, such as severe osteoarthritis, collapsed avascular necrosis, diabetes mellitus, Charcot arthropathy or non-union fractures. The objective of this article is to review the literature regarding the microscopic findings in ochronosis, rapidly destructive hip disease and apatite crystal depositions that can enable a confident diagnosis or a limited differential diagnosis of detritic synovitis.

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Einhaltung ethischer Richtlinien

Interessenkonflikt. J. Zustin gibt an, dass kein Interessenkonflikt besteht. Dieser Beitrag beinhaltet keine Studien an Menschen oder Tieren.

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  1. Gerhard Domagk Institut für Pathologie, Universitätsklinikum Münster, Domagkstr. 17, 48149, Münster, Deutschland

    J. Zustin

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The supplement this article is part of is not sponsored by the industry.

Ein Teil dieser Arbeit wurde bei der 98. Jahrestagung der Deutschen Gesellschaft für Pathologie e. V. präsentiert.

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Zustin, J. Detritussynovialitis und seltene Skeletterkrankungen. Pathologe 35 (Suppl 2), 214–217 (2014). https://doi.org/10.1007/s00292-014-1977-0

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  • DOI: https://doi.org/10.1007/s00292-014-1977-0

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