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Tropheryma-whipplei-Endokarditis

Tropheryma whipplei endocarditis

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Zusammenfassung

Der Morbus Whipple ist eine seltene Infektionskrankheit, verursacht durch das Bakterium Tropheryma whipplei. Meistens verläuft die Erkrankung mit klassischen Symptomen wie Fieber, Gewichtsverlust, Diarrhö und Polyarthritis. Wir berichten über einen 10 Jahre dauernden Krankheitsverlauf mit Endokarditis, Myokarditis und Knochenmarkbefall bei negativer Dünndarmhistologie.

Abstract

Whipple’s disease is a rare infectious disease caused by the bacterium Tropheryma whipplei. Usually the course of the disease is characterized by fever, diarrhea, weight loss and polyarthritis. We report on a case with a 10-year course of the disease with endocarditis, myocarditis and involvement of the bone marrow but with negative histological results of the small intestine.

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Literatur

  1. Dutly F, Altwegg M (2001) Whipple’s disease and ‚‚Tropheryma whippelii’’. Clin Microbiol Rev 14:561–583

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  2. Fenollar F, Raoult D (2001) Whipple’s disease. Clin Diagn Lab Immunol 8:1–8

    CAS  PubMed Central  PubMed  Google Scholar 

  3. Geissdörfer W, Moos V, Moter A et al (2012) High frequency of Tropheryma whipplei in culture-negative endocarditis. J Clin Microbiol 50(2):216–222

    Article  PubMed Central  PubMed  Google Scholar 

  4. Gunia S, Behrens MH, Stosiek P (2004) A rare course of Whipple’s disease with atypical cardiac manifestation. APMIS 112(3):222–224

    Article  CAS  PubMed  Google Scholar 

  5. Lagier JC, Lepidi H, Raoult D, Fenollar F (2010) Systemic Tropheryma whipplei: clinical presentation of 142 patients with infections diagnosed or confirmed in a reference center. Medicine (Baltimore) 89(5):337–345

    Google Scholar 

  6. Maiwald M (2009) Tropheryma whipplei. In: Neumeister B, Geiss HK, Braun RW, Kimmig K (Hrsg) Mikrobiologische Diagnostik. Thieme, Stuttgart, S 380–386

  7. Marth T, Raoult D (2003) Whipple’s disease. Lancet 361:239–246

    Article  PubMed  Google Scholar 

  8. Relman DA, Schmidt TM, MacDermott RP, Falcow S (1992) Identification of the uncultured bacillus of Whipple’s disease. N Engl J Med 327(5):293–301

    Article  CAS  PubMed  Google Scholar 

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Correspondence to M. Fritz M.D..

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Fritz, M., Schlinke, H. & Fayyazi, A. Tropheryma-whipplei-Endokarditis. Pathologe 35, 274–276 (2014). https://doi.org/10.1007/s00292-013-1791-0

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  • DOI: https://doi.org/10.1007/s00292-013-1791-0

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